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Article: A haplotype map of the human genome
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TitleA haplotype map of the human genome
 
AuthorsBelmont, JW4
Boudreau, A38
Leal, SM4
Hardenbol, P38
Pasternak, S4
Wheeler, DA4
Willis, TD38
Yu, F4
Yang, H30
Gao, Y30
Hu, H30
Wang, Y15
Wang, Y15
Xiong, X15
Xu, L15
Waye, MMY50
Tsui, SKW50
Xue, H39
Wong, JTF39
Galver, LM49
Barrett, J6 55
Sodergren, E4
Fan, JB49
Murray, SS49
Oliphant, AR
Chee, MS27
Montpetit, A52
Chagnon, F52
Ferretti, V52
Leboeuf, M52
Olivier, JF52
Phillips, MS52
Weinstock, GM4
Fry, B55
Roumy, S52
Sallée, C56
Verner, A52
Hudson, TJ52
Frazer, KA14
Ballinger, DG14
Cox, DR14
Hinds, DA14
Stuve, LL14
Yakub, I4
Kwok, PY3
Hu, W30
Cai, D3
Koboldt, DC34
Miller, RD34
Pawlikowska, L3
TaillonMiller, P34
Xiao, M3
Tsui, LC17
Mak, W17
Gabriel, SB55
Sham, PC17
Song, YQ17
Maller, J6 55
Tam, PKH17
Nakamura, Y28 22
Kawaguchi, T22
Kitamoto, T22
Morizono, T22
Nagashima, A22
Ohnishi, Y22
Onofrio, RC55
Sekine, A22
Tanaka, T22
Deloukas, P25
McCarroll, S6 55
Bird, CP25
Delgado, M25
Dermitzakis, ET25
Patterson, N55
Pe'er, I6 55
Purcell, S6
Ziaugra, L55
Richter, DJ55
Sabeti, P55
Saxena, R6 55
Schaffner, SF55
Varilly, P55
Li, C30
Stein, LD7
Krishnan, L7
Smith, AV7
Thorisson, GA7
Birren, BW55
Chakravarti, A48
Chen, PE48
Cutler, DJ48
Kashuk, CS48
Lin, S48
Abecasis, GR36
Lin, W30
Guan, W36
Munro, HM36
Qin, ZS36
Daly, MJ6 55
Thomas, DJ44
McVean, G40
Bottolo, L40
Eyheramendy, S40
Freeman, C40
Marchini, J40
Myers, S40
Liu, S30
Spencer, C40
Stephens, M46
Wilson, RK34
Donnelly, P40
Cardon, LR24
Clarke, G24
Evans, DM24
Morris, AP24
Weir, BS23
Tsunoda, T22
Mullikin, JC8
Pan, H30
Sherry, ST31
Yu, J30
Feolo, M31
Zhang, H2
Zeng, C30
Zhao, H30
Matsuda, I33
Fukushima, Y47
Macer, DR1
Suda, E10
Rotimi, CN20
Tang, X30
Gwilliam, R25
Adebamowo, CA21
Ajayi, I21
Aniagwu, T21
Marshall, PA42
Nkwodimmah, C21
Royal, CDM20
Leppert, MF41
Dixon, M41
Peiffer, A41
Qiu, R5
Fulton, LL34
Wang, J30
Kent, A35
Kato, K37
Niikawa, N13
Adewole, IF21
Knoppers, BM56
Foster, MW12
Clayton, EW45
Watkin, J9
Gibbs, RA4
Rogers, J25
Muzny, D4
Wang, W30
Nazareth, L4
Burton, J25
Carter, NP25
Clee, CM25
Griffiths, M25
Jones, MC25
McLay, K25
Plumb, RW25
Ross, MT25
Hunt, S25
Zhang, B30
Sims, SK25
Willey, DL25
Chen, Z30
Han, H30
Kang, L30
Godbout, M43
Wallenburg, JC52
L'Archevêque, P
Bellemare, G
Morrison, J25
Saeki, K11
Zhang, Q30
Wang, H15
An, D53
Fu, H53
Li, Q53
Wang, Z53
Wang, R18
Holden, AL19
Brooks, LD8
Powell, D25
McEwen, JE8
Bird, CR8
Zhao, H30
Guyer, MS8
Nailer, PJ8
Wang, VO8
Peterson, JL8
Shi, M29
Spiegel, J51
Sung, LM32
Stranger, BE25
Witonsky, J54
Zacharia, LF8
Collins, FS8
Zhou, J30
Kennedy, K9
Jamieson, R9
Stewart, J9
Barry, R55
Blumenstiel, B55
Camargo, A55
Whittaker, P25
Defelice, M55
Faggart, M55
Goyette, M55
Gupta, S55
Moore, J55
Nguyen, H55
Parkin, M55
Roy, J55
Stahl, E55
Winchester, E55
Bentley, DR16
Altshuler, D6 55
Shen, Y26
Yao, Z26
Huang, W15
Chu, X15
He, Y15
Jin, L15
Liu, Y15
Shen, Y15
Sun, W15
De Bakker, PIW6 55
Wang, H53
 
