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Article: Pituitary contents of beta-endorphin, dynorphin, substance P, cholecystokinin and somatostatin in rats with streptozotocin-induced diabetes

TitlePituitary contents of beta-endorphin, dynorphin, substance P, cholecystokinin and somatostatin in rats with streptozotocin-induced diabetes
Authors
Keywordsβ-endorphin
Cholecystokinin
Diabetes
Dynorphin
Pituitary
Somatostatin
Substance P
Issue Date1996
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals, 1996, v. 5 n. 1, p. 44-50 How to Cite?
AbstractThe effects of streptozotocin-induced diabetes on pituitary neuropeptides were studied. Substance P, dynorphin and β-endorphin in both pituitary lobes and cholecystokinin and somatostatin in the neurointermediate lobe (NIL) were measured 4 weeks after streptozotocin treatment in adult male rats. There were significant decreases of substance P levels in both the anterior lobe (AL) and NIL, and of cholecystokinin, dynorphin and β-endorphin in the NIL, whereas the dynorphin content in the AL increased, when values were expressed on a perlobe basis. On a per-milligram-protein basis, however, only β-endorphin in the NIL showed a significant decrease, while AL β-endorphin and dynorphin were increased. Correlated with these changes were a drastic decrease in the serum insulin level and a marked increase in serum glucose and corticosterone levels. All these changes were reversible with insulin treatment. It is suggested that the decrease in NIL contents of neuropeptides demonstrated (except for β-endorphin) might be due to mechanisms other than a change in synthesis.
Persistent Identifierhttp://hdl.handle.net/10722/81235
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_HK
dc.contributor.authorWong, RPPen_HK
dc.date.accessioned2010-09-06T08:15:21Z-
dc.date.available2010-09-06T08:15:21Z-
dc.date.issued1996en_HK
dc.identifier.citationBiological Signals, 1996, v. 5 n. 1, p. 44-50en_HK
dc.identifier.issn1016-0922en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81235-
dc.description.abstractThe effects of streptozotocin-induced diabetes on pituitary neuropeptides were studied. Substance P, dynorphin and β-endorphin in both pituitary lobes and cholecystokinin and somatostatin in the neurointermediate lobe (NIL) were measured 4 weeks after streptozotocin treatment in adult male rats. There were significant decreases of substance P levels in both the anterior lobe (AL) and NIL, and of cholecystokinin, dynorphin and β-endorphin in the NIL, whereas the dynorphin content in the AL increased, when values were expressed on a perlobe basis. On a per-milligram-protein basis, however, only β-endorphin in the NIL showed a significant decrease, while AL β-endorphin and dynorphin were increased. Correlated with these changes were a drastic decrease in the serum insulin level and a marked increase in serum glucose and corticosterone levels. All these changes were reversible with insulin treatment. It is suggested that the decrease in NIL contents of neuropeptides demonstrated (except for β-endorphin) might be due to mechanisms other than a change in synthesis.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofBiological Signalsen_HK
dc.rightsBiological Signals. Copyright © S Karger AG.en_HK
dc.subjectβ-endorphinen_HK
dc.subjectCholecystokininen_HK
dc.subjectDiabetesen_HK
dc.subjectDynorphinen_HK
dc.subjectPituitaryen_HK
dc.subjectSomatostatinen_HK
dc.subjectSubstance Pen_HK
dc.titlePituitary contents of beta-endorphin, dynorphin, substance P, cholecystokinin and somatostatin in rats with streptozotocin-induced diabetesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1016-0922&volume=5&spage=44&epage=50&date=1996&atitle=Pituitary+contents+of+beta-endorphin,+dynorphin,+substance+P,+cholecystokinin+and+somatostatin+in+rats+with+streptozotocin-induced+diabetesen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8739322-
dc.identifier.scopuseid_2-s2.0-0029927874en_HK
dc.identifier.hkuros11679en_HK
dc.identifier.volume5en_HK
dc.identifier.issue1en_HK
dc.identifier.spage44en_HK
dc.identifier.epage50en_HK
dc.identifier.isiWOS:A1996UK56500005-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridWong, RPP=16752568700en_HK

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