File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Elevated spontaneous activity of phenylephrine-excited neurons in the caudal ventrolateral medulla of spontaneously hypertensive rats

TitleElevated spontaneous activity of phenylephrine-excited neurons in the caudal ventrolateral medulla of spontaneously hypertensive rats
Authors
KeywordsBlood pressure
Hypertension
Kainic acid
Neuronal firing pattern
Ventrolateral medulla
Issue Date1995
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1995, v. 22 SUPPL. 1, p. S46-S47 How to Cite?
Abstract1. The caudal ventrolateral medulla (CVLM) of pentobarbital-anaesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats was identified by the depressor response with microinjection of glutamate. 2. The mean firing rate of the spontaneously active phenylephrine-excited CVLM neurons was significantly greater in SHR than in WKY. The pattern of neuronal firing in terms of coefficient of variation and skewness of the interspike interval histogram was similar in both types of rats. 3. Administration to CVLM of kainic acid, an excitotoxic agent, led to a biphasic blood pressure response - a transient reduction followed by a gradual and sustained elevation. The elevation in blood pressure was significantly greater in SHR than in WKY. 4. These findings suggest that the barosensitive CVLM neurons are more active and the tonic inhibitory influence from CVLM to rostral ventrolateral medulla (RVLM) is greater in SHR than in WKY. It is therefore not likely that the elevated spontaneous activity of the RVLM cardiovascular neurons in SHR is due to a smaller inhibitory influence from CVLM.
Persistent Identifierhttp://hdl.handle.net/10722/81286
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944

 

DC FieldValueLanguage
dc.contributor.authorWong, TMen_HK
dc.contributor.authorYang, Zen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-06T08:15:56Z-
dc.date.available2010-09-06T08:15:56Z-
dc.date.issued1995en_HK
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1995, v. 22 SUPPL. 1, p. S46-S47en_HK
dc.identifier.issn0305-1870en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81286-
dc.description.abstract1. The caudal ventrolateral medulla (CVLM) of pentobarbital-anaesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats was identified by the depressor response with microinjection of glutamate. 2. The mean firing rate of the spontaneously active phenylephrine-excited CVLM neurons was significantly greater in SHR than in WKY. The pattern of neuronal firing in terms of coefficient of variation and skewness of the interspike interval histogram was similar in both types of rats. 3. Administration to CVLM of kainic acid, an excitotoxic agent, led to a biphasic blood pressure response - a transient reduction followed by a gradual and sustained elevation. The elevation in blood pressure was significantly greater in SHR than in WKY. 4. These findings suggest that the barosensitive CVLM neurons are more active and the tonic inhibitory influence from CVLM to rostral ventrolateral medulla (RVLM) is greater in SHR than in WKY. It is therefore not likely that the elevated spontaneous activity of the RVLM cardiovascular neurons in SHR is due to a smaller inhibitory influence from CVLM.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_HK
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_HK
dc.subjectBlood pressureen_HK
dc.subjectHypertensionen_HK
dc.subjectKainic aciden_HK
dc.subjectNeuronal firing patternen_HK
dc.subjectVentrolateral medullaen_HK
dc.titleElevated spontaneous activity of phenylephrine-excited neurons in the caudal ventrolateral medulla of spontaneously hypertensive ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=&issue=Suppl 1&spage=S16&epage=&date=1994&atitle=Elevated+spontaneous+activity+of+phenylephrine-excited+neurons+in+the+caudal+ventrolateral+medulla+of+spontaneously+hypertensive+ratsen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1681.1995.tb02965.x-
dc.identifier.pmid9072439-
dc.identifier.scopuseid_2-s2.0-0029617697en_HK
dc.identifier.hkuros3062en_HK
dc.identifier.volume22en_HK
dc.identifier.issueSUPPL. 1en_HK
dc.identifier.spageS46en_HK
dc.identifier.epageS47en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWong, TM=7403531434en_HK
dc.identifier.scopusauthoridYang, Z=16742980200en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats