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Article: Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body

TitleRegulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body
Authors
KeywordsAngiotensin II
Captopril
Chronic hypoxia
Renin-angiotensin system
Issue Date2004
PublisherAmerican Physiological Society.
Citation
Journal Of Applied Physiology, 2004, v. 96 n. 2, p. 809-813 How to Cite?
AbstractChronic hypoxia activates a local angiotensin-generating system in the carotid body. Here, we test the hypothesis that the activity of the critical enzyme for this system, angiotensin-converting enzyme (ACE), in the carotid body is subject to regulation by a time-course hypoxia. Results from the carotid body assays showed that ACE activity was markedly increased under the hypoxic stress of 7-, 14-, 21-, and 28-day exposures. The changes in ACE activity of 7-day (15.00 vs. 30.95 × 10-5 nmol·μ g-1·min-1). 14-day (8.73 vs. 30.25 × 10 -5 nmol·μg-1·min-1), and 21-day (11.41 vs. 31.83 × 10-5 nmol·μg -1·min-1) hypoxia treatments were enhanced significantly. However, ACE activity in 28-day (13.18 vs. 24.53 × 10 -5 nmol·μg-1·min-1) hypoxia treatment was observed to increase insignificantly when compared with results in the respective control groups. Captopril inhibited all rises in ACE activity in both the control and experimental groups. Results clearly indicate an activation of the enzymatic activity of ACE, the critical enzyme for determining the conversion of angiotensin I into the physiologically active angiotensin II, by chronic hypoxia in the carotid body. An increase in the ACE activity may increase the local production of angiotensin II in the carotid body and thus its agonist action at the AT1 receptor. This may be important in the modulation of cardiopulmonary adaptation in the hypoxic ventilatory response as well as for electrolyte and water homeostasis during chronic hypoxia.
Persistent Identifierhttp://hdl.handle.net/10722/81339
ISSN
2015 Impact Factor: 3.004
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, SYen_HK
dc.contributor.authorFung, MLen_HK
dc.contributor.authorLeung, PSen_HK
dc.date.accessioned2010-09-06T08:16:31Z-
dc.date.available2010-09-06T08:16:31Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Applied Physiology, 2004, v. 96 n. 2, p. 809-813en_HK
dc.identifier.issn8750-7587en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81339-
dc.description.abstractChronic hypoxia activates a local angiotensin-generating system in the carotid body. Here, we test the hypothesis that the activity of the critical enzyme for this system, angiotensin-converting enzyme (ACE), in the carotid body is subject to regulation by a time-course hypoxia. Results from the carotid body assays showed that ACE activity was markedly increased under the hypoxic stress of 7-, 14-, 21-, and 28-day exposures. The changes in ACE activity of 7-day (15.00 vs. 30.95 × 10-5 nmol·μ g-1·min-1). 14-day (8.73 vs. 30.25 × 10 -5 nmol·μg-1·min-1), and 21-day (11.41 vs. 31.83 × 10-5 nmol·μg -1·min-1) hypoxia treatments were enhanced significantly. However, ACE activity in 28-day (13.18 vs. 24.53 × 10 -5 nmol·μg-1·min-1) hypoxia treatment was observed to increase insignificantly when compared with results in the respective control groups. Captopril inhibited all rises in ACE activity in both the control and experimental groups. Results clearly indicate an activation of the enzymatic activity of ACE, the critical enzyme for determining the conversion of angiotensin I into the physiologically active angiotensin II, by chronic hypoxia in the carotid body. An increase in the ACE activity may increase the local production of angiotensin II in the carotid body and thus its agonist action at the AT1 receptor. This may be important in the modulation of cardiopulmonary adaptation in the hypoxic ventilatory response as well as for electrolyte and water homeostasis during chronic hypoxia.en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Society.en_HK
dc.relation.ispartofJournal of Applied Physiologyen_HK
dc.subjectAngiotensin IIen_HK
dc.subjectCaptoprilen_HK
dc.subjectChronic hypoxiaen_HK
dc.subjectRenin-angiotensin systemen_HK
dc.titleRegulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid bodyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=8750-7587&volume=96&issue=2&spage=809&epage=813&date=2004&atitle=Regulation+of+the+angiotensin-converting+enzyme+activity+by+a+time-course+hypoxia+in+the+carotid+bodyen_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/japplphysiol.00684.2003en_HK
dc.identifier.pmid14527966en_HK
dc.identifier.scopuseid_2-s2.0-0942276798en_HK
dc.identifier.hkuros88099en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0942276798&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume96en_HK
dc.identifier.issue2en_HK
dc.identifier.spage809en_HK
dc.identifier.epage813en_HK
dc.identifier.isiWOS:000187888400055-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, SY=7402279518en_HK
dc.identifier.scopusauthoridFung, ML=7101955092en_HK
dc.identifier.scopusauthoridLeung, PS=7401748938en_HK

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