Issue Date2005
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
 
CitationNature, 2005, v. 437 n. 7063, p. 1299-1320 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nature04226
 
AbstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group.
 
ISSN0028-0836
2013 Impact Factor: 42.351
 
DOIhttp://dx.doi.org/10.1038/nature04226
 
PubMed Central IDPMC1880871
 
ISI Accession Number IDWOS:000232829100044
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBelmont, JW
 
dc.contributor.authorBoudreau, A
 
dc.contributor.authorLeal, SM
 
dc.contributor.authorHardenbol, P
 
dc.contributor.authorPasternak, S
 
dc.contributor.authorWheeler, DA
 
dc.contributor.authorWillis, TD
 
dc.contributor.authorYu, F
 
dc.contributor.authorYang, H
 
dc.contributor.authorGao, Y
 
dc.contributor.authorHu, H
 
dc.contributor.authorWang, Y
 
dc.contributor.authorWang, Y
 
dc.contributor.authorXiong, X
 
dc.contributor.authorXu, L
 
dc.contributor.authorWaye, MMY
 
dc.contributor.authorTsui, SKW
 
dc.contributor.authorXue, H
 
dc.contributor.authorWong, JTF
 
dc.contributor.authorGalver, LM
 
dc.contributor.authorBarrett, J
 
dc.contributor.authorSodergren, E
 
dc.contributor.authorFan, JB
 
dc.contributor.authorMurray, SS
 
dc.contributor.authorOliphant, AR
 
dc.contributor.authorChee, MS
 
dc.contributor.authorMontpetit, A
 
dc.contributor.authorChagnon, F
 
dc.contributor.authorFerretti, V
 
dc.contributor.authorLeboeuf, M
 
dc.contributor.authorOlivier, JF
 
dc.contributor.authorPhillips, MS
 
dc.contributor.authorWeinstock, GM
 
dc.contributor.authorFry, B
 
dc.contributor.authorRoumy, S
 
dc.contributor.authorSallée, C
 
dc.contributor.authorVerner, A
 
dc.contributor.authorHudson, TJ
 
dc.contributor.authorFrazer, KA
 
dc.contributor.authorBallinger, DG
 
dc.contributor.authorCox, DR
 
dc.contributor.authorHinds, DA
 
dc.contributor.authorStuve, LL
 
dc.contributor.authorYakub, I
 
dc.contributor.authorKwok, PY
 
dc.contributor.authorHu, W
 
dc.contributor.authorCai, D
 
dc.contributor.authorKoboldt, DC
 
dc.contributor.authorMiller, RD
 
dc.contributor.authorPawlikowska, L
 
dc.contributor.authorTaillonMiller, P
 
dc.contributor.authorXiao, M
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorMak, W
 
