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Article: WHAP: Haplotype-based association analysis
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TitleWHAP: Haplotype-based association analysis
 
AuthorsPurcell, S1 3
Daly, MJ1 3
Sham, PC2
 
Issue Date2007
 
PublisherOxford University Press. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/
 
CitationBioinformatics, 2007, v. 23 n. 2, p. 255-256 [How to Cite?]
DOI: http://dx.doi.org/10.1093/bioinformatics/btl580
 
AbstractSummary: We describe a software tool to perform haplotype-based association analysis, for quantitative and qualitative traits, in population and family samples, using single nucleotide polymorphism or multiallelic marker data. A range of tests is offered: omnibus and haplotype-specific tests; prospective and retrospective likelihoods; covariates and moderators; sliding window analyses; permutation P-values. We focus on the ability to flexibly impose constraints on haplotype effects, which allows for a range of conditional haplotype-based likelihood ratio tests: for example, whether an allele has an effect independent of its haplotypic background, or whether a single variant can explain the overall association at a locus. We illustrate using these tests to dissect a multi-locus association. © 2007 Oxford University Press.
 
ISSN1367-4803
2013 Impact Factor: 4.621
 
DOIhttp://dx.doi.org/10.1093/bioinformatics/btl580
 
ISI Accession Number IDWOS:000243992400059
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorPurcell, S
 
dc.contributor.authorDaly, MJ
 
dc.contributor.authorSham, PC
 
dc.date.accessioned2010-09-06T08:18:04Z
 
dc.date.available2010-09-06T08:18:04Z
 
dc.date.issued2007
 
dc.description.abstractSummary: We describe a software tool to perform haplotype-based association analysis, for quantitative and qualitative traits, in population and family samples, using single nucleotide polymorphism or multiallelic marker data. A range of tests is offered: omnibus and haplotype-specific tests; prospective and retrospective likelihoods; covariates and moderators; sliding window analyses; permutation P-values. We focus on the ability to flexibly impose constraints on haplotype effects, which allows for a range of conditional haplotype-based likelihood ratio tests: for example, whether an allele has an effect independent of its haplotypic background, or whether a single variant can explain the overall association at a locus. We illustrate using these tests to dissect a multi-locus association. © 2007 Oxford University Press.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationBioinformatics, 2007, v. 23 n. 2, p. 255-256 [How to Cite?]
DOI: http://dx.doi.org/10.1093/bioinformatics/btl580
 
dc.identifier.citeulike1068458
 
dc.identifier.doihttp://dx.doi.org/10.1093/bioinformatics/btl580
 
dc.identifier.epage256
 
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dc.identifier.isiWOS:000243992400059
 
dc.identifier.issn1367-4803
2013 Impact Factor: 4.621
 
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dc.identifier.openurl
 
dc.identifier.pmid17118959
 
dc.identifier.scopuseid_2-s2.0-33846653970
 
dc.identifier.spage255
 
dc.identifier.urihttp://hdl.handle.net/10722/81464
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBioinformatics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsBioinformatics. Copyright © Oxford University Press.
 
dc.titleWHAP: Haplotype-based association analysis
 
dc.typeArticle
 
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Author Affiliations
  1. Massachusetts General Hospital
  2. The University of Hong Kong
  3. Broad Institute