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Article: Alterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron disease

TitleAlterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron disease
Authors
KeywordsAcetylcholinesterase
Cervical spinal cord
Choline acetyltransferase
Leucine-enkephalin
Methionine-enkephalin
Radioenzyme assay
Radioimmunoassay
Substance P
Thyrotropin-releasing hormone
Wobbler mouse motoneuron disease
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1994, v. 638 n. 1-2, p. 337-342 How to Cite?
AbstractEnzymatic assays for acetylcholine esterase (AChE) and choline acetyltransferase (ChAT) were applied to dorsal and ventral cervical spinal cord regions taken from the Wobbler mouse, a model for inherited motoneuron disease. Early in the disease, ChAT (but not AChE) activity is significantly greater compared with the control littermate specimens. The high ChAT activity correlates with the high thyrotropin releasing hormone (also leucine-enkephalin) concentrations measured in the Wobbler ventral horn early in the disease. Late in the motoneuron disease, both AChE and ChAT activities are significantly lower than in the control littermate specimens. These data correlate with the high substance P, methionine and leucine enkephalin concentrations measured in the Wobbler ventral horn late in the motoneuron disease.
Persistent Identifierhttp://hdl.handle.net/10722/81232
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorTang, Fen_HK
dc.contributor.authorVaccaGalloway, LLen_HK
dc.date.accessioned2010-09-06T08:15:19Z-
dc.date.available2010-09-06T08:15:19Z-
dc.date.issued1994en_HK
dc.identifier.citationBrain Research, 1994, v. 638 n. 1-2, p. 337-342en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81232-
dc.description.abstractEnzymatic assays for acetylcholine esterase (AChE) and choline acetyltransferase (ChAT) were applied to dorsal and ventral cervical spinal cord regions taken from the Wobbler mouse, a model for inherited motoneuron disease. Early in the disease, ChAT (but not AChE) activity is significantly greater compared with the control littermate specimens. The high ChAT activity correlates with the high thyrotropin releasing hormone (also leucine-enkephalin) concentrations measured in the Wobbler ventral horn early in the disease. Late in the motoneuron disease, both AChE and ChAT activities are significantly lower than in the control littermate specimens. These data correlate with the high substance P, methionine and leucine enkephalin concentrations measured in the Wobbler ventral horn late in the motoneuron disease.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subjectAcetylcholinesteraseen_HK
dc.subjectCervical spinal corden_HK
dc.subjectCholine acetyltransferaseen_HK
dc.subjectLeucine-enkephalinen_HK
dc.subjectMethionine-enkephalinen_HK
dc.subjectRadioenzyme assayen_HK
dc.subjectRadioimmunoassayen_HK
dc.subjectSubstance Pen_HK
dc.subjectThyrotropin-releasing hormoneen_HK
dc.subjectWobbler mouse motoneuron diseaseen_HK
dc.titleAlterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=638&spage=337&epage=342&date=1994&atitle=Alterations+in+acetylcholinesterase+and+choline+acetyltransferase+activities+and+neuropeptide+levels+in+the+ventral+spinal+cord+of+the+wobbler+mouse+during+inherited+motoneuron+diseaseen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7515324-
dc.identifier.scopuseid_2-s2.0-0028069465en_HK
dc.identifier.hkuros6170en_HK
dc.identifier.volume638en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage337en_HK
dc.identifier.epage342en_HK
dc.identifier.isiWOS:A1994MZ35500043-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridYung, KKL=36840201600en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridVaccaGalloway, LL=6602468305en_HK

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