dc.contributor.authorGabriel, SB
 
dc.contributor.authorSham, PC
 
dc.contributor.authorSong, YQ
 
dc.contributor.authorMaller, J
 
dc.contributor.authorTam, PKH
 
dc.contributor.authorNakamura, Y
 
dc.contributor.authorKawaguchi, T
 
dc.contributor.authorKitamoto, T
 
dc.contributor.authorMorizono, T
 
dc.contributor.authorNagashima, A
 
dc.contributor.authorOhnishi, Y
 
dc.contributor.authorOnofrio, RC
 
dc.contributor.authorSekine, A
 
dc.contributor.authorTanaka, T
 
dc.contributor.authorDeloukas, P
 
dc.contributor.authorMcCarroll, S
 
dc.contributor.authorBird, CP
 
dc.contributor.authorDelgado, M
 
dc.contributor.authorDermitzakis, ET
 
dc.contributor.authorPatterson, N
 
dc.contributor.authorPe'er, I
 
dc.contributor.authorPurcell, S
 
dc.contributor.authorZiaugra, L
 
dc.contributor.authorRichter, DJ
 
dc.contributor.authorSabeti, P
 
dc.contributor.authorSaxena, R
 
dc.contributor.authorSchaffner, SF
 
dc.contributor.authorVarilly, P
 
dc.contributor.authorLi, C
 
dc.contributor.authorStein, LD
 
dc.contributor.authorKrishnan, L
 
dc.contributor.authorSmith, AV
 
dc.contributor.authorThorisson, GA
 
dc.contributor.authorBirren, BW
 
dc.contributor.authorChakravarti, A
 
dc.contributor.authorChen, PE
 
dc.contributor.authorCutler, DJ
 
dc.contributor.authorKashuk, CS
 
dc.contributor.authorLin, S
 
dc.contributor.authorAbecasis, GR
 
dc.contributor.authorLin, W
 
dc.contributor.authorGuan, W
 
dc.contributor.authorMunro, HM
 
dc.contributor.authorQin, ZS
 
dc.contributor.authorDaly, MJ
 
dc.contributor.authorThomas, DJ
 
dc.contributor.authorMcVean, G
 
dc.contributor.authorBottolo, L
 
dc.contributor.authorEyheramendy, S
 
dc.contributor.authorFreeman, C
 
dc.contributor.authorMarchini, J
 
dc.contributor.authorMyers, S
 
dc.contributor.authorLiu, S
 
dc.contributor.authorSpencer, C
 
dc.contributor.authorStephens, M
 
dc.contributor.authorWilson, RK
 
dc.contributor.authorDonnelly, P
 
dc.contributor.authorCardon, LR
 
dc.contributor.authorClarke, G
 
dc.contributor.authorEvans, DM
 
dc.contributor.authorMorris, AP
 
dc.contributor.authorWeir, BS
 
dc.contributor.authorTsunoda, T
 
dc.contributor.authorMullikin, JC
 
dc.contributor.authorPan, H
 
dc.contributor.authorSherry, ST
 
dc.contributor.authorYu, J
 
dc.contributor.authorFeolo, M
 
dc.contributor.authorZhang, H
 
dc.contributor.authorZeng, C
 
dc.contributor.authorZhao, H
 
dc.contributor.authorMatsuda, I
 
dc.contributor.authorFukushima, Y
 
dc.contributor.authorMacer, DR
 
dc.contributor.authorSuda, E
 
dc.contributor.authorRotimi, CN
 
dc.contributor.authorTang, X
 
dc.contributor.authorGwilliam, R
 
dc.contributor.authorAdebamowo, CA
 
dc.contributor.authorAjayi, I
 
dc.contributor.authorAniagwu, T
 
dc.contributor.authorMarshall, PA
 
dc.contributor.authorNkwodimmah, C
 
dc.contributor.authorRoyal, CDM
 
dc.contributor.authorLeppert, MF
 
dc.contributor.authorDixon, M
 
dc.contributor.authorPeiffer, A
 
dc.contributor.authorQiu, R
 
dc.contributor.authorFulton, LL
 
dc.contributor.authorWang, J
 
dc.contributor.authorKent, A
 
dc.contributor.authorKato, K
 
dc.contributor.authorNiikawa, N
 
dc.contributor.authorAdewole, IF
 
dc.contributor.authorKnoppers, BM
 
dc.contributor.authorFoster, MW
 
dc.contributor.authorClayton, EW
 
dc.contributor.authorWatkin, J
 
dc.contributor.authorGibbs, RA
 
dc.contributor.authorRogers, J
 
dc.contributor.authorMuzny, D
 
dc.contributor.authorWang, W
 
dc.contributor.authorNazareth, L
 
dc.contributor.authorBurton, J
 
dc.contributor.authorCarter, NP
 
dc.contributor.authorClee, CM
 
dc.contributor.authorGriffiths, M
 
