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Article: Genetic overlap between P300, P50, and duration mismatch negativity

TitleGenetic overlap between P300, P50, and duration mismatch negativity
Authors
KeywordsEndophenotype
ERPs
Multivariate genetic analysis
Twins
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2006, v. 141 n. 4, p. 336-343 How to Cite?
AbstractMismatch Negativity (MMN), P300, and P50 suppression event-related potential (ERP) components measure intermediate stages of information processing but little is known of how they relate to each other genetically. The present study used multivariate genetic model fitting analytic techniques in 46 monozygotic and 32 dizygotic twin pairs. P300, P50 suppression, and MMN were recorded using a 19-channel electroencephalograph (EEG). Zygosity was determined using DNA genotyping. Little evidence for either genetic or environmental association between each of the three ERP paradigms was found. This result suggests that P300, MMN, and P50 suppression serve to evaluate different brain information processing functions that may be mediated by distinct neurobiological mechanisms which in turn are influenced by different sets of genes. Within paradigm, P300 amplitude and latency shared about half of their genetic effects. © 2006 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/81519
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHall, MHen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.date.accessioned2010-09-06T08:18:45Z-
dc.date.available2010-09-06T08:18:45Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2006, v. 141 n. 4, p. 336-343en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81519-
dc.description.abstractMismatch Negativity (MMN), P300, and P50 suppression event-related potential (ERP) components measure intermediate stages of information processing but little is known of how they relate to each other genetically. The present study used multivariate genetic model fitting analytic techniques in 46 monozygotic and 32 dizygotic twin pairs. P300, P50 suppression, and MMN were recorded using a 19-channel electroencephalograph (EEG). Zygosity was determined using DNA genotyping. Little evidence for either genetic or environmental association between each of the three ERP paradigms was found. This result suggests that P300, MMN, and P50 suppression serve to evaluate different brain information processing functions that may be mediated by distinct neurobiological mechanisms which in turn are influenced by different sets of genes. Within paradigm, P300 amplitude and latency shared about half of their genetic effects. © 2006 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectEndophenotypeen_HK
dc.subjectERPsen_HK
dc.subjectMultivariate genetic analysisen_HK
dc.subjectTwinsen_HK
dc.titleGenetic overlap between P300, P50, and duration mismatch negativityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4841&volume=141&issue=B&spage=336&epage=343&date=2006&atitle=Genetic+overlap+between+P300,+P50+and+duration+mismatch+negativityen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ajmg.b.30318en_HK
dc.identifier.pmid16649211-
dc.identifier.scopuseid_2-s2.0-33745029119en_HK
dc.identifier.hkuros133755en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745029119&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume141en_HK
dc.identifier.issue4en_HK
dc.identifier.spage336en_HK
dc.identifier.epage343en_HK
dc.identifier.isiWOS:000238054200004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK

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