Article: A haplotype map of the human genome

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TitleA haplotype map of the human genome
AuthorsBelmont, JW5
Boudreau, A36
Leal, SM5
Hardenbol, P36
Pasternak, S5
Wheeler, DA5
Willis, TD36
Yu, F5
Yang, H31
Gao, Y31
Hu, H31
Wang, Y17
Wang, Y17
Xiong, X17
Xu, L17
Waye, MMY53
Tsui, SKW53
Xue, H41
Wong, JTF41
Galver, LM48
Barrett, J2 50
Sodergren, E5
Fan, JB48
Murray, SS48
Oliphant, AR
Chee, MS26
Montpetit, A55
Chagnon, F55
Ferretti, V55
Leboeuf, M55
Olivier, JF55
Phillips, MS55
Weinstock, GM5
Fry, B50
Roumy, S55
Sallée, C51
Verner, A55
Hudson, TJ55
Frazer, KA14
Ballinger, DG14
Cox, DR14
Hinds, DA14
Stuve, LL14
Yakub, I5
Kwok, PY3
Hu, W31
Cai, D3
Koboldt, DC29
Miller, RD29
Pawlikowska, L3
TaillonMiller, P29
Xiao, M3
Tsui, LC18
Mak, W18
Gabriel, SB50
Sham, PC18
Song, YQ18
Maller, J2 50
Tam, PKH18
Nakamura, Y23 30
Kawaguchi, T23
Kitamoto, T23
Morizono, T23
Nagashima, A23
Ohnishi, Y23
Onofrio, RC50
Sekine, A23
Tanaka, T23
Deloukas, P22
McCarroll, S2 50
Bird, CP22
Delgado, M22
Dermitzakis, ET22
Patterson, N50
Pe'er, I2 50
Purcell, S2
Ziaugra, L50
Richter, DJ50
Sabeti, P50
Saxena, R2 50
Schaffner, SF50
Varilly, P50
Li, C31
Stein, LD7
Krishnan, L7
Smith, AV7
Thorisson, GA7
Birren, BW50
Chakravarti, A47
Chen, PE47
Cutler, DJ47
Kashuk, CS47
Lin, S47
Abecasis, GR37
Lin, W31
Guan, W37
Munro, HM37
Qin, ZS37
Daly, MJ2 50
Thomas, DJ44
McVean, G42
Bottolo, L42
Eyheramendy, S42
Freeman, C42
Marchini, J42
Myers, S42
Liu, S31
Spencer, C42
Stephens, M45
Wilson, RK29
Donnelly, P42
Cardon, LR25
Clarke, G25
Evans, DM25
Morris, AP25
Weir, BS24
Tsunoda, T23
Mullikin, JC8
Pan, H31
Sherry, ST32
Yu, J31
Feolo, M32
Zhang, H4
Zeng, C31
Zhao, H31
Matsuda, I33
Fukushima, Y46
Macer, DR1
Suda, E10
Rotimi, CN21
Tang, X31
Gwilliam, R22
Adebamowo, CA20
Ajayi, I20
Aniagwu, T20
Marshall, PA39
Nkwodimmah, C20
Royal, CDM21
Leppert, MF43
Dixon, M43
Peiffer, A43
Qiu, R6
Fulton, LL29
Wang, J31
Kent, A35
Kato, K38
Niikawa, N16
Adewole, IF20
Knoppers, BM51
Foster, MW12
Clayton, EW49
Watkin, J9
Gibbs, RA5
Rogers, J22
Muzny, D5
Wang, W31
Nazareth, L5
Burton, J22
Carter, NP22
Clee, CM22
Griffiths, M22
Jones, MC22
McLay, K22
Plumb, RW22
Ross, MT22
Hunt, S22
Zhang, B31
Sims, SK22
Willey, DL22
Chen, Z31
Han, H31
Kang, L31
Godbout, M40
Wallenburg, JC55
L'Archevêque, P
Bellemare, G
Morrison, J22
Saeki, K11
Zhang, Q31
Wang, H17
An, D56
Fu, H56
Li, Q56
Wang, Z56
Wang, R13
Holden, AL19
Brooks, LD8
Powell, D22
McEwen, JE8
Bird, CR8
Zhao, H31
Guyer, MS8
Nailer, PJ8
Wang, VO8
Peterson, JL8
Shi, M34
Spiegel, J54
Sung, LM28
Stranger, BE22
Witonsky, J52
Zacharia, LF8
Collins, FS8
Zhou, J31
Kennedy, K9
Jamieson, R9
Stewart, J9
Barry, R50
Blumenstiel, B50
Camargo, A50
Whittaker, P22
Defelice, M50
Faggart, M50
Goyette, M50
Gupta, S50
Moore, J50
Nguyen, H50
Parkin, M50
Roy, J50
Stahl, E50
Winchester, E50
Bentley, DR15
Altshuler, D2 50
Shen, Y27
Yao, Z27
Huang, W17
Chu, X17
He, Y17
Jin, L17
Liu, Y17
Shen, Y17
Sun, W17
De Bakker, PIW2 50
Wang, H56
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
CitationNature, 2005, v. 437 n. 7063, p. 1299-1320 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nature04226
AbstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group.
