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Article: Elevation of arterial potassium during acute systemic hypoxia is abolished by alkalosis

TitleElevation of arterial potassium during acute systemic hypoxia is abolished by alkalosis
Authors
Issue Date2002
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCS
Citation
Journal Of Cardiac Surgery, 2002, v. 17 n. 4, p. 342-346 How to Cite?
AbstractBackground: Small elevations in plasma potassium evoke vasodilation in the peripheral circulation. Systemic hypoxia elevates arterial potassium and also modifies arterial pH. Aims: We examined the interaction between pH and potassium in blood during systemic hypoxia and the effect of pH on the uptake/release of potassium in the peripheral tissues. Methods: Anesthetized dogs were ventilated with air plus oxygen for normoxia or air plus nitrogen for hypoxia. Some animals received intravenous sodium bicarbonate to elevate pH by 0.1 units. Arterial plasma potassium concentration was measured in normoxia and hypoxia. A rat gracilis muscle was perfused with normoxic Krebs buffer and the potassium content of the venous outflow was compared during perfusion at pH 7.4, 6.8, or 7.8. Results: In dogs with an arterial pH of 7.40-7.45, systemic hypoxia elevated the arterial potassium by 1 mmol/L. An arterial pH of 7.55 did not alter the basal potassium concentration, but it abolished the hypoxia-induced increase. In rat muscle, reduction of the perfusate pH from 7.4 to 6.8 reduced arterial perfusion pressure from 8.73 to 7.32 kPa and venous potassium from 6.6 to 5.2 mM. Elevation of perfusate pH to 7.8 decreased the arterial perfusion pressure from 8.44 to 6.95 kPa but did not affect venous potassium. Conclusions: The hypoxia-induced elevation of arterial potassium is abolished by increasing the pH to 7.55. This is not due to enhanced potassium uptake into peripheral tissues at high pH. Red blood cells are suggested as the most likely source of the potassium released in hypoxia.
Persistent Identifierhttp://hdl.handle.net/10722/81330
ISSN
2015 Impact Factor: 0.783
2015 SCImago Journal Rankings: 0.578
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMo, FFMen_HK
dc.contributor.authorEssackjee, HCen_HK
dc.contributor.authorBallard, HJen_HK
dc.date.accessioned2010-09-06T08:16:25Z-
dc.date.available2010-09-06T08:16:25Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Cardiac Surgery, 2002, v. 17 n. 4, p. 342-346en_HK
dc.identifier.issn0886-0440en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81330-
dc.description.abstractBackground: Small elevations in plasma potassium evoke vasodilation in the peripheral circulation. Systemic hypoxia elevates arterial potassium and also modifies arterial pH. Aims: We examined the interaction between pH and potassium in blood during systemic hypoxia and the effect of pH on the uptake/release of potassium in the peripheral tissues. Methods: Anesthetized dogs were ventilated with air plus oxygen for normoxia or air plus nitrogen for hypoxia. Some animals received intravenous sodium bicarbonate to elevate pH by 0.1 units. Arterial plasma potassium concentration was measured in normoxia and hypoxia. A rat gracilis muscle was perfused with normoxic Krebs buffer and the potassium content of the venous outflow was compared during perfusion at pH 7.4, 6.8, or 7.8. Results: In dogs with an arterial pH of 7.40-7.45, systemic hypoxia elevated the arterial potassium by 1 mmol/L. An arterial pH of 7.55 did not alter the basal potassium concentration, but it abolished the hypoxia-induced increase. In rat muscle, reduction of the perfusate pH from 7.4 to 6.8 reduced arterial perfusion pressure from 8.73 to 7.32 kPa and venous potassium from 6.6 to 5.2 mM. Elevation of perfusate pH to 7.8 decreased the arterial perfusion pressure from 8.44 to 6.95 kPa but did not affect venous potassium. Conclusions: The hypoxia-induced elevation of arterial potassium is abolished by increasing the pH to 7.55. This is not due to enhanced potassium uptake into peripheral tissues at high pH. Red blood cells are suggested as the most likely source of the potassium released in hypoxia.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCSen_HK
dc.relation.ispartofJournal of Cardiac Surgeryen_HK
dc.titleElevation of arterial potassium during acute systemic hypoxia is abolished by alkalosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0886-0440&volume=17&spage=342&epage=346&date=2002&atitle=Elevation+of+arterial+potassium+during+acute+systemic+hypoxia+is+abolished+by+alkalosisen_HK
dc.identifier.emailBallard, HJ: ballard@hkucc.hku.hken_HK
dc.identifier.authorityBallard, HJ=rp00367en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12546084-
dc.identifier.scopuseid_2-s2.0-0036664989en_HK
dc.identifier.hkuros72914en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036664989&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue4en_HK
dc.identifier.spage342en_HK
dc.identifier.epage346en_HK
dc.identifier.isiWOS:000180205900018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMo, FFM=7005059529en_HK
dc.identifier.scopusauthoridEssackjee, HC=6507657423en_HK
dc.identifier.scopusauthoridBallard, HJ=7005286310en_HK

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