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- Publisher Website: 10.1111/j.1440-1681.1996.tb01768.x
- Scopus: eid_2-s2.0-0029831286
- PMID: 8886499
- WOS: WOS:A1996VE53100021
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Article: Probing excitation-contraction coupling in trachealis smooth muscle with the mycotoxin cyclopiazonic acid
Title | Probing excitation-contraction coupling in trachealis smooth muscle with the mycotoxin cyclopiazonic acid |
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Authors | |
Keywords | Airway smooth muscle Cyclopiazonic acid Dihydropyridines Excitation contraction coupling Internal Ca2+ stores Muscarinic stimulation Potassium channel operator |
Issue Date | 1996 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1996, v. 23 n. 8, p. 733-737 How to Cite? |
Abstract | 1. Muscarinic stimulation-induced tonic contraction of airway smooth muscle is independent of membrane potential. This contraction is not sensitive to inhibition by voltage-operated Ca2+ channel blockers or by K+ channel openers. 2. Cyclopiazonic acid (CPA) inhibits Ca2+ loading of internal stores but does not affect maximal tonic contraction induced by acetylcholine (ACh) in steady state conditions. 3. After depletion of internal Ca2+ stores with CPA, ACh-induced tonic contraction becomes dependent upon values of membrane potential. The contraction is then sensitive to voltage-operated Ca2+ channel blockers and to K+ channel openers. 4. Treatment of trachealis muscle with CPA potentiates the M2-mediated component of ACh stimulation, but this potentiation is not entirely responsible for the switch in excitation-contraction (E-C) coupling, 5. It is proposed that depletion of internal Ca2+ stores with CPA and promotion of M2-stimulation can lead to a switch in E-C coupling in trachealis smooth muscle from pharmaco- to electromechanical mode, perhaps by targeting a plasma membrane K+ channel. |
Persistent Identifier | http://hdl.handle.net/10722/81340 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Amoako, D | en_HK |
dc.contributor.author | Qian, Y | en_HK |
dc.contributor.author | Kwan, CY | en_HK |
dc.contributor.author | Bourreau, JP | en_HK |
dc.date.accessioned | 2010-09-06T08:16:32Z | - |
dc.date.available | 2010-09-06T08:16:32Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1996, v. 23 n. 8, p. 733-737 | en_HK |
dc.identifier.issn | 0305-1870 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/81340 | - |
dc.description.abstract | 1. Muscarinic stimulation-induced tonic contraction of airway smooth muscle is independent of membrane potential. This contraction is not sensitive to inhibition by voltage-operated Ca2+ channel blockers or by K+ channel openers. 2. Cyclopiazonic acid (CPA) inhibits Ca2+ loading of internal stores but does not affect maximal tonic contraction induced by acetylcholine (ACh) in steady state conditions. 3. After depletion of internal Ca2+ stores with CPA, ACh-induced tonic contraction becomes dependent upon values of membrane potential. The contraction is then sensitive to voltage-operated Ca2+ channel blockers and to K+ channel openers. 4. Treatment of trachealis muscle with CPA potentiates the M2-mediated component of ACh stimulation, but this potentiation is not entirely responsible for the switch in excitation-contraction (E-C) coupling, 5. It is proposed that depletion of internal Ca2+ stores with CPA and promotion of M2-stimulation can lead to a switch in E-C coupling in trachealis smooth muscle from pharmaco- to electromechanical mode, perhaps by targeting a plasma membrane K+ channel. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_HK |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_HK |
dc.subject | Airway smooth muscle | en_HK |
dc.subject | Cyclopiazonic acid | en_HK |
dc.subject | Dihydropyridines | en_HK |
dc.subject | Excitation contraction coupling | en_HK |
dc.subject | Internal Ca2+ stores | en_HK |
dc.subject | Muscarinic stimulation | en_HK |
dc.subject | Potassium channel operator | en_HK |
dc.title | Probing excitation-contraction coupling in trachealis smooth muscle with the mycotoxin cyclopiazonic acid | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=23&spage=733&epage=737&date=1996&atitle=Probing+excitation-contraction+coupling+in+trachealis+smooth+muscle+with+the+mycotoxin+cyclopiazonic+acid. | en_HK |
dc.identifier.email | Bourreau, JP: bourreau@hkucc.hku.hk | en_HK |
dc.identifier.authority | Bourreau, JP=rp00389 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1440-1681.1996.tb01768.x | - |
dc.identifier.pmid | 8886499 | - |
dc.identifier.scopus | eid_2-s2.0-0029831286 | en_HK |
dc.identifier.hkuros | 26986 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029831286&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 23 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 733 | en_HK |
dc.identifier.epage | 737 | en_HK |
dc.identifier.isi | WOS:A1996VE53100021 | - |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Amoako, D=6506704096 | en_HK |
dc.identifier.scopusauthorid | Qian, Y=37019487300 | en_HK |
dc.identifier.scopusauthorid | Kwan, CY=7201421224 | en_HK |
dc.identifier.scopusauthorid | Bourreau, JP=7003927886 | en_HK |
dc.identifier.issnl | 0305-1870 | - |