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Article: Acetylcholine induces contractile and relaxant effects in canine nasal venous systems

TitleAcetylcholine induces contractile and relaxant effects in canine nasal venous systems
Authors
KeywordsAcetylcholine
Nasal venous vessels
Nitric oxide
Vasocontraction
Vasorelaxation
Issue Date2006
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2006, v. 28 n. 4, p. 839-846 How to Cite?
AbstractAcetylcholine (ACh) induces nasal congestion at low doses but decongestion at high doses.The current study investigated the vascular mechanisms underlying this biphasic nasal airway response in dogs. Collecting and outflow veins from anterior and posterior nasal venous systems and the septal mucosa (containing sinusoidal venous plexuses) were isolated. The in vitro isometric tension of the vascular segments was monitored to reflect vascular reactivity. Immunohistochemical localisation of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase and endothelial nitric oxide synthase (eNOS) was performed. ACh did not affect the venous plexuses but contracted the anterior collecting vein and the outflow veins of both systems in a concentration-dependent manner; the responses were unaffected by nitro-L-arginine-methyl-ester (L-NAME). ACh relaxed posterior collecting veins at low concentrations but contracted them at higher concentrations; L-NAME enhanced the contractions but inhibited the relaxations, with the inhibition reversed by L-arginine. NADPH-diaphorase and eNOS were located predominantly in the posterior collecting veins. The fact that acetylcholine at low concentrations relaxes posterior collecting veins but contracts other collecting and outflow veins implies that the agonist in vivo may induce nasal congestion by increasing posterior blood volume. At higher concentrations, acetylcholine contracts posterior collecting veins as well, implying diminished blood volume in both venous systems, and consequently nasal decongestion. The induced contraction in posterior collecting veins is nitric oxide-independent, while the induced relaxation is nitric oxide-dependent. Copyright © ERS Journals Ltd 2006.
Persistent Identifierhttp://hdl.handle.net/10722/81351
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Nen_HK
dc.contributor.authorLung, MAen_HK
dc.date.accessioned2010-09-06T08:16:39Z-
dc.date.available2010-09-06T08:16:39Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Respiratory Journal, 2006, v. 28 n. 4, p. 839-846en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81351-
dc.description.abstractAcetylcholine (ACh) induces nasal congestion at low doses but decongestion at high doses.The current study investigated the vascular mechanisms underlying this biphasic nasal airway response in dogs. Collecting and outflow veins from anterior and posterior nasal venous systems and the septal mucosa (containing sinusoidal venous plexuses) were isolated. The in vitro isometric tension of the vascular segments was monitored to reflect vascular reactivity. Immunohistochemical localisation of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase and endothelial nitric oxide synthase (eNOS) was performed. ACh did not affect the venous plexuses but contracted the anterior collecting vein and the outflow veins of both systems in a concentration-dependent manner; the responses were unaffected by nitro-L-arginine-methyl-ester (L-NAME). ACh relaxed posterior collecting veins at low concentrations but contracted them at higher concentrations; L-NAME enhanced the contractions but inhibited the relaxations, with the inhibition reversed by L-arginine. NADPH-diaphorase and eNOS were located predominantly in the posterior collecting veins. The fact that acetylcholine at low concentrations relaxes posterior collecting veins but contracts other collecting and outflow veins implies that the agonist in vivo may induce nasal congestion by increasing posterior blood volume. At higher concentrations, acetylcholine contracts posterior collecting veins as well, implying diminished blood volume in both venous systems, and consequently nasal decongestion. The induced contraction in posterior collecting veins is nitric oxide-independent, while the induced relaxation is nitric oxide-dependent. Copyright © ERS Journals Ltd 2006.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectAcetylcholineen_HK
dc.subjectNasal venous vesselsen_HK
dc.subjectNitric oxideen_HK
dc.subjectVasocontractionen_HK
dc.subjectVasorelaxationen_HK
dc.titleAcetylcholine induces contractile and relaxant effects in canine nasal venous systemsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=28&spage=839&epage=846&date=2006&atitle=Acetylcholine+induces+contractile+and+relaxant+effects+in+canine+nasal+venous+systemsen_HK
dc.identifier.emailLung, MA: makylung@hkucc.hku.hken_HK
dc.identifier.authorityLung, MA=rp00319en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1183/09031936.06.00075905en_HK
dc.identifier.pmid16737988-
dc.identifier.scopuseid_2-s2.0-33847360981en_HK
dc.identifier.hkuros136602en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847360981&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue4en_HK
dc.identifier.spage839en_HK
dc.identifier.epage846en_HK
dc.identifier.eissn1399-3003-
dc.identifier.isiWOS:000241345000026-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridWang, N=7404341037en_HK
dc.identifier.scopusauthoridLung, MA=7006411781en_HK

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