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Article: Probing excitation-contraction coupling in trachealis smooth muscle with the mycotoxin cyclopiazonic acid

TitleProbing excitation-contraction coupling in trachealis smooth muscle with the mycotoxin cyclopiazonic acid
Authors
KeywordsAirway smooth muscle
Cyclopiazonic acid
Dihydropyridines
Excitation contraction coupling
Internal Ca2+ stores
Muscarinic stimulation
Potassium channel operator
Issue Date1996
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1996, v. 23 n. 8, p. 733-737 How to Cite?
Abstract1. Muscarinic stimulation-induced tonic contraction of airway smooth muscle is independent of membrane potential. This contraction is not sensitive to inhibition by voltage-operated Ca2+ channel blockers or by K+ channel openers. 2. Cyclopiazonic acid (CPA) inhibits Ca2+ loading of internal stores but does not affect maximal tonic contraction induced by acetylcholine (ACh) in steady state conditions. 3. After depletion of internal Ca2+ stores with CPA, ACh-induced tonic contraction becomes dependent upon values of membrane potential. The contraction is then sensitive to voltage-operated Ca2+ channel blockers and to K+ channel openers. 4. Treatment of trachealis muscle with CPA potentiates the M2-mediated component of ACh stimulation, but this potentiation is not entirely responsible for the switch in excitation-contraction (E-C) coupling, 5. It is proposed that depletion of internal Ca2+ stores with CPA and promotion of M2-stimulation can lead to a switch in E-C coupling in trachealis smooth muscle from pharmaco- to electromechanical mode, perhaps by targeting a plasma membrane K+ channel.
Persistent Identifierhttp://hdl.handle.net/10722/81340
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAmoako, Den_HK
dc.contributor.authorQian, Yen_HK
dc.contributor.authorKwan, CYen_HK
dc.contributor.authorBourreau, JPen_HK
dc.date.accessioned2010-09-06T08:16:32Z-
dc.date.available2010-09-06T08:16:32Z-
dc.date.issued1996en_HK
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1996, v. 23 n. 8, p. 733-737en_HK
dc.identifier.issn0305-1870en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81340-
dc.description.abstract1. Muscarinic stimulation-induced tonic contraction of airway smooth muscle is independent of membrane potential. This contraction is not sensitive to inhibition by voltage-operated Ca2+ channel blockers or by K+ channel openers. 2. Cyclopiazonic acid (CPA) inhibits Ca2+ loading of internal stores but does not affect maximal tonic contraction induced by acetylcholine (ACh) in steady state conditions. 3. After depletion of internal Ca2+ stores with CPA, ACh-induced tonic contraction becomes dependent upon values of membrane potential. The contraction is then sensitive to voltage-operated Ca2+ channel blockers and to K+ channel openers. 4. Treatment of trachealis muscle with CPA potentiates the M2-mediated component of ACh stimulation, but this potentiation is not entirely responsible for the switch in excitation-contraction (E-C) coupling, 5. It is proposed that depletion of internal Ca2+ stores with CPA and promotion of M2-stimulation can lead to a switch in E-C coupling in trachealis smooth muscle from pharmaco- to electromechanical mode, perhaps by targeting a plasma membrane K+ channel.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_HK
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_HK
dc.subjectAirway smooth muscleen_HK
dc.subjectCyclopiazonic aciden_HK
dc.subjectDihydropyridinesen_HK
dc.subjectExcitation contraction couplingen_HK
dc.subjectInternal Ca2+ storesen_HK
dc.subjectMuscarinic stimulationen_HK
dc.subjectPotassium channel operatoren_HK
dc.titleProbing excitation-contraction coupling in trachealis smooth muscle with the mycotoxin cyclopiazonic aciden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=23&spage=733&epage=737&date=1996&atitle=Probing+excitation-contraction+coupling+in+trachealis+smooth+muscle+with+the+mycotoxin+cyclopiazonic+acid.en_HK
dc.identifier.emailBourreau, JP: bourreau@hkucc.hku.hken_HK
dc.identifier.authorityBourreau, JP=rp00389en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8886499-
dc.identifier.scopuseid_2-s2.0-0029831286en_HK
dc.identifier.hkuros26986en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029831286&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue8en_HK
dc.identifier.spage733en_HK
dc.identifier.epage737en_HK
dc.identifier.isiWOS:A1996VE53100021-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridAmoako, D=6506704096en_HK
dc.identifier.scopusauthoridQian, Y=37019487300en_HK
dc.identifier.scopusauthoridKwan, CY=7201421224en_HK
dc.identifier.scopusauthoridBourreau, JP=7003927886en_HK

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