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Article: Frontal and temporal sources of mismatch negativity in healthy controls, patients at onset of schizophrenia in adolescence and others at 15 years after onset

TitleFrontal and temporal sources of mismatch negativity in healthy controls, patients at onset of schizophrenia in adolescence and others at 15 years after onset
Authors
KeywordsAttention
Cingulate
Dipole
Frontal cortex
Mismatch Negativity (MMN)
Schizophrenia
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2005, v. 76 n. 1, p. 25-41 How to Cite?
AbstractMismatch negativity (MMN) is an event-related potential measure of auditory change detection. It is widely reported to be smaller in patients with schizophrenia and may not improve along with otherwise successful clinical treatment. The main aim of this report is to explore ways of measuring and presenting four features of frequency-deviant MMN dipole sources (dipole moment, peak latency, brain location and orientation) and to relate these to the processes of psychopathology and illness progression. Data from early onset patients (EOS) at the start of the illness in adolescence, and others who had their first break in adolescence 15 years ago (S-15Y) were compared with two groups of age-matched healthy controls (C-EOS, C-15Y). A four-source model fitted the MMN waveform recorded from all four groups, whether MMN amplitude was more (EOS) or less (S-15Y) reduced. The locations were in the left superior temporal and anterior cingulate gyri, right superior temporal and inferior/mid frontal cortices. Dipole latencies confirmed a bottom-up sequence of processing and dipole moments were larger in the temporal lobes and on the left. Patients showed small dipole location changes that were more marked in the S-15Y than the EOS group (more rostral for the left anterior cingulate, more caudal for the right mid-frontal dipole) consistent with illness progression. The modelling of MMN dipole sources on brain atlas and anatomical images suggests that there is a degree of dissociation during illness between small progressive anatomical changes and some functional recovery indexed by scalp recordings from patients with an onset in adolescence 15 years before compared to adolescents in their first episode. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81528
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOknina, LBen_HK
dc.contributor.authorWildWall, Nen_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorJuran, SAen_HK
dc.contributor.authorRöpcke, Ben_HK
dc.contributor.authorPfueller, Uen_HK
dc.contributor.authorWeisbrod, Men_HK
dc.contributor.authorChan, Een_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2010-09-06T08:18:53Z-
dc.date.available2010-09-06T08:18:53Z-
dc.date.issued2005en_HK
dc.identifier.citationSchizophrenia Research, 2005, v. 76 n. 1, p. 25-41en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81528-
dc.description.abstractMismatch negativity (MMN) is an event-related potential measure of auditory change detection. It is widely reported to be smaller in patients with schizophrenia and may not improve along with otherwise successful clinical treatment. The main aim of this report is to explore ways of measuring and presenting four features of frequency-deviant MMN dipole sources (dipole moment, peak latency, brain location and orientation) and to relate these to the processes of psychopathology and illness progression. Data from early onset patients (EOS) at the start of the illness in adolescence, and others who had their first break in adolescence 15 years ago (S-15Y) were compared with two groups of age-matched healthy controls (C-EOS, C-15Y). A four-source model fitted the MMN waveform recorded from all four groups, whether MMN amplitude was more (EOS) or less (S-15Y) reduced. The locations were in the left superior temporal and anterior cingulate gyri, right superior temporal and inferior/mid frontal cortices. Dipole latencies confirmed a bottom-up sequence of processing and dipole moments were larger in the temporal lobes and on the left. Patients showed small dipole location changes that were more marked in the S-15Y than the EOS group (more rostral for the left anterior cingulate, more caudal for the right mid-frontal dipole) consistent with illness progression. The modelling of MMN dipole sources on brain atlas and anatomical images suggests that there is a degree of dissociation during illness between small progressive anatomical changes and some functional recovery indexed by scalp recordings from patients with an onset in adolescence 15 years before compared to adolescents in their first episode. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.subjectAttentionen_HK
dc.subjectCingulateen_HK
dc.subjectDipoleen_HK
dc.subjectFrontal cortexen_HK
dc.subjectMismatch Negativity (MMN)en_HK
dc.subjectSchizophreniaen_HK
dc.titleFrontal and temporal sources of mismatch negativity in healthy controls, patients at onset of schizophrenia in adolescence and others at 15 years after onseten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=76&spage=25&epage=41&date=2005&atitle=Frontal+and+temporal+sources+of+mismatch+negativity+in+healthy+control,+patients+at+onset+of+schizophrenia+in+adolescence+and+others+at+15+years+after+onseten_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2004.10.003en_HK
dc.identifier.pmid15927796-
dc.identifier.scopuseid_2-s2.0-20444502097en_HK
dc.identifier.hkuros116302en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444502097&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000229897400002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridOknina, LB=6602961277en_HK
dc.identifier.scopusauthoridWildWall, N=23470982000en_HK
dc.identifier.scopusauthoridOades, RD=7006782221en_HK
dc.identifier.scopusauthoridJuran, SA=8697570100en_HK
dc.identifier.scopusauthoridRöpcke, B=6603265880en_HK
dc.identifier.scopusauthoridPfueller, U=6603566992en_HK
dc.identifier.scopusauthoridWeisbrod, M=7003679476en_HK
dc.identifier.scopusauthoridChan, E=8629722500en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK

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