ISSN0028-0836
2011 Impact Factor: 36.28
2011 SCImago Journal Rankings: 7.767
DOIhttp://dx.doi.org/10.1038/nature04226
ISI Accession Number IDWOS:000232829100044
PubMed Central IDPMC1880871
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorBelmont, JW
dc.contributor.authorBoudreau, A
dc.contributor.authorLeal, SM
dc.contributor.authorHardenbol, P
dc.contributor.authorPasternak, S
dc.contributor.authorWheeler, DA
dc.contributor.authorWillis, TD
dc.contributor.authorYu, F
dc.contributor.authorYang, H
dc.contributor.authorGao, Y
dc.contributor.authorHu, H
dc.contributor.authorWang, Y
dc.contributor.authorWang, Y
dc.contributor.authorXiong, X
dc.contributor.authorXu, L
dc.contributor.authorWaye, MMY
dc.contributor.authorTsui, SKW
dc.contributor.authorXue, H
dc.contributor.authorWong, JTF
dc.contributor.authorGalver, LM
dc.contributor.authorBarrett, J
dc.contributor.authorSodergren, E
dc.contributor.authorFan, JB
dc.contributor.authorMurray, SS
dc.contributor.authorOliphant, AR
dc.contributor.authorChee, MS
dc.contributor.authorMontpetit, A
dc.contributor.authorChagnon, F
dc.contributor.authorFerretti, V
dc.contributor.authorLeboeuf, M
dc.contributor.authorOlivier, JF
dc.contributor.authorPhillips, MS
dc.contributor.authorWeinstock, GM
dc.contributor.authorFry, B
dc.contributor.authorRoumy, S
dc.contributor.authorSallée, C
dc.contributor.authorVerner, A
dc.contributor.authorHudson, TJ
dc.contributor.authorFrazer, KA
dc.contributor.authorBallinger, DG
dc.contributor.authorCox, DR
dc.contributor.authorHinds, DA
dc.contributor.authorStuve, LL
dc.contributor.authorYakub, I
dc.contributor.authorKwok, PY
dc.contributor.authorHu, W
dc.contributor.authorCai, D
dc.contributor.authorKoboldt, DC
dc.contributor.authorMiller, RD
dc.contributor.authorPawlikowska, L
dc.contributor.authorTaillonMiller, P
dc.contributor.authorXiao, M
dc.contributor.authorTsui, LC
dc.contributor.authorMak, W
dc.contributor.authorGabriel, SB
dc.contributor.authorSham, PC
dc.contributor.authorSong, YQ
dc.contributor.authorMaller, J
dc.contributor.authorTam, PKH
dc.contributor.authorNakamura, Y
dc.contributor.authorKawaguchi, T
dc.contributor.authorKitamoto, T
dc.contributor.authorMorizono, T
dc.contributor.authorNagashima, A
dc.contributor.authorOhnishi, Y
dc.contributor.authorOnofrio, RC
dc.contributor.authorSekine, A
dc.contributor.authorTanaka, T
dc.contributor.authorDeloukas, P
dc.contributor.authorMcCarroll, S
dc.contributor.authorBird, CP
dc.contributor.authorDelgado, M
dc.contributor.authorDermitzakis, ET
dc.contributor.authorPatterson, N
dc.contributor.authorPe'er, I
dc.contributor.authorPurcell, S
dc.contributor.authorZiaugra, L
dc.contributor.authorRichter, DJ
dc.contributor.authorSabeti, P
dc.contributor.authorSaxena, R
dc.contributor.authorSchaffner, SF
dc.contributor.authorVarilly, P
dc.contributor.authorLi, C
dc.contributor.authorStein, LD
dc.contributor.authorKrishnan, L
dc.contributor.authorSmith, AV
dc.contributor.authorThorisson, GA
dc.contributor.authorBirren, BW
dc.contributor.authorChakravarti, A
dc.contributor.authorChen, PE
dc.contributor.authorCutler, DJ
dc.contributor.authorKashuk, CS
dc.contributor.authorLin, S
dc.contributor.authorAbecasis, GR
dc.contributor.authorLin, W
dc.contributor.authorGuan, W
dc.contributor.authorMunro, HM
dc.contributor.authorQin, ZS
dc.contributor.authorDaly, MJ
dc.contributor.authorThomas, DJ
dc.contributor.authorMcVean, G
dc.contributor.authorBottolo, L
dc.contributor.authorEyheramendy, S
dc.contributor.authorFreeman, C
dc.contributor.authorMarchini, J
dc.contributor.authorMyers, S
dc.contributor.authorLiu, S
dc.contributor.authorSpencer, C
dc.contributor.authorStephens, M
dc.contributor.authorWilson, RK
dc.contributor.authorDonnelly, P
dc.contributor.authorCardon, LR
dc.contributor.authorClarke, G
dc.contributor.authorEvans, DM
dc.contributor.authorMorris, AP
dc.contributor.authorWeir, BS
