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Article: Recombinant vaccinia virus expressing PrM and E glycoproteins of louping ill virus: Induction of partial homologous and heterologous protection in mice

TitleRecombinant vaccinia virus expressing PrM and E glycoproteins of louping ill virus: Induction of partial homologous and heterologous protection in mice
Authors
Issue Date1994
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rvsc
Citation
Research In Veterinary Science, 1994, v. 57 n. 2, p. 188-193 How to Cite?
AbstractRecombinant vaccinia viruses expressing either the premembrane/truncated en-elope (PrM/TrE) or truncated envelope (TrE) protein of louping ill virus were constructed. Both constructs expressed authentic E proteins as determined by their size and antigenic reactivity with a panel of monoclonal antibodies The deletion of the C-terminal hydrophobic domain of the envelope glycoprotein resulted in the secretion of E protein into the supernatant culture medium. The immunisation of mice with these recombinant viruses showed that the recombinant expressing PrM/TrE proteins induced neutralising and protective antibodies against challenge with louping ill or tick-borne encephalitis virus, but that the recombinant expressing the E or the TrE protein alone failed to induce any detectable immune responses against homologous or heterologous virus challenge.
Persistent Identifierhttp://hdl.handle.net/10722/81314
ISSN
2015 Impact Factor: 1.504
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVenugopal, Ken_HK
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorGould, EAen_HK
dc.date.accessioned2010-09-06T08:16:15Z-
dc.date.available2010-09-06T08:16:15Z-
dc.date.issued1994en_HK
dc.identifier.citationResearch In Veterinary Science, 1994, v. 57 n. 2, p. 188-193en_HK
dc.identifier.issn0034-5288en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81314-
dc.description.abstractRecombinant vaccinia viruses expressing either the premembrane/truncated en-elope (PrM/TrE) or truncated envelope (TrE) protein of louping ill virus were constructed. Both constructs expressed authentic E proteins as determined by their size and antigenic reactivity with a panel of monoclonal antibodies The deletion of the C-terminal hydrophobic domain of the envelope glycoprotein resulted in the secretion of E protein into the supernatant culture medium. The immunisation of mice with these recombinant viruses showed that the recombinant expressing PrM/TrE proteins induced neutralising and protective antibodies against challenge with louping ill or tick-borne encephalitis virus, but that the recombinant expressing the E or the TrE protein alone failed to induce any detectable immune responses against homologous or heterologous virus challenge.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rvscen_HK
dc.relation.ispartofResearch in Veterinary Scienceen_HK
dc.titleRecombinant vaccinia virus expressing PrM and E glycoproteins of louping ill virus: Induction of partial homologous and heterologous protection in miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0034-5288&volume=57&spage=188&epage=193&date=1994&atitle=Recombinant+vaccinia+virus+expressing+PrM+and+E+glycoproteins+of+louping+ill+virus:+induction+of+partial+homologous+and+heterologous+protection+in+miceen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7529419en_HK
dc.identifier.scopuseid_2-s2.0-0028148907en_HK
dc.identifier.hkuros3218en_HK
dc.identifier.volume57en_HK
dc.identifier.issue2en_HK
dc.identifier.spage188en_HK
dc.identifier.epage193en_HK
dc.identifier.isiWOS:A1994PG01700009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridVenugopal, K=7005430227en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridGould, EA=7101857623en_HK

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