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Article: Neuroendocrinology of melatonin in reproduction: Recent developments

TitleNeuroendocrinology of melatonin in reproduction: Recent developments
Authors
KeywordsEpididymis
Hypothalamus
Mammary gland
Melatonin receptors
Ovary
Pituitary
Prostate
Rhythm
Testis
Vas deferens
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jchemneu
Citation
Journal Of Chemical Neuroanatomy, 1998, v. 14 n. 3-4, p. 157-166 How to Cite?
AbstractThe circadian melatonin rhythm with high levels in the dark period is important for the synchronization of reproductive response to appropriate environmental conditions in animals. The target sites of melatonin action on reproductive functions remain to be clarified. Using autoradiography (ARG) and radioreceptor binding assays with 2[ 125I]iodomelatonin, a melatonin agonist, as the radioligand, studies on the sites of melatonin action have increased significantly in the last ten years. The recent cloning of melatonin receptor subtypes also allowed the characterization of receptor(s) to the molecular level. Earlier reports have documented that the hypothalamic-pituitary axis plays a vital role in the regulation of reproduction by melatonin. This is supported in part by the demonstration of melatonin receptors in the suprachiasmatic nuclei (SCN) in the brain and pars tuberalis (PT) in the pituitary. However, the nature of SCN and PT involvement in the reproductive action of melatonin remains unknown. In addition to the hypothalamus and pituitary, the two classical sites of melatonin action, other targets have been identified. The recent demonstration of 2[ 125I]iodomelatonin binding sites or melatonin receptors in the testis, epididymis, vas deferens, prostate, ovary and mammary gland suggest the concept of multiple sites of melatonin action on the reproductive system. The presence of melatonin receptors in the said tissues is consistent with earlier reports of direct melatonin actions on different levels of the reproductive system. This multiple levels of melatonin action, from the hypothalamus, pituitary, gonads to other reproductive tissues form a robust system of photoperiodic control in animal reproduction. This would guarantee successful gestation and delivery of the offspring at a time with optimum food availability and ultimately favourable for the survival of species. Molecular and cellular studies of melatonin signaling system(s), its regulation and effects on downstream functional events in the future may provide new insights and directions for the study of the physiology and pharmacology of fertility and contraception in animals and humans.
Persistent Identifierhttp://hdl.handle.net/10722/81356
ISSN
2015 Impact Factor: 1.8
2015 SCImago Journal Rankings: 0.908
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPang, SFen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorAyre, EAen_HK
dc.contributor.authorPang, CSen_HK
dc.contributor.authorLee, PPNen_HK
dc.contributor.authorXu, RKen_HK
dc.contributor.authorChow, PHen_HK
dc.contributor.authorYu, ZHen_HK
dc.contributor.authorShiu, SYWen_HK
dc.date.accessioned2010-09-06T08:16:42Z-
dc.date.available2010-09-06T08:16:42Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Chemical Neuroanatomy, 1998, v. 14 n. 3-4, p. 157-166en_HK
dc.identifier.issn0891-0618en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81356-
dc.description.abstractThe circadian melatonin rhythm with high levels in the dark period is important for the synchronization of reproductive response to appropriate environmental conditions in animals. The target sites of melatonin action on reproductive functions remain to be clarified. Using autoradiography (ARG) and radioreceptor binding assays with 2[ 125I]iodomelatonin, a melatonin agonist, as the radioligand, studies on the sites of melatonin action have increased significantly in the last ten years. The recent cloning of melatonin receptor subtypes also allowed the characterization of receptor(s) to the molecular level. Earlier reports have documented that the hypothalamic-pituitary axis plays a vital role in the regulation of reproduction by melatonin. This is supported in part by the demonstration of melatonin receptors in the suprachiasmatic nuclei (SCN) in the brain and pars tuberalis (PT) in the pituitary. However, the nature of SCN and PT involvement in the reproductive action of melatonin remains unknown. In addition to the hypothalamus and pituitary, the two classical sites of melatonin action, other targets have been identified. The recent demonstration of 2[ 125I]iodomelatonin binding sites or melatonin receptors in the testis, epididymis, vas deferens, prostate, ovary and mammary gland suggest the concept of multiple sites of melatonin action on the reproductive system. The presence of melatonin receptors in the said tissues is consistent with earlier reports of direct melatonin actions on different levels of the reproductive system. This multiple levels of melatonin action, from the hypothalamus, pituitary, gonads to other reproductive tissues form a robust system of photoperiodic control in animal reproduction. This would guarantee successful gestation and delivery of the offspring at a time with optimum food availability and ultimately favourable for the survival of species. Molecular and cellular studies of melatonin signaling system(s), its regulation and effects on downstream functional events in the future may provide new insights and directions for the study of the physiology and pharmacology of fertility and contraception in animals and humans.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jchemneuen_HK
dc.relation.ispartofJournal of Chemical Neuroanatomyen_HK
dc.rightsJournal of Chemical Neuroanatomy. Copyright © Elsevier BV.en_HK
dc.subjectEpididymisen_HK
dc.subjectHypothalamusen_HK
dc.subjectMammary glanden_HK
dc.subjectMelatonin receptorsen_HK
dc.subjectOvaryen_HK
dc.subjectPituitaryen_HK
dc.subjectProstateen_HK
dc.subjectRhythmen_HK
dc.subjectTestisen_HK
dc.subjectVas deferensen_HK
dc.titleNeuroendocrinology of melatonin in reproduction: Recent developmentsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0891-0618&volume=14&spage=157&epage=166&date=1998&atitle=Neuroendocrinology+of+melatonin+in+reproduction:+recent+developmentsen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0891-0618(98)00029-5en_HK
dc.identifier.pmid9704894-
dc.identifier.scopuseid_2-s2.0-0032104553en_HK
dc.identifier.hkuros37914en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032104553&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue3-4en_HK
dc.identifier.spage157en_HK
dc.identifier.epage166en_HK
dc.identifier.isiWOS:000075419000006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.scopusauthoridLi, L=36985957600en_HK
dc.identifier.scopusauthoridAyre, EA=6602272700en_HK
dc.identifier.scopusauthoridPang, CS=7201425191en_HK
dc.identifier.scopusauthoridLee, PPN=7406119629en_HK
dc.identifier.scopusauthoridXu, RK=7402814204en_HK
dc.identifier.scopusauthoridChow, PH=7202656919en_HK
dc.identifier.scopusauthoridYu, ZH=7404347160en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK

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