dc.contributor.authorTsunoda, T
dc.contributor.authorMullikin, JC
dc.contributor.authorPan, H
dc.contributor.authorSherry, ST
dc.contributor.authorYu, J
dc.contributor.authorFeolo, M
dc.contributor.authorZhang, H
dc.contributor.authorZeng, C
dc.contributor.authorZhao, H
dc.contributor.authorMatsuda, I
dc.contributor.authorFukushima, Y
dc.contributor.authorMacer, DR
dc.contributor.authorSuda, E
dc.contributor.authorRotimi, CN
dc.contributor.authorTang, X
dc.contributor.authorGwilliam, R
dc.contributor.authorAdebamowo, CA
dc.contributor.authorAjayi, I
dc.contributor.authorAniagwu, T
dc.contributor.authorMarshall, PA
dc.contributor.authorNkwodimmah, C
dc.contributor.authorRoyal, CDM
dc.contributor.authorLeppert, MF
dc.contributor.authorDixon, M
dc.contributor.authorPeiffer, A
dc.contributor.authorQiu, R
dc.contributor.authorFulton, LL
dc.contributor.authorWang, J
dc.contributor.authorKent, A
dc.contributor.authorKato, K
dc.contributor.authorNiikawa, N
dc.contributor.authorAdewole, IF
dc.contributor.authorKnoppers, BM
dc.contributor.authorFoster, MW
dc.contributor.authorClayton, EW
dc.contributor.authorWatkin, J
dc.contributor.authorGibbs, RA
dc.contributor.authorRogers, J
dc.contributor.authorMuzny, D
dc.contributor.authorWang, W
dc.contributor.authorNazareth, L
dc.contributor.authorBurton, J
dc.contributor.authorCarter, NP
dc.contributor.authorClee, CM
dc.contributor.authorGriffiths, M
dc.contributor.authorJones, MC
dc.contributor.authorMcLay, K
dc.contributor.authorPlumb, RW
dc.contributor.authorRoss, MT
dc.contributor.authorHunt, S
dc.contributor.authorZhang, B
dc.contributor.authorSims, SK
dc.contributor.authorWilley, DL
dc.contributor.authorChen, Z
dc.contributor.authorHan, H
dc.contributor.authorKang, L
dc.contributor.authorGodbout, M
dc.contributor.authorWallenburg, JC
dc.contributor.authorL'Archevêque, P
dc.contributor.authorBellemare, G
dc.contributor.authorMorrison, J
dc.contributor.authorSaeki, K
dc.contributor.authorZhang, Q
dc.contributor.authorWang, H
dc.contributor.authorAn, D
dc.contributor.authorFu, H
dc.contributor.authorLi, Q
dc.contributor.authorWang, Z
dc.contributor.authorWang, R
dc.contributor.authorHolden, AL
dc.contributor.authorBrooks, LD
dc.contributor.authorPowell, D
dc.contributor.authorMcEwen, JE
dc.contributor.authorBird, CR
dc.contributor.authorZhao, H
dc.contributor.authorGuyer, MS
dc.contributor.authorNailer, PJ
dc.contributor.authorWang, VO
dc.contributor.authorPeterson, JL
dc.contributor.authorShi, M
dc.contributor.authorSpiegel, J
dc.contributor.authorSung, LM
dc.contributor.authorStranger, BE
dc.contributor.authorWitonsky, J
dc.contributor.authorZacharia, LF
dc.contributor.authorCollins, FS
dc.contributor.authorZhou, J
dc.contributor.authorKennedy, K
dc.contributor.authorJamieson, R
dc.contributor.authorStewart, J
dc.contributor.authorBarry, R
dc.contributor.authorBlumenstiel, B
dc.contributor.authorCamargo, A
dc.contributor.authorWhittaker, P
dc.contributor.authorDefelice, M
dc.contributor.authorFaggart, M
dc.contributor.authorGoyette, M
dc.contributor.authorGupta, S
dc.contributor.authorMoore, J
dc.contributor.authorNguyen, H
dc.contributor.authorParkin, M
dc.contributor.authorRoy, J
dc.contributor.authorStahl, E
dc.contributor.authorWinchester, E
dc.contributor.authorBentley, DR
dc.contributor.authorAltshuler, D
dc.contributor.authorShen, Y
dc.contributor.authorYao, Z
dc.contributor.authorHuang, W
dc.contributor.authorChu, X
dc.contributor.authorHe, Y
dc.contributor.authorJin, L
dc.contributor.authorLiu, Y
dc.contributor.authorShen, Y
dc.contributor.authorSun, W
dc.contributor.authorDe Bakker, PIW
dc.contributor.authorWang, H
dc.date.accessioned2010-09-06T08:18:10Z
dc.date.available2010-09-06T08:18:10Z
dc.date.issued2005
dc.description.abstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationNature, 2005, v. 437 n. 7063, p. 1299-1320 [How to Cite?]
