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Article: Positional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4

TitlePositional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4
Authors
KeywordsAssociation
Dickkopf
DKK
genetics
schizophrenia
wnt signaling
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2008, v. 63 n. 1, p. 13-16 How to Cite?
AbstractBackground: Wnt signaling has been implicated in schizophrenia from studies of gene expression in patients, from an understanding of the function of reported susceptibility genes and from experimental studies of psychoactive drugs. This diverse evidence suggests that wnt signaling genes, defined as pathway participants, modifiers or targets, are good candidates as susceptibility factors. Methods: We performed a combined positional and candidate association screen by identifying known wnt signaling genes in regions linked to schizophrenia. In a staged study we examined over 50 single nucleotide polymorphisms (SNPs) in 28 wnt signaling genes, first in trios of Chinese origin and then in a case-control series from Hong Kong. Results: In both sets, Dickkopf 4 (DKK4) was associated with schizophrenia - with an odds ratio of 3.9 (p < .01, CI = 1.3-11.1) in the combined sample. Conclusions: As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis. © 2008 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/81501
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorProitsi, Pen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorHamilton, Gen_HK
dc.contributor.authorDi Forti, Men_HK
dc.contributor.authorCollier, Den_HK
dc.contributor.authorKillick, Ren_HK
dc.contributor.authorChen, Ren_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorMurray, Ren_HK
dc.contributor.authorPowell, Jen_HK
dc.contributor.authorLovestone, Sen_HK
dc.date.accessioned2010-09-06T08:18:32Z-
dc.date.available2010-09-06T08:18:32Z-
dc.date.issued2008en_HK
dc.identifier.citationBiological Psychiatry, 2008, v. 63 n. 1, p. 13-16en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81501-
dc.description.abstractBackground: Wnt signaling has been implicated in schizophrenia from studies of gene expression in patients, from an understanding of the function of reported susceptibility genes and from experimental studies of psychoactive drugs. This diverse evidence suggests that wnt signaling genes, defined as pathway participants, modifiers or targets, are good candidates as susceptibility factors. Methods: We performed a combined positional and candidate association screen by identifying known wnt signaling genes in regions linked to schizophrenia. In a staged study we examined over 50 single nucleotide polymorphisms (SNPs) in 28 wnt signaling genes, first in trios of Chinese origin and then in a case-control series from Hong Kong. Results: In both sets, Dickkopf 4 (DKK4) was associated with schizophrenia - with an odds ratio of 3.9 (p < .01, CI = 1.3-11.1) in the combined sample. Conclusions: As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis. © 2008 Society of Biological Psychiatry.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.subjectAssociationen_HK
dc.subjectDickkopfen_HK
dc.subjectDKKen_HK
dc.subjectgeneticsen_HK
dc.subjectschizophreniaen_HK
dc.subjectwnt signalingen_HK
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshIntercellular Signaling Peptides and Proteins - genetics-
dc.subject.meshSchizophrenia - genetics-
dc.subject.meshSignal Transduction - genetics-
dc.subject.meshWnt Proteins - genetics - metabolism-
dc.titlePositional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3223&volume=63&issue=1&spage=13&epage=16&date=2008&atitle=Positional+pathway+screen+of+wnt+signaling+genes+in+schizophrenia:+Association+with+DKK4en_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biopsych.2007.03.014en_HK
dc.identifier.pmid17553464en_HK
dc.identifier.scopuseid_2-s2.0-36849084966en_HK
dc.identifier.hkuros143649en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36849084966&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage16en_HK
dc.identifier.isiWOS:000251864000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridProitsi, P=23035958100en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridHamilton, G=7201369107en_HK
dc.identifier.scopusauthoridDi Forti, M=10738849300en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK
dc.identifier.scopusauthoridKillick, R=6701630759en_HK
dc.identifier.scopusauthoridChen, R=16635066600en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK
dc.identifier.scopusauthoridPowell, J=7403541196en_HK
dc.identifier.scopusauthoridLovestone, S=7005575001en_HK
dc.identifier.citeulike5226511-

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