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Conference Paper: Adrenomedullin: A cardiac depressant factor in septic shock

TitleAdrenomedullin: A cardiac depressant factor in septic shock
Authors
Issue Date2002
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCS
Citation
The 1st international Symposium of Cardiovascular Science, Hong Kong, China, 23-24 November 2001. In Journal of Cardiac Surgery, 2002, v. 17 n. 4, p. 328-335 How to Cite?
AbstractDespite intensive research, septic shock is still the most common cause of death in surgical intensive care, and its incidence keeps increasing.1,2 No curative treatment is yet available. The critical aspect of septic shock is the refractory hypotension that develops during its late phase which leads to a progressive deterioration of cell and organ functions,3 and in most instances, death. During septic shock, following the overproduction of cytokines,4 many factors such as nitric oxide5 and adrenomedullin (ADM)6 are produced in abnormally large quantities, but our understanding of their contribution to the pathophysiology of sepsis is limited. Here we show that adrenomedullin (22-52), an adrenomedullin receptor antagonist,7 improves the contractility of myocytes isolated from lipopolysaccharide (LPS)-treated rats, whereas in normal myocytes, adrenomedullin, acting through an adrenomedullin (22-52) sensitive receptor, decreases their contractility. In addition, adrenomedullin anti-serum and inducible nitric oxide (NO) synthase inhibitor improve the survival of LPS-treated rats. The data indicate that adrenomedullin is a cardiac depressant factor, which along with NO8 precipitates ventricular failure during septic shock.
DescriptionConference Theme: From Bench to Bedside
Persistent Identifierhttp://hdl.handle.net/10722/81223
ISSN
2015 Impact Factor: 0.783
2015 SCImago Journal Rankings: 0.578
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHyvelin, JMen_HK
dc.contributor.authorShan, Qen_HK
dc.contributor.authorBourreau, JPen_HK
dc.date.accessioned2010-09-06T08:15:13Z-
dc.date.available2010-09-06T08:15:13Z-
dc.date.issued2002en_HK
dc.identifier.citationThe 1st international Symposium of Cardiovascular Science, Hong Kong, China, 23-24 November 2001. In Journal of Cardiac Surgery, 2002, v. 17 n. 4, p. 328-335en_HK
dc.identifier.issn0886-0440en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81223-
dc.descriptionConference Theme: From Bench to Bedside-
dc.description.abstractDespite intensive research, septic shock is still the most common cause of death in surgical intensive care, and its incidence keeps increasing.1,2 No curative treatment is yet available. The critical aspect of septic shock is the refractory hypotension that develops during its late phase which leads to a progressive deterioration of cell and organ functions,3 and in most instances, death. During septic shock, following the overproduction of cytokines,4 many factors such as nitric oxide5 and adrenomedullin (ADM)6 are produced in abnormally large quantities, but our understanding of their contribution to the pathophysiology of sepsis is limited. Here we show that adrenomedullin (22-52), an adrenomedullin receptor antagonist,7 improves the contractility of myocytes isolated from lipopolysaccharide (LPS)-treated rats, whereas in normal myocytes, adrenomedullin, acting through an adrenomedullin (22-52) sensitive receptor, decreases their contractility. In addition, adrenomedullin anti-serum and inducible nitric oxide (NO) synthase inhibitor improve the survival of LPS-treated rats. The data indicate that adrenomedullin is a cardiac depressant factor, which along with NO8 precipitates ventricular failure during septic shock.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCSen_HK
dc.relation.ispartofJournal of Cardiac Surgeryen_HK
dc.titleAdrenomedullin: A cardiac depressant factor in septic shocken_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0886-0440&volume=17&spage=328&epage=335&date=2002&atitle=Adrenomedullin:+A+cardiac+depressant+factor+in+septic+shock.+en_HK
dc.identifier.emailBourreau, JP: bourreau@hkucc.hku.hken_HK
dc.identifier.authorityBourreau, JP=rp00389en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1540-8191.2001.tb01152.x-
dc.identifier.pmid12546081-
dc.identifier.scopuseid_2-s2.0-12244298914en_HK
dc.identifier.hkuros82128en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12244298914&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue4en_HK
dc.identifier.spage328en_HK
dc.identifier.epage335en_HK
dc.identifier.isiWOS:000180205900015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHyvelin, JM=6602435488en_HK
dc.identifier.scopusauthoridShan, Q=7007145043en_HK
dc.identifier.scopusauthoridBourreau, JP=7003927886en_HK
dc.customcontrol.immutablesml 160602 amended-

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