File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Melatonin implant decreases the density of 2[125I]iodomelatonin binding sites in the chicken spleen

TitleMelatonin implant decreases the density of 2[125I]iodomelatonin binding sites in the chicken spleen
Authors
KeywordsBirds
Immune system
Melatonin receptors
Pineal gland
Sex steroid
Issue Date1994
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals, 1994, v. 3 n. 6, p. 278-287 How to Cite?
AbstractChanges in 2[125I]iodomelatonin binding to the chicken spleen following disruption of the normal melatonin rhythm by a slow-release melatonin implant were investigated. Melatonin capsules were implanted in 6-week-old male and female chickens reared under 12 h light/12 h darkness, The mid-light and mid-dark serum melatonin was measured throughout the period of implantation. Spleen weight and characteristics of splenic 2[125I]iodomelatonin binding sites were studied during the mid-light at 4 or 8 weeks after implantation. Melatonin implantation disrupted the normal diurnal rhythm of serum melatonin and elevated the mid-light level to the control mid-dark value until 5 weeks after implantation. The melatonin implant caused a significant decrease in the density of 2[125I]iodomelatonin binding sites at 4 weeks after implantation while there were no significant changes in the binding affinity. The reduction in 2[125I]iodomelatonin binding may be a result of down-regulation of the melatonin receptors by elevated serum melatonin. Alternatively, it may be due to an indirect suppression of 2[125I]iodomelatonin binding sites by the elevated sex hormones since melatonin implants increased the levels of testosterone in the male and estradiol in the female. Implantation of melatonin capsules significantly increased the body and spleen weights in the male chicken. These weight changes may be partly explained by the anabolic and erythropoietic action of the increased circulating testosterone.
Persistent Identifierhttp://hdl.handle.net/10722/81240
ISSN

 

DC FieldValueLanguage
dc.contributor.authorPoon, AMSen_HK
dc.contributor.authorAyre, Aen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2010-09-06T08:15:24Z-
dc.date.available2010-09-06T08:15:24Z-
dc.date.issued1994en_HK
dc.identifier.citationBiological Signals, 1994, v. 3 n. 6, p. 278-287en_HK
dc.identifier.issn1016-0922en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81240-
dc.description.abstractChanges in 2[125I]iodomelatonin binding to the chicken spleen following disruption of the normal melatonin rhythm by a slow-release melatonin implant were investigated. Melatonin capsules were implanted in 6-week-old male and female chickens reared under 12 h light/12 h darkness, The mid-light and mid-dark serum melatonin was measured throughout the period of implantation. Spleen weight and characteristics of splenic 2[125I]iodomelatonin binding sites were studied during the mid-light at 4 or 8 weeks after implantation. Melatonin implantation disrupted the normal diurnal rhythm of serum melatonin and elevated the mid-light level to the control mid-dark value until 5 weeks after implantation. The melatonin implant caused a significant decrease in the density of 2[125I]iodomelatonin binding sites at 4 weeks after implantation while there were no significant changes in the binding affinity. The reduction in 2[125I]iodomelatonin binding may be a result of down-regulation of the melatonin receptors by elevated serum melatonin. Alternatively, it may be due to an indirect suppression of 2[125I]iodomelatonin binding sites by the elevated sex hormones since melatonin implants increased the levels of testosterone in the male and estradiol in the female. Implantation of melatonin capsules significantly increased the body and spleen weights in the male chicken. These weight changes may be partly explained by the anabolic and erythropoietic action of the increased circulating testosterone.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofBiological Signalsen_HK
dc.rightsBiological Signals. Copyright © S Karger AG.en_HK
dc.subjectBirdsen_HK
dc.subjectImmune systemen_HK
dc.subjectMelatonin receptorsen_HK
dc.subjectPineal glanden_HK
dc.subjectSex steroiden_HK
dc.titleMelatonin implant decreases the density of 2[125I]iodomelatonin binding sites in the chicken spleenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1016-0922&volume=3&spage=278&epage=287&date=1994&atitle=Melatonin+implant+decreases+the+density+of+2+125I+iodomelatonin+binding+sites+in+the+chicken+spleen.en_HK
dc.identifier.emailPoon, AMS: amspoon@hkucc.hku.hken_HK
dc.identifier.authorityPoon, AMS=rp00354en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7728190-
dc.identifier.scopuseid_2-s2.0-0028598834en_HK
dc.identifier.hkuros2695en_HK
dc.identifier.volume3en_HK
dc.identifier.issue6en_HK
dc.identifier.spage278en_HK
dc.identifier.epage287en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridPoon, AMS=7103068868en_HK
dc.identifier.scopusauthoridAyre, A=6507618849en_HK
dc.identifier.scopusauthoridSong, Y=7404920869en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats