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Article: Effects of angiotensin II on the spontaneous activity of rostral ventrolateral medullary cardiovascular neurons and blood pressure in spontaneously hypertensive rats

TitleEffects of angiotensin II on the spontaneous activity of rostral ventrolateral medullary cardiovascular neurons and blood pressure in spontaneously hypertensive rats
Authors
KeywordsAngiotensin II
Arterial blood pressure
Cardiovascular neurons
Hypertension
Rostral ventrolateral medulla
Issue Date1996
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1021-7770
Citation
Journal Of Biomedical Science, 1996, v. 3 n. 3, p. 191-202 How to Cite?
AbstractThe interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesthetized spontaneously hypertensive rat (SHR) and its normotensive control, the Wistar Kyoto rat (WKY). It was found that Ang II elicited dose-dependent excitatory responses in a subpopulation of RVL cardiovascular neurons, followed by a subsequent increase in blood pressure. These effects of Ang II were significantly greater in SHR than in WKY. The effects were attenuated or abolished by co- administration of Ang II antagonist, [Sar1, Ile8]-Ang II. Pre- administration of [Sar1, Ile8]-Ang II to RVL using bilateral microinjection attenuated the blood pressure effects of intracerebroventricularly administered Ang II by as much as 70%. These results indicated that spinal projecting RVL cardiovascular neurons are important in mediating the pressor action of Ang II. The enhanced sensitivity and responsiveness of RVL cardiovascular neurons to Ang II may be pertinent to the genesis of hypertension in adult SHR.
Persistent Identifierhttp://hdl.handle.net/10722/81226
ISSN
2015 Impact Factor: 2.935
2015 SCImago Journal Rankings: 1.280
References

 

DC FieldValueLanguage
dc.contributor.authorChan, RKWen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorWong, TMen_HK
dc.date.accessioned2010-09-06T08:15:15Z-
dc.date.available2010-09-06T08:15:15Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Biomedical Science, 1996, v. 3 n. 3, p. 191-202en_HK
dc.identifier.issn1021-7770en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81226-
dc.description.abstractThe interactive role of rostral ventrolateral medulla (RVL) cardiovascular neurons and brain angiotensin II (Ang II) in regulating the arterial blood pressure was examined by recording simultaneously the spontaneous activity of these spinal projecting neurons and the arterial blood pressure in the pentobarbital-anesthetized spontaneously hypertensive rat (SHR) and its normotensive control, the Wistar Kyoto rat (WKY). It was found that Ang II elicited dose-dependent excitatory responses in a subpopulation of RVL cardiovascular neurons, followed by a subsequent increase in blood pressure. These effects of Ang II were significantly greater in SHR than in WKY. The effects were attenuated or abolished by co- administration of Ang II antagonist, [Sar1, Ile8]-Ang II. Pre- administration of [Sar1, Ile8]-Ang II to RVL using bilateral microinjection attenuated the blood pressure effects of intracerebroventricularly administered Ang II by as much as 70%. These results indicated that spinal projecting RVL cardiovascular neurons are important in mediating the pressor action of Ang II. The enhanced sensitivity and responsiveness of RVL cardiovascular neurons to Ang II may be pertinent to the genesis of hypertension in adult SHR.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1021-7770en_HK
dc.relation.ispartofJournal of Biomedical Scienceen_HK
dc.subjectAngiotensin IIen_HK
dc.subjectArterial blood pressureen_HK
dc.subjectCardiovascular neuronsen_HK
dc.subjectHypertensionen_HK
dc.subjectRostral ventrolateral medullaen_HK
dc.titleEffects of angiotensin II on the spontaneous activity of rostral ventrolateral medullary cardiovascular neurons and blood pressure in spontaneously hypertensive ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1021-7770&volume=3&spage=191&epage=202&date=1996&atitle=Effects+of+angiotensin+II+on+the+spontaneous+activity+of+rostral+ventrolateral+medullary+cardiovascular+neurons+and+blood+pressure+in+spontaneously+hypertensive+ratsen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0029740525en_HK
dc.identifier.hkuros25597en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029740525&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue3en_HK
dc.identifier.spage191en_HK
dc.identifier.epage202en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChan, RKW=7403110878en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridWong, TM=7403531434en_HK

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