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Article: Asperger syndrome: A proton magnetic resonance spectroscopy study of brain

TitleAsperger syndrome: A proton magnetic resonance spectroscopy study of brain
Authors
Issue Date2002
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.com
Citation
Archives Of General Psychiatry, 2002, v. 59 n. 10, p. 885-891 How to Cite?
AbstractBackground: Asperger syndrome (AS; an autistic disorder) is associated with impaired social skills and obsessional/repetitive behavior. Patients with autism have significant abnormalities in the frontal lobe and front-oparietal connectivity. Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS. Methods: We used in vivo proton magnetic resonance spectroscopy to examine neuronal integrity of the medial prefrontal and parietal lobes in 14 non-learning-disabled adults with AS and 18 control subjects (of similar sex, age, and IQ). We obtained measures of the prefrontal lobe in 11, the parietal lobe in 13, and both lobes in 10 subjects with AS. We measured concentrations and ratios of N-acetylaspartate (NAA), creatine and phosphocreatine (Cr+PCr), and choline (Cho). Levels of NAA, Cr+PCr, and Cho are indicators of neuronal density and mitochondrial metabolism, phosphate metabolism, and membrane turnover. Frontal metabolite levels were correlated with scores on the Yale-Brown Obsessive Compulsive Scale and the Autism Diagnostic Interview. Results: Subjects with AS had a significantly higher prefrontal lobe concentration of NAA (z=-3.1; P=.002), Cr+PCr (z=-2.2; P=.03), and Cho (z=-2.9; P=.003). Increased prefrontal NAA concentration was significantly correlated with obsessional behavior (τ=0.67; P=.005); increased prefrontal concentration of Cho, with social function (τ = 0.72; P =.02). We found no significant differences in parietal lobe metabolite concentrations. Conclusion: Subjects with AS have abnormalities in neuronal integrity of the prefrontal lobe, which is related to severity of clinical symptoms.
Persistent Identifierhttp://hdl.handle.net/10722/81506
ISSN
2014 Impact Factor: 14.48
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMurphy, DGMen_HK
dc.contributor.authorCritchley, HDen_HK
dc.contributor.authorSchmitz, Nen_HK
dc.contributor.authorMcAlonan, Gen_HK
dc.contributor.authorVan Amelsvoort, Ten_HK
dc.contributor.authorRobertson, Den_HK
dc.contributor.authorDaly, Een_HK
dc.contributor.authorRowe, Aen_HK
dc.contributor.authorRussell, Aen_HK
dc.contributor.authorSimmons, Aen_HK
dc.contributor.authorMurphy, KCen_HK
dc.contributor.authorHowlin, Pen_HK
dc.date.accessioned2010-09-06T08:18:35Z-
dc.date.available2010-09-06T08:18:35Z-
dc.date.issued2002en_HK
dc.identifier.citationArchives Of General Psychiatry, 2002, v. 59 n. 10, p. 885-891en_HK
dc.identifier.issn0003-990Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/81506-
dc.description.abstractBackground: Asperger syndrome (AS; an autistic disorder) is associated with impaired social skills and obsessional/repetitive behavior. Patients with autism have significant abnormalities in the frontal lobe and front-oparietal connectivity. Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS. Methods: We used in vivo proton magnetic resonance spectroscopy to examine neuronal integrity of the medial prefrontal and parietal lobes in 14 non-learning-disabled adults with AS and 18 control subjects (of similar sex, age, and IQ). We obtained measures of the prefrontal lobe in 11, the parietal lobe in 13, and both lobes in 10 subjects with AS. We measured concentrations and ratios of N-acetylaspartate (NAA), creatine and phosphocreatine (Cr+PCr), and choline (Cho). Levels of NAA, Cr+PCr, and Cho are indicators of neuronal density and mitochondrial metabolism, phosphate metabolism, and membrane turnover. Frontal metabolite levels were correlated with scores on the Yale-Brown Obsessive Compulsive Scale and the Autism Diagnostic Interview. Results: Subjects with AS had a significantly higher prefrontal lobe concentration of NAA (z=-3.1; P=.002), Cr+PCr (z=-2.2; P=.03), and Cho (z=-2.9; P=.003). Increased prefrontal NAA concentration was significantly correlated with obsessional behavior (τ=0.67; P=.005); increased prefrontal concentration of Cho, with social function (τ = 0.72; P =.02). We found no significant differences in parietal lobe metabolite concentrations. Conclusion: Subjects with AS have abnormalities in neuronal integrity of the prefrontal lobe, which is related to severity of clinical symptoms.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.comen_HK
dc.relation.ispartofArchives of General Psychiatryen_HK
dc.titleAsperger syndrome: A proton magnetic resonance spectroscopy study of brainen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-990X&volume=59&issue=10&spage=885&epage=&date=2002&atitle=Asperger+Syndrome:+A+proton+magnetic+resonance+spectroscopy+study+of+brainen_HK
dc.identifier.emailMcAlonan, G: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, G=rp00475en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12365875-
dc.identifier.scopuseid_2-s2.0-0036790746en_HK
dc.identifier.hkuros83195en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036790746&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue10en_HK
dc.identifier.spage885en_HK
dc.identifier.epage891en_HK
dc.identifier.isiWOS:000178493800003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMurphy, DGM=7404062227en_HK
dc.identifier.scopusauthoridCritchley, HD=7006731538en_HK
dc.identifier.scopusauthoridSchmitz, N=23467685900en_HK
dc.identifier.scopusauthoridMcAlonan, G=6603123011en_HK
dc.identifier.scopusauthoridVan Amelsvoort, T=6701774874en_HK
dc.identifier.scopusauthoridRobertson, D=7402818571en_HK
dc.identifier.scopusauthoridDaly, E=7101990804en_HK
dc.identifier.scopusauthoridRowe, A=7102335590en_HK
dc.identifier.scopusauthoridRussell, A=35556811900en_HK
dc.identifier.scopusauthoridSimmons, A=7101619950en_HK
dc.identifier.scopusauthoridMurphy, KC=7402863717en_HK
dc.identifier.scopusauthoridHowlin, P=7006180876en_HK

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