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Article: Ether stress increases adrenomedullin gene expression and levels in the rat adrenal

TitleEther stress increases adrenomedullin gene expression and levels in the rat adrenal
Authors
KeywordsAdrenal
Adrenocorticotrophin
Adrenomedullin
Corticosterone
Ether stress
Hexamethonium
Rat
Issue Date2005
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/hmr
Citation
Hormone And Metabolic Research, 2005, v. 37 n. 10, p. 585-588 How to Cite?
AbstractTo study the contribution of adrenomedullin in the adrenal medulla in the stress response, we measured plasma and adrenal levels of adrenomedullin in sham-operated (intact) rats and in rats without adrenal medulla, with or without exposure to ether vapor for 15 min. Adrenomedullin levels decreased drastically after demedullation. Effect stress resulted in increased adrenomedullin levels in both adrenal and plasma in sham-operated rats, but not in demedullated rats. The responses of plasma adrenocorticotropin to stress were similar, but the elevations in plasma corticosterone levels were significantly less in demedullated rats. In the sham-operated rat, preproadrenomedullin mRNA levels were increased after stress, and this effect was not blocked by pretreatment with hexamethonium. We conclude that stress increases adrenomedullin synthesis and secretion from the adrenal medulla through a hexamethonium-insensitive mechanism, and that adrenomedullin release from the adrenal medulla may play a role in cortical steroidogenesis. © Georg Thieme Verlag KG Stuttgart.
Persistent Identifierhttp://hdl.handle.net/10722/81288
ISSN
2015 Impact Factor: 2.029
2015 SCImago Journal Rankings: 0.846
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_HK
dc.contributor.authorWong, MPFen_HK
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorLi, YYen_HK
dc.date.accessioned2010-09-06T08:15:58Z-
dc.date.available2010-09-06T08:15:58Z-
dc.date.issued2005en_HK
dc.identifier.citationHormone And Metabolic Research, 2005, v. 37 n. 10, p. 585-588en_HK
dc.identifier.issn0018-5043en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81288-
dc.description.abstractTo study the contribution of adrenomedullin in the adrenal medulla in the stress response, we measured plasma and adrenal levels of adrenomedullin in sham-operated (intact) rats and in rats without adrenal medulla, with or without exposure to ether vapor for 15 min. Adrenomedullin levels decreased drastically after demedullation. Effect stress resulted in increased adrenomedullin levels in both adrenal and plasma in sham-operated rats, but not in demedullated rats. The responses of plasma adrenocorticotropin to stress were similar, but the elevations in plasma corticosterone levels were significantly less in demedullated rats. In the sham-operated rat, preproadrenomedullin mRNA levels were increased after stress, and this effect was not blocked by pretreatment with hexamethonium. We conclude that stress increases adrenomedullin synthesis and secretion from the adrenal medulla through a hexamethonium-insensitive mechanism, and that adrenomedullin release from the adrenal medulla may play a role in cortical steroidogenesis. © Georg Thieme Verlag KG Stuttgart.en_HK
dc.languageengen_HK
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/hmren_HK
dc.relation.ispartofHormone and Metabolic Researchen_HK
dc.rightsHormone and Metabolic Research. Copyright © Georg Thieme Verlag.en_HK
dc.subjectAdrenalen_HK
dc.subjectAdrenocorticotrophinen_HK
dc.subjectAdrenomedullinen_HK
dc.subjectCorticosteroneen_HK
dc.subjectEther stressen_HK
dc.subjectHexamethoniumen_HK
dc.subjectRaten_HK
dc.titleEther stress increases adrenomedullin gene expression and levels in the rat adrenalen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0018-5043&volume=37&spage=585&epage=588&date=2005&atitle=Ether+stress+increases+adrenomedullin+gene+expression+and+levels+in+the+rat+adrenal.+en_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1055/s-2005-870534en_HK
dc.identifier.pmid16278779-
dc.identifier.scopuseid_2-s2.0-27744495062en_HK
dc.identifier.hkuros123604en_HK
dc.identifier.hkuros109127-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744495062&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue10en_HK
dc.identifier.spage585en_HK
dc.identifier.epage588en_HK
dc.identifier.isiWOS:000233195900001-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridWong, MPF=36985740400en_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridLi, YY=8293496300en_HK

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