dc.contributor.authorJones, MC
 
dc.contributor.authorMcLay, K
 
dc.contributor.authorPlumb, RW
 
dc.contributor.authorRoss, MT
 
dc.contributor.authorHunt, S
 
dc.contributor.authorZhang, B
 
dc.contributor.authorSims, SK
 
dc.contributor.authorWilley, DL
 
dc.contributor.authorChen, Z
 
dc.contributor.authorHan, H
 
dc.contributor.authorKang, L
 
dc.contributor.authorGodbout, M
 
dc.contributor.authorWallenburg, JC
 
dc.contributor.authorL'Archevêque, P
 
dc.contributor.authorBellemare, G
 
dc.contributor.authorMorrison, J
 
dc.contributor.authorSaeki, K
 
dc.contributor.authorZhang, Q
 
dc.contributor.authorWang, H
 
dc.contributor.authorAn, D
 
dc.contributor.authorFu, H
 
dc.contributor.authorLi, Q
 
dc.contributor.authorWang, Z
 
dc.contributor.authorWang, R
 
dc.contributor.authorHolden, AL
 
dc.contributor.authorBrooks, LD
 
dc.contributor.authorPowell, D
 
dc.contributor.authorMcEwen, JE
 
dc.contributor.authorBird, CR
 
dc.contributor.authorZhao, H
 
dc.contributor.authorGuyer, MS
 
dc.contributor.authorNailer, PJ
 
dc.contributor.authorWang, VO
 
dc.contributor.authorPeterson, JL
 
dc.contributor.authorShi, M
 
dc.contributor.authorSpiegel, J
 
dc.contributor.authorSung, LM
 
dc.contributor.authorStranger, BE
 
dc.contributor.authorWitonsky, J
 
dc.contributor.authorZacharia, LF
 
dc.contributor.authorCollins, FS
 
dc.contributor.authorZhou, J
 
dc.contributor.authorKennedy, K
 
dc.contributor.authorJamieson, R
 
dc.contributor.authorStewart, J
 
dc.contributor.authorBarry, R
 
dc.contributor.authorBlumenstiel, B
 
dc.contributor.authorCamargo, A
 
dc.contributor.authorWhittaker, P
 
dc.contributor.authorDefelice, M
 
dc.contributor.authorFaggart, M
 
dc.contributor.authorGoyette, M
 
dc.contributor.authorGupta, S
 
dc.contributor.authorMoore, J
 
dc.contributor.authorNguyen, H
 
dc.contributor.authorParkin, M
 
dc.contributor.authorRoy, J
 
dc.contributor.authorStahl, E
 
dc.contributor.authorWinchester, E
 
dc.contributor.authorBentley, DR
 
dc.contributor.authorAltshuler, D
 
dc.contributor.authorShen, Y
 
dc.contributor.authorYao, Z
 
dc.contributor.authorHuang, W
 
dc.contributor.authorChu, X
 
dc.contributor.authorHe, Y
 
dc.contributor.authorJin, L
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorShen, Y
 
dc.contributor.authorSun, W
 
dc.contributor.authorDe Bakker, PIW
 
dc.contributor.authorWang, H
 
dc.date.accessioned2010-09-06T08:18:10Z
 
dc.date.available2010-09-06T08:18:10Z
 
dc.date.issued2005
 
dc.description.abstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationNature, 2005, v. 437 n. 7063, p. 1299-1320 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nature04226
 
dc.identifier.citeulike366486
 
dc.identifier.doihttp://dx.doi.org/10.1038/nature04226
 
dc.identifier.epage1320
 
dc.identifier.f10001028916
 
dc.identifier.f10001028916
 
dc.identifier.f10001028916
 
dc.identifier.hkuros110731
 
dc.identifier.isiWOS:000232829100044
 
dc.identifier.issn0028-0836
2013 Impact Factor: 42.351
 
dc.identifier.issue7063
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1880871
 
dc.identifier.pmid16255080
 
dc.identifier.scopuseid_2-s2.0-79959524146
 
dc.identifier.spage1299
 
dc.identifier.urihttp://hdl.handle.net/10722/81471
 
dc.identifier.volume437
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofNature
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshChromosomes, Human, Y - genetics
 
dc.subject.meshDNA, Mitochondrial - genetics
 
dc.subject.meshGenome, Human
 
dc.subject.meshHaplotypes - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.titleA haplotype map of the human genome
 
