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Article: Pontine cholinergic respiratory depression in neonatal and young rats

TitlePontine cholinergic respiratory depression in neonatal and young rats
Authors
KeywordsCarbachol
Neonatal rat
Pontine reticular formation
REM sleep
Respiration
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1998, v. 62 n. 24, p. 2249-2256 How to Cite?
AbstractWe postulated that activation of pontine cholinergic mechanisms would cause respiratory depression in neonatal and young rats. Phrenic activity was recorded in decerebrate, paralyzed, ventilated and vagotomized rats of 4 to 22 days after birth. Small volumes (10-60 nl) of carbachol (44-88 mM) were injected into the medial portion of the rostral pons. The injection of carbachol, but not saline, decreased phrenic peak activity (83 ± 6% of control) and respiratory frequency (64 ± 9.5% of control) within 2 min following the injection in neonates and the depression lasted for less than 10 min. The site of injection in the pontine reticular formation was confirmed by histology. Results suggest that cholinergic mechanisms in the medial pons depress respiratory activity in the neonate.
Persistent Identifierhttp://hdl.handle.net/10722/81358
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_HK
dc.contributor.authorStJohn, WMen_HK
dc.date.accessioned2010-09-06T08:16:43Z-
dc.date.available2010-09-06T08:16:43Z-
dc.date.issued1998en_HK
dc.identifier.citationLife Sciences, 1998, v. 62 n. 24, p. 2249-2256en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81358-
dc.description.abstractWe postulated that activation of pontine cholinergic mechanisms would cause respiratory depression in neonatal and young rats. Phrenic activity was recorded in decerebrate, paralyzed, ventilated and vagotomized rats of 4 to 22 days after birth. Small volumes (10-60 nl) of carbachol (44-88 mM) were injected into the medial portion of the rostral pons. The injection of carbachol, but not saline, decreased phrenic peak activity (83 ± 6% of control) and respiratory frequency (64 ± 9.5% of control) within 2 min following the injection in neonates and the depression lasted for less than 10 min. The site of injection in the pontine reticular formation was confirmed by histology. Results suggest that cholinergic mechanisms in the medial pons depress respiratory activity in the neonate.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectCarbacholen_HK
dc.subjectNeonatal raten_HK
dc.subjectPontine reticular formationen_HK
dc.subjectREM sleepen_HK
dc.subjectRespirationen_HK
dc.titlePontine cholinergic respiratory depression in neonatal and young ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=62&issue=24&spage=2249&epage=2256&date=1997&atitle=Pontine+cholinergic+respiratory+depression+in+neonatal+and+young+ratsen_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(98)00203-3en_HK
dc.identifier.pmid9627084-
dc.identifier.scopuseid_2-s2.0-0032496247en_HK
dc.identifier.hkuros44032en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032496247&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue24en_HK
dc.identifier.spage2249en_HK
dc.identifier.epage2256en_HK
dc.identifier.isiWOS:000073630600011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFung, ML=7101955092en_HK
dc.identifier.scopusauthoridStJohn, WM=36831054200en_HK

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