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Article: Population differences in the international multi-centre ADHD gene project

TitlePopulation differences in the international multi-centre ADHD gene project
Authors
KeywordsHapMap
Linkage disequilibrium
Tagging
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
Citation
Genetic Epidemiology, 2008, v. 32 n. 2, p. 98-107 How to Cite?
Abstract
The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nominally significant tests. Hardy-Weinberg equilibrium tests suggest that combining all these populations would induce stratification, but that the Northern European populations (Belgium, England, Germany, Holland, and Ireland) could be appropriate. Tag SNPs were generated using pair-wise and aggressive tagging from Carlson et al. [2004] and de Bakker et al. [2005], respectively, in each population and applied to the other populations. Cross-population performance across Northern Europe was consistent with within population comparisons. Smaller sample size for each population tended to yield more problems for the generation of aggressive tags and the application of pair-wise tags. Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations. © 2007 Wiley-Liss, Inc.
DescriptionErratum in Genet Epidemiol. 2008 Feb;32(2):186.
Persistent Identifierhttp://hdl.handle.net/10722/81516
ISSN
2013 Impact Factor: 2.951
ISI Accession Number ID
References

 

Author Affiliations
  1. Geha Mental Health Center
  2. King's College London
  3. Trinity College Dublin
  4. Massachusetts General Hospital
  5. The University of Hong Kong
  6. Universiteit Gent
  7. University of Southampton
  8. Universität Göttingen
  9. Herzog Hospital Jerusalem
  10. Universitat de Valencia
  11. Universitäts Klinikum Essen und Medizinische Fakultät
  12. Vrije Universiteit Amsterdam
  13. Radboud University Nijmegen Medical Centre
  14. Universität Zürich
  15. State University of New York Upstate Medical University
  16. Broad Institute
DC FieldValueLanguage
dc.contributor.authorNeale, BMen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorPurcell, Sen_HK
dc.contributor.authorBanaschewski, Ten_HK
dc.contributor.authorBuitelaar, Jen_HK
dc.contributor.authorFranke, Ben_HK
dc.contributor.authorSonugaBarke, Een_HK
dc.contributor.authorEbstein, Ren_HK
dc.contributor.authorEisenberg, Jen_HK
dc.contributor.authorMulligan, Aen_HK
dc.contributor.authorGill, Men_HK
dc.contributor.authorManor, Ien_HK
dc.contributor.authorMiranda, Aen_HK
dc.contributor.authorMulas, Fen_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorRoeyers, Hen_HK
dc.contributor.authorRothenberger, Aen_HK
dc.contributor.authorSergeant, Jen_HK
dc.contributor.authorSteinhausen, HCen_HK
dc.contributor.authorTaylor, Een_HK
dc.contributor.authorThompson, Men_HK
dc.contributor.authorZhou, Ken_HK
dc.contributor.authorAsherson, Pen_HK
dc.contributor.authorFaraone, SVen_HK
dc.date.accessioned2010-09-06T08:18:43Z-
dc.date.available2010-09-06T08:18:43Z-
dc.date.issued2008en_HK
dc.identifier.citationGenetic Epidemiology, 2008, v. 32 n. 2, p. 98-107en_HK
dc.identifier.issn0741-0395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81516-
dc.descriptionErratum in Genet Epidemiol. 2008 Feb;32(2):186.-
dc.description.abstractThe International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nominally significant tests. Hardy-Weinberg equilibrium tests suggest that combining all these populations would induce stratification, but that the Northern European populations (Belgium, England, Germany, Holland, and Ireland) could be appropriate. Tag SNPs were generated using pair-wise and aggressive tagging from Carlson et al. [2004] and de Bakker et al. [2005], respectively, in each population and applied to the other populations. Cross-population performance across Northern Europe was consistent with within population comparisons. Smaller sample size for each population tended to yield more problems for the generation of aggressive tags and the application of pair-wise tags. Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841en_HK
dc.relation.ispartofGenetic Epidemiologyen_HK
dc.rightsGenetic Epidemiology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectHapMapen_HK
dc.subjectLinkage disequilibriumen_HK
dc.subjectTaggingen_HK
dc.subject.meshAttention Deficit Disorder with Hyperactivity - genetics-
dc.subject.meshChromosome Mapping-
dc.subject.meshGene Frequency-
dc.subject.meshLinkage Disequilibrium-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titlePopulation differences in the international multi-centre ADHD gene projecten_HK
dc.typeArticleen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/gepi.20265en_HK
dc.identifier.pmid17868146en_HK
dc.identifier.scopuseid_2-s2.0-39649089398en_HK
dc.identifier.hkuros151810en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39649089398&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue2en_HK
dc.identifier.spage98en_HK
dc.identifier.epage107en_HK
dc.identifier.isiWOS:000253306500002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNeale, BM=7003484514en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridPurcell, S=7005489464en_HK
dc.identifier.scopusauthoridBanaschewski, T=6603935963en_HK
dc.identifier.scopusauthoridBuitelaar, J=26640178500en_HK
dc.identifier.scopusauthoridFranke, B=7005326255en_HK
dc.identifier.scopusauthoridSonugaBarke, E=7005682785en_HK
dc.identifier.scopusauthoridEbstein, R=7007152650en_HK
dc.identifier.scopusauthoridEisenberg, J=7102686191en_HK
dc.identifier.scopusauthoridMulligan, A=23570979700en_HK
dc.identifier.scopusauthoridGill, M=35228962600en_HK
dc.identifier.scopusauthoridManor, I=6701576599en_HK
dc.identifier.scopusauthoridMiranda, A=35403188200en_HK
dc.identifier.scopusauthoridMulas, F=7004054009en_HK
dc.identifier.scopusauthoridOades, RD=7006782221en_HK
dc.identifier.scopusauthoridRoeyers, H=6701645061en_HK
dc.identifier.scopusauthoridRothenberger, A=7005835367en_HK
dc.identifier.scopusauthoridSergeant, J=7004036780en_HK
dc.identifier.scopusauthoridSteinhausen, HC=7102832892en_HK
dc.identifier.scopusauthoridTaylor, E=7403206584en_HK
dc.identifier.scopusauthoridThompson, M=14526195300en_HK
dc.identifier.scopusauthoridZhou, K=22837296400en_HK
dc.identifier.scopusauthoridAsherson, P=35402700900en_HK
dc.identifier.scopusauthoridFaraone, SV=36047714700en_HK
dc.identifier.citeulike4044063-

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