dc.typeArticle
 
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<contributor.author>Tsunoda, T</contributor.author>
<contributor.author>Mullikin, JC</contributor.author>
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<date.accessioned>2010-09-06T08:18:10Z</date.accessioned>
<date.available>2010-09-06T08:18:10Z</date.available>
<date.issued>2005</date.issued>
<identifier.citation>Nature, 2005, v. 437 n. 7063, p. 1299-1320</identifier.citation>
<identifier.issn>0028-0836</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/81471</identifier.uri>
<description.abstract>Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. &#169; 2005 Nature Publishing Group.</description.abstract>
<language>eng</language>
<publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/nature</publisher>
<relation.ispartof>Nature</relation.ispartof>
<subject.mesh>Chromosomes, Human, Y - genetics</subject.mesh>
<subject.mesh>DNA, Mitochondrial - genetics</subject.mesh>
<subject.mesh>Genome, Human</subject.mesh>
<subject.mesh>Haplotypes - genetics</subject.mesh>
<subject.mesh>Polymorphism, Single Nucleotide - genetics</subject.mesh>
<title>A haplotype map of the human genome</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0028-0836&amp;volume=437&amp;issue=7063&amp;spage=1299&amp;epage=1320&amp;date=2005&amp;atitle=A+haplotype+map+of+the+human+genome+(Co-PI+of+Hong+Kong+Centre+which+responsible+for+2.5%+of+genome)</identifier.openurl>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1038/nature04226</identifier.doi>
<identifier.pmid>16255080</identifier.pmid>
<identifier.pmcid>PMC1880871</identifier.pmcid>
<identifier.scopus>eid_2-s2.0-79959524146</identifier.scopus>
<identifier.hkuros>110731</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-79959524146&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>437</identifier.volume>
<identifier.issue>7063</identifier.issue>
<identifier.spage>1299</identifier.spage>
<identifier.epage>1320</identifier.epage>
<identifier.isi>WOS:000232829100044</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<identifier.f1000>1028916</identifier.f1000>
<identifier.f1000>1028916</identifier.f1000>
<identifier.f1000>1028916</identifier.f1000>
<identifier.citeulike>366486</identifier.citeulike>
<bitstream.url>http://hub.hku.hk/bitstream/10722/81471/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. Scientific and Cultural Organization Bangkok
  2. Beijing Normal University
  3. University of California, San Francisco
  4. Baylor College of Medicine
  5. Chinese Academy of Social Sciences
  6. Massachusetts General Hospital
  7. Cold Spring Harbor Laboratory
  8. National Human Genome Research Institute
  9. Wellcome Trust
  10. University of Tsukuba
  11. Japan Ministry of Education, Culture, Sports, Science and Technology
  12. University of Oklahoma
  13. Nagasaki University
  14. Perlegen Sciences, Inc.
  15. Chinese National Human Genome Center at Shanghai
  16. Solexa Ltd.
  17. The University of Hong Kong
  18. Human Genetic Resource Administration of China
  19. SNP Consortium
  20. Howard University
  21. University of Ibadan
  22. Riken
  23. North Carolina State University
  24. Wellcome Trust Centre for Human Genetics
  25. Wellcome Trust Sanger Institute
  26. null
  27. Prognosys Biosciences Inc.
  28. Institute of Medical Science The University of Tokyo
  29. Novartis Pharma
  30. Chinese Academy of Sciences
  31. National Center for Biotechnology Information
  32. University of Maryland, Baltimore
  33. Health Sciences University of Hokkaido
  34. Washington University in St. Louis School of Medicine
  35. Genetic Interest Group
  36. University of Michigan School of Public Health
  37. Kyoto University
  38. ParAllele BioScience
  39. Hong Kong University of Science and Technology
  40. University of Oxford
  41. University of Utah Health Sciences Center
  42. Case Western Reserve University
  43. null
  44. University of California, Santa Cruz
  45. Vanderbilt University
  46. University of Washington Seattle
  47. Shinshu University Faculty of Medicine
  48. The Johns Hopkins School of Medicine
  49. Illumina, Inc.
  50. Chinese University of Hong Kong
  51. National Institutes of Health, Bethesda
  52. McGill University
  53. Basic Research Service of the Ministry of Science and Technology of the P. R. China
  54. Frost &amp; Sullivan
  55. Broad Institute
  56. Université de Montréal