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Article: Melatonin-induced stimulation of rat corpus epididymal epithelial cell proliferation

TitleMelatonin-induced stimulation of rat corpus epididymal epithelial cell proliferation
Authors
Keywords5α-dihydrotestosterone
Cell cycle distribution
Cell proliferation
CGP 52608
Melatonin
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1999, v. 65 n. 10, p. 1067-1076 How to Cite?
AbstractStimulation of rat epididymal epithelial cell proliferation by melatonin was demonstrated by thymidine incorporation and flow cytometric analyses. The stimulatory effect of melatonin was dependent on the hormone concentration and the duration of cell exposure to the hormone. Maximal stimulation of [ 3H]thymidine incorporation into epididymal epithelial cells by melatonin was observed at 1x10 -9 M 5α-dihydrotestosterone in medium, while lower or higher concentrations of androgen attenuated the stimulatory effect of melatonin. Interestingly, a nuclear melatonin receptor agonist (1-[3-allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemi-carbazone, CGP 52608) induced opposite effect on epithelial cell proliferation to that produced by melatonin. Our data suggest that melatonin-induced stimulation of rat epididymal epithelial cell proliferation is not likely to be mediated by nuclear receptor. Furthermore, sequential changes of cell cycle distribution with melatonin treatment also supports a stimulatory action of melatonin on epididymal epithelial cell proliferation.
Persistent Identifierhttp://hdl.handle.net/10722/81214
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Len_HK
dc.contributor.authorWong, JTYen_HK
dc.contributor.authorPang, SFen_HK
dc.contributor.authorShiu, SYWen_HK
dc.date.accessioned2010-09-06T08:15:07Z-
dc.date.available2010-09-06T08:15:07Z-
dc.date.issued1999en_HK
dc.identifier.citationLife Sciences, 1999, v. 65 n. 10, p. 1067-1076en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81214-
dc.description.abstractStimulation of rat epididymal epithelial cell proliferation by melatonin was demonstrated by thymidine incorporation and flow cytometric analyses. The stimulatory effect of melatonin was dependent on the hormone concentration and the duration of cell exposure to the hormone. Maximal stimulation of [ 3H]thymidine incorporation into