DOI: http://dx.doi.org/10.1038/nature04226
dc.identifier.citeulike366486
dc.identifier.doihttp://dx.doi.org/10.1038/nature04226
dc.identifier.epage1320
dc.identifier.hkuros110731
dc.identifier.isiWOS:000232829100044
dc.identifier.issn0028-0836
2011 Impact Factor: 36.28
2011 SCImago Journal Rankings: 7.767
dc.identifier.issue7063
dc.identifier.openurl
dc.identifier.pmcidPMC1880871
dc.identifier.pmid16255080
dc.identifier.scopuseid_2-s2.0-79959524146
dc.identifier.spage1299
dc.identifier.urihttp://hdl.handle.net/10722/81471
dc.identifier.volume437
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
dc.publisher.placeUnited Kingdom
dc.relation.ispartofNature
dc.relation.referencesReferences in Scopus
dc.subject.meshChromosomes, Human, Y - genetics
dc.subject.meshDNA, Mitochondrial - genetics
dc.subject.meshGenome, Human
dc.subject.meshHaplotypes - genetics
dc.subject.meshPolymorphism, Single Nucleotide - genetics
dc.titleA haplotype map of the human genome
dc.typeArticle
Author Affiliations
  1. Scientific and Cultural Organization Bangkok
  2. Massachusetts General Hospital
  3. University of California, San Francisco
  4. Beijing Normal University
  5. Baylor College of Medicine
  6. Chinese Academy of Social Sciences
  7. Cold Spring Harbor Laboratory
  8. National Human Genome Research Institute
  9. Wellcome Trust
  10. University of Tsukuba
  11. Japan Ministry of Education, Culture, Sports, Science and Technology
  12. University of Oklahoma
  13. Human Genetic Resource Administration of China
  14. Perlegen Sciences, Inc.
  15. Solexa Ltd.
  16. Nagasaki University
  17. Chinese National Human Genome Center at Shanghai
  18. The University of Hong Kong
  19. SNP Consortium
  20. University of Ibadan
  21. Howard University
  22. Wellcome Trust Sanger Institute
  23. Riken
  24. North Carolina State University
  25. Wellcome Trust Centre for Human Genetics
  26. null
  27. null
  28. University of Maryland, Baltimore
  29. Washington University in St. Louis School of Medicine
  30. Institute of Medical Science The University of Tokyo
  31. Chinese Academy of Sciences
  32. National Center for Biotechnology Information
  33. Health Sciences University of Hokkaido
  34. Novartis Pharma
  35. Genetic Interest Group
  36. ParAllele BioScience
  37. University of Michigan School of Public Health
  38. Kyoto University
  39. Case Western Reserve University
  40. null
  41. Hong Kong University of Science and Technology
  42. University of Oxford
  43. University of Utah Health Sciences Center
  44. University of California, Santa Cruz
  45. University of Washington Seattle
  46. Shinshu University Faculty of Medicine
  47. The Johns Hopkins School of Medicine
  48. Illumina, Inc.
  49. Vanderbilt University
  50. Broad Institute
  51. Université de Montréal
  52. Frost & Sullivan
  53. Chinese University of Hong Kong
  54. National Institutes of Health, Bethesda
  55. McGill University
  56. Basic Research Service of the Ministry of Science and Technology of the P. R. China