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Article: Peripheral distribution and gene expression of adrenomedullin in the rat: Possible source of blood adrenomedullin

TitlePeripheral distribution and gene expression of adrenomedullin in the rat: Possible source of blood adrenomedullin
Authors
Issue Date2000
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npep
Citation
Neuropeptides, 2000, v. 34 n. 1, p. 32-37 How to Cite?
AbstractAdrenomedullin (AM) was detected in all tissues examined with the highest concentrations in adrenal gland, lung and cardiac atrium. High concentrations of pre-proadrenomedullin mRNA were also detected in the lung, cardiac atrium, adrenal gland, thoracic aorta and mesenteric artery for the first time by solution-hybridization-RNase protection assay. The molecular forms of rat AM in various tissues and plasma were also characterized by Biogel P30 gel filtration chromatography. We found no significant difference in immunoreactive AM levels between the veins draining the kidney, the lung and the adrenal and the systemic arterial blood. The very low peptide/mRNA ratio and the AM/precursor ratio in the mesenteric artery and thoracic aorta suggest that blood vessels may be the main source of plasma AM. (C) 2000 Harcourt Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/81295
ISSN
2015 Impact Factor: 2.726
2015 SCImago Journal Rankings: 1.165
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T08:16:02Z-
dc.date.available2010-09-06T08:16:02Z-
dc.date.issued2000en_HK
dc.identifier.citationNeuropeptides, 2000, v. 34 n. 1, p. 32-37en_HK
dc.identifier.issn0143-4179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81295-
dc.description.abstractAdrenomedullin (AM) was detected in all tissues examined with the highest concentrations in adrenal gland, lung and cardiac atrium. High concentrations of pre-proadrenomedullin mRNA were also detected in the lung, cardiac atrium, adrenal gland, thoracic aorta and mesenteric artery for the first time by solution-hybridization-RNase protection assay. The molecular forms of rat AM in various tissues and plasma were also characterized by Biogel P30 gel filtration chromatography. We found no significant difference in immunoreactive AM levels between the veins draining the kidney, the lung and the adrenal and the systemic arterial blood. The very low peptide/mRNA ratio and the AM/precursor ratio in the mesenteric artery and thoracic aorta suggest that blood vessels may be the main source of plasma AM. (C) 2000 Harcourt Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npepen_HK
dc.relation.ispartofNeuropeptidesen_HK
dc.titlePeripheral distribution and gene expression of adrenomedullin in the rat: Possible source of blood adrenomedullinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-4179&volume=34&spage=32&epage=37&date=2000&atitle=Peripheral+distribution+and+gene+expression+of+adrenomedullin+in+the+rat:+possible+source+of+blood+adrenomedullinen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1054/npep.1999.0783en_HK
dc.identifier.pmid10688966-
dc.identifier.scopuseid_2-s2.0-0034023087en_HK
dc.identifier.hkuros53247en_HK
dc.identifier.hkuros58282-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034023087&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue1en_HK
dc.identifier.spage32en_HK
dc.identifier.epage37en_HK
dc.identifier.isiWOS:000085988500006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

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