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Article: WHAP: Haplotype-based association analysis

TitleWHAP: Haplotype-based association analysis
Authors
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/
Citation
Bioinformatics, 2007, v. 23 n. 2, p. 255-256 How to Cite?
AbstractSummary: We describe a software tool to perform haplotype-based association analysis, for quantitative and qualitative traits, in population and family samples, using single nucleotide polymorphism or multiallelic marker data. A range of tests is offered: omnibus and haplotype-specific tests; prospective and retrospective likelihoods; covariates and moderators; sliding window analyses; permutation P-values. We focus on the ability to flexibly impose constraints on haplotype effects, which allows for a range of conditional haplotype-based likelihood ratio tests: for example, whether an allele has an effect independent of its haplotypic background, or whether a single variant can explain the overall association at a locus. We illustrate using these tests to dissect a multi-locus association. © 2007 Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/81464
ISSN
2014 Impact Factor: 4.981
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPurcell, Sen_HK
dc.contributor.authorDaly, MJen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2010-09-06T08:18:04Z-
dc.date.available2010-09-06T08:18:04Z-
dc.date.issued2007en_HK
dc.identifier.citationBioinformatics, 2007, v. 23 n. 2, p. 255-256en_HK
dc.identifier.issn1367-4803en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81464-
dc.description.abstractSummary: We describe a software tool to perform haplotype-based association analysis, for quantitative and qualitative traits, in population and family samples, using single nucleotide polymorphism or multiallelic marker data. A range of tests is offered: omnibus and haplotype-specific tests; prospective and retrospective likelihoods; covariates and moderators; sliding window analyses; permutation P-values. We focus on the ability to flexibly impose constraints on haplotype effects, which allows for a range of conditional haplotype-based likelihood ratio tests: for example, whether an allele has an effect independent of its haplotypic background, or whether a single variant can explain the overall association at a locus. We illustrate using these tests to dissect a multi-locus association. © 2007 Oxford University Press.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/en_HK
dc.relation.ispartofBioinformaticsen_HK
dc.rightsBioinformatics. Copyright © Oxford University Press.en_HK
dc.titleWHAP: Haplotype-based association analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1367-4803&volume=23&issue=2&spage=255&epage=256&date=2007&atitle=Haplotype-based+association+analysisen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/bioinformatics/btl580en_HK
dc.identifier.pmid17118959en_HK
dc.identifier.scopuseid_2-s2.0-33846653970en_HK
dc.identifier.hkuros133104en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846653970&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue2en_HK
dc.identifier.spage255en_HK
dc.identifier.epage256en_HK
dc.identifier.isiWOS:000243992400059-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPurcell, S=7005489464en_HK
dc.identifier.scopusauthoridDaly, MJ=7201456226en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.citeulike1068458-

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