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Article: No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients

TitleNo association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients
Authors
KeywordsFrontal lobe dysfunction
Genetics
Neurocognitive deficit
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2001, v. 105 n. 3, p. 175-185 How to Cite?
AbstractSerotonin dysfunction has been implicated in the pathogenesis of schizophrenia. Previous studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. One possible explanation for such discrepancy is disease heterogeneity due to the current limitations in the diagnosis of schizophrenia. We conducted a case-control study of the T102C polymorphism with detailed characterisation of the clinical phenotypes to investigate the possible association with schizophrenia not only at the diagnostic level, but also with reference to other clinical phenotypes potentially related to serotonin dysfunction. Four hundred and seventy-one biologically unrelated schizophrenic patients and 523 unrelated healthy controls of Han Chinese descent in Hong Kong were compared for genotypes and allele frequencies of the T102C polymorphism by PCR amplification and restriction analysis. No evidence of association was detected at the diagnostic level and various clinical phenotypes. However, we found a trend association with small effect size between genotype 102T/102C and patients with better verbal fluency and less motor co-ordination soft neurological signs. There is a need for future large-scale studies on the possible associations between genetic polymorphisms and neurocognitive function impairments in schizophrenia. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81463
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuk Lun Chen, Ren_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorYu Hai Chen, Een_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorFuk Chi Cheung, Een_HK
dc.contributor.authorChok King Hui, Ten_HK
dc.contributor.authorLan Kwok, Cen_HK
dc.contributor.authorLiehMak, Fen_HK
dc.contributor.authorHua Zhao, Jen_HK
dc.contributor.authorCollier, Den_HK
dc.contributor.authorMurray, Ren_HK
dc.date.accessioned2010-09-06T08:18:04Z-
dc.date.available2010-09-06T08:18:04Z-
dc.date.issued2001en_HK
dc.identifier.citationPsychiatry Research, 2001, v. 105 n. 3, p. 175-185en_HK
dc.identifier.issn0165-1781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81463-
dc.description.abstractSerotonin dysfunction has been implicated in the pathogenesis of schizophrenia. Previous studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. One possible explanation for such discrepancy is disease heterogeneity due to the current limitations in the diagnosis of schizophrenia. We conducted a case-control study of the T102C polymorphism with detailed characterisation of the clinical phenotypes to investigate the possible association with schizophrenia not only at the diagnostic level, but also with reference to other clinical phenotypes potentially related to serotonin dysfunction. Four hundred and seventy-one biologically unrelated schizophrenic patients and 523 unrelated healthy controls of Han Chinese descent in Hong Kong were compared for genotypes and allele frequencies of the T102C polymorphism by PCR amplification and restriction analysis. No evidence of association was detected at the diagnostic level and various clinical phenotypes. However, we found a trend association with small effect size between genotype 102T/102C and patients with better verbal fluency and less motor co-ordination soft neurological signs. There is a need for future large-scale studies on the possible associations between genetic polymorphisms and neurocognitive function impairments in schizophrenia. © 2001 Elsevier Science Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_HK
dc.relation.ispartofPsychiatry Researchen_HK
dc.rightsPsychiatry Research. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectFrontal lobe dysfunctionen_HK
dc.subjectGeneticsen_HK
dc.subjectNeurocognitive deficiten_HK
dc.titleNo association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-1781&volume=105&spage=175&epage=185&date=2001&atitle=No+association+between+T102C+polymorphism+of+serotonin-2A+receptor+gene+and+clinical+phenotypes+of+Chinese+schizophrenic+patientsen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailYu Hai Chen, E: eyhchen@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityYu Hai Chen, E=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-1781(01)00343-2en_HK
dc.identifier.pmid11814537-
dc.identifier.scopuseid_2-s2.0-0035981177en_HK
dc.identifier.hkuros73008en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035981177&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue3en_HK
dc.identifier.spage175en_HK
dc.identifier.epage185en_HK
dc.identifier.isiWOS:000173825700003-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridYuk Lun Chen, R=15768531800en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridYu Hai Chen, E=7402315729en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridFuk Chi Cheung, E=15767392900en_HK
dc.identifier.scopusauthoridChok King Hui, T=15766972800en_HK
dc.identifier.scopusauthoridLan Kwok, C=15767595700en_HK
dc.identifier.scopusauthoridLiehMak, F=6603893598en_HK
dc.identifier.scopusauthoridHua Zhao, J=36458528100en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK

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