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Conference Paper: Grey matter excess in basal ganglia after early treatment in neuroleptic naïve, newly diagnosed schizophrenia

TitleGrey matter excess in basal ganglia after early treatment in neuroleptic naïve, newly diagnosed schizophrenia
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Montreux, Switzerland, 3-7 February 2008. In Schizophrenia Research, 2008, v. 98 suppl., p. 128-129 How to Cite?
AbstractBackground: Basalganglia volumetric increases have been reported in schizophrenic patients afterearly weeks of neuroleptictreatment. To validate the early effect of neuroleptics on brain plasticity, we explored the bilateral caudate nucleus volumetric differences in a prospective, longitudinal, cohort of anti-psychotic naïve individuals newlydiagnosed with schizophrenia. Methods: 14 patients (6 males, 8 females) had MRI brain scans before, and after 3 weeks of antipsychotic treatment. 128 slices, contiguous, 1.2 mm thick T1 scans were used for manual (region of interest) tracing. Caudate nucleus volumes were measured “blind” to the time of the scan using MEASURE software. All measurements were performed by two raters and the inter-rater reliability between the two raters was 0.95 using left and right caudate nuclei on 10 scans. To reduce inter-rater variance, results from one rater measuring all of the MRI scans was reported. The intra-class correlation coefficient (ICC) for this rater was 0.97 for 5 scans measured 3 weeks apart. Results: We found that patients treated for a mean of 3 weeks, compared to baseline, had a total caudate volume increase of 5.4% (2 tailed p < 0.001). The left caudate was increased by 3.5% (2 tailed p < 0.001) and the right caudate by 7.4% (2 tailed p < 0.002). Conclusions: This result provides evidence to confirm our preliminary voxel-based morphometric (VBM) analysis findings in this longitudinal cohort. Earlybasalganglia volumetric increase after anti-psychotic exposure suggests that drug-mediated neural plasticity occurs during clinical recovery.
Persistent Identifierhttp://hdl.handle.net/10722/81467
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorMerali, HSen_HK
dc.contributor.authorDeng, MYen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-09-06T08:18:07Z-
dc.date.available2010-09-06T08:18:07Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Montreux, Switzerland, 3-7 February 2008. In Schizophrenia Research, 2008, v. 98 suppl., p. 128-129en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81467-
dc.description.abstractBackground: Basalganglia volumetric increases have been reported in schizophrenic patients afterearly weeks of neuroleptictreatment. To validate the early effect of neuroleptics on brain plasticity, we explored the bilateral caudate nucleus volumetric differences in a prospective, longitudinal, cohort of anti-psychotic naïve individuals newlydiagnosed with schizophrenia. Methods: 14 patients (6 males, 8 females) had MRI brain scans before, and after 3 weeks of antipsychotic treatment. 128 slices, contiguous, 1.2 mm thick T1 scans were used for manual (region of interest) tracing. Caudate nucleus volumes were measured “blind” to the time of the scan using MEASURE software. All measurements were performed by two raters and the inter-rater reliability between the two raters was 0.95 using left and right caudate nuclei on 10 scans. To reduce inter-rater variance, results from one rater measuring all of the MRI scans was reported. The intra-class correlation coefficient (ICC) for this rater was 0.97 for 5 scans measured 3 weeks apart. Results: We found that patients treated for a mean of 3 weeks, compared to baseline, had a total caudate volume increase of 5.4% (2 tailed p < 0.001). The left caudate was increased by 3.5% (2 tailed p < 0.001) and the right caudate by 7.4% (2 tailed p < 0.002). Conclusions: This result provides evidence to confirm our preliminary voxel-based morphometric (VBM) analysis findings in this longitudinal cohort. Earlybasalganglia volumetric increase after anti-psychotic exposure suggests that drug-mediated neural plasticity occurs during clinical recovery.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.titleGrey matter excess in basal ganglia after early treatment in neuroleptic naïve, newly diagnosed schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailDeng, MY: michdeng@hkusua.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailCheung, V: cheungv@graduate.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.doi10.1016/j.schres.2007.12.298-
dc.identifier.hkuros142202en_HK
dc.identifier.hkuros143577-
dc.identifier.volume98-
dc.identifier.issuesuppl.-
dc.identifier.spage128-
dc.identifier.epage129-

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