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Article: Population differences in the international multi-centre ADHD gene project
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TitlePopulation differences in the international multi-centre ADHD gene project
 
AuthorsNeale, BM2
Sham, PC5
Purcell, S4 16
Banaschewski, T8
Buitelaar, J13
Franke, B13
SonugaBarke, E7
Ebstein, R1
Eisenberg, J9
Mulligan, A3
Gill, M3
Manor, I1
Miranda, A10
Mulas, F10
Oades, RD11
Roeyers, H6
Rothenberger, A8
Sergeant, J12
Steinhausen, HC14
Taylor, E11
Thompson, M7
Zhou, K2
Asherson, P2
Faraone, SV15
 
KeywordsHapMap
Linkage disequilibrium
Tagging
 
Issue Date2008
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
 
CitationGenetic Epidemiology, 2008, v. 32 n. 2, p. 98-107 [How to Cite?]
DOI: http://dx.doi.org/10.1002/gepi.20265
 
AbstractThe International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nominally significant tests. Hardy-Weinberg equilibrium tests suggest that combining all these populations would induce stratification, but that the Northern European populations (Belgium, England, Germany, Holland, and Ireland) could be appropriate. Tag SNPs were generated using pair-wise and aggressive tagging from Carlson et al. [2004] and de Bakker et al. [2005], respectively, in each population and applied to the other populations. Cross-population performance across Northern Europe was consistent with within population comparisons. Smaller sample size for each population tended to yield more problems for the generation of aggressive tags and the application of pair-wise tags. Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations. © 2007 Wiley-Liss, Inc.
 
DescriptionErratum in Genet Epidemiol. 2008 Feb;32(2):186.
 
ISSN0741-0395
2013 Impact Factor: 2.951
 
DOIhttp://dx.doi.org/10.1002/gepi.20265
 
ISI Accession Number IDWOS:000253306500002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNeale, BM
 
dc.contributor.authorSham, PC
 
dc.contributor.authorPurcell, S
 
dc.contributor.authorBanaschewski, T
 
dc.contributor.authorBuitelaar, J
 
dc.contributor.authorFranke, B
 
dc.contributor.authorSonugaBarke, E
 
dc.contributor.authorEbstein, R
 
dc.contributor.authorEisenberg, J
 
dc.contributor.authorMulligan, A
 
dc.contributor.authorGill, M
 
dc.contributor.authorManor, I
 
dc.contributor.authorMiranda, A
 
dc.contributor.authorMulas, F
 
dc.contributor.authorOades, RD
 
dc.contributor.authorRoeyers, H
 
dc.contributor.authorRothenberger, A
 
dc.contributor.authorSergeant, J
 
dc.contributor.authorSteinhausen, HC
 
dc.contributor.authorTaylor, E
 
dc.contributor.authorThompson, M
 
dc.contributor.authorZhou, K
 
dc.contributor.authorAsherson, P
 
dc.contributor.authorFaraone, SV
 
dc.date.accessioned2010-09-06T08:18:43Z
 
dc.date.available2010-09-06T08:18:43Z
 
dc.date.issued2008
 
dc.description.abstractThe International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nominally significant tests. Hardy-Weinberg equilibrium tests suggest that combining all these populations would induce stratification, but that the Northern European populations (Belgium, England, Germany, Holland, and Ireland) could be appropriate. Tag SNPs were generated using pair-wise and aggressive tagging from Carlson et al. [2004] and de Bakker et al. [2005], respectively, in each population and applied to the other populations. Cross-population performance across Northern Europe was consistent with within population comparisons. Smaller sample size for each population tended to yield more problems for the generation of aggressive tags and the application of pair-wise tags. Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations. © 2007 Wiley-Liss, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.descriptionErratum in Genet Epidemiol. 2008 Feb;32(2):186.
 
dc.identifier.citationGenetic Epidemiology, 2008, v. 32 n. 2, p. 98-107 [How to Cite?]
DOI: http://dx.doi.org/10.1002/gepi.20265
 
dc.identifier.citeulike4044063
 
dc.identifier.doihttp://dx.doi.org/10.1002/gepi.20265
 
dc.identifier.epage107
 
dc.identifier.hkuros151810
 
dc.identifier.isiWOS:000253306500002
 
dc.identifier.issn0741-0395
2013 Impact Factor: 2.951
 
dc.identifier.issue2
 
dc.identifier.pmid17868146
 
dc.identifier.scopuseid_2-s2.0-39649089398
 
dc.identifier.spage98
 
dc.identifier.urihttp://hdl.handle.net/10722/81516
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
 
dc.publisher.placeUnited States
 
dc.relation.ispartofGenetic Epidemiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsGenetic Epidemiology. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshAttention Deficit Disorder with Hyperactivity - genetics
 
dc.subject.meshChromosome Mapping
 
dc.subject.meshGene Frequency
 
dc.subject.meshLinkage Disequilibrium
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subjectHapMap
 
dc.subjectLinkage disequilibrium
 
dc.subjectTagging
 
dc.titlePopulation differences in the international multi-centre ADHD gene project
 
dc.typeArticle
 
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<contributor.author>SonugaBarke, E</contributor.author>
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Author Affiliations
  1. Geha Mental Health Center
  2. King's College London
  3. Trinity College Dublin
  4. Massachusetts General Hospital
  5. The University of Hong Kong
  6. Universiteit Gent
  7. University of Southampton
  8. Universität Göttingen
  9. Herzog Hospital Jerusalem
  10. Universitat de Valencia
  11. Universitäts Klinikum Essen und Medizinische Fakultät
  12. Vrije Universiteit Amsterdam
  13. Radboud University Nijmegen Medical Centre
  14. Universität Zürich
  15. State University of New York Upstate Medical University
  16. Broad Institute