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Article: Substantial shared genetic influences on schizophrenia and event-related potentials

TitleSubstantial shared genetic influences on schizophrenia and event-related potentials
Authors
Issue Date2007
PublisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.org
Citation
American Journal Of Psychiatry, 2007, v. 164 n. 5, p. 804-812 How to Cite?
AbstractObjective: Several components of event-related potentials - P50 suppression, P300 amplitude and latency, and mismatch negativity - have been proposed as potential endophenotypes for schizophrenia on the basis of family studies. The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia. Method: The authors measured mismatch negativity, P300, and P50 suppression in 16 monozygotic twin pairs concordant for schizophrenia, nine monozygotic twin pairs discordant for schizophrenia, and 78 healthy comparison twin pairs. The study design was based on a power calculation. Structural equation modeling was used to quantify the genetic and environmental contributions to the phenotypic covariance between schizophrenia and each of the event-related potential indices. Results: Significant phenotypic correlation with schizophrenia was found for each of the event-related potential components. Genetic factors were the main source of the phenotypic correlations. P50 suppression had the greatest genetic correlation with schizophrenia, followed by P300 amplitude, P300 latency, and mismatch negativity. Conclusions: All four event-related potential indices are potentially valid endophenotypes for schizophrenia, but P50 suppression and P300 amplitude show the closest genetic relationship to schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/81508
ISSN
2015 Impact Factor: 13.505
2015 SCImago Journal Rankings: 5.218
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHall, MHen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorSham, Pen_HK
dc.date.accessioned2010-09-06T08:18:37Z-
dc.date.available2010-09-06T08:18:37Z-
dc.date.issued2007en_HK
dc.identifier.citationAmerican Journal Of Psychiatry, 2007, v. 164 n. 5, p. 804-812en_HK
dc.identifier.issn0002-953Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/81508-
dc.description.abstractObjective: Several components of event-related potentials - P50 suppression, P300 amplitude and latency, and mismatch negativity - have been proposed as potential endophenotypes for schizophrenia on the basis of family studies. The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia. Method: The authors measured mismatch negativity, P300, and P50 suppression in 16 monozygotic twin pairs concordant for schizophrenia, nine monozygotic twin pairs discordant for schizophrenia, and 78 healthy comparison twin pairs. The study design was based on a power calculation. Structural equation modeling was used to quantify the genetic and environmental contributions to the phenotypic covariance between schizophrenia and each of the event-related potential indices. Results: Significant phenotypic correlation with schizophrenia was found for each of the event-related potential components. Genetic factors were the main source of the phenotypic correlations. P50 suppression had the greatest genetic correlation with schizophrenia, followed by P300 amplitude, P300 latency, and mismatch negativity. Conclusions: All four event-related potential indices are potentially valid endophenotypes for schizophrenia, but P50 suppression and P300 amplitude show the closest genetic relationship to schizophrenia.en_HK
dc.languageengen_HK
dc.publisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.orgen_HK
dc.relation.ispartofAmerican Journal of Psychiatryen_HK
dc.titleSubstantial shared genetic influences on schizophrenia and event-related potentialsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-953X&volume=164&issue=5&spage=804&epage=812&date=2007&atitle=Substantial+shared+genetic+influences+on+schizophrenia+and+event-related+potentialsen_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1176/appi.ajp.164.5.804en_HK
dc.identifier.pmid17475740-
dc.identifier.scopuseid_2-s2.0-34249296342en_HK
dc.identifier.hkuros133089en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249296342&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume164en_HK
dc.identifier.issue5en_HK
dc.identifier.spage804en_HK
dc.identifier.epage812en_HK
dc.identifier.isiWOS:000246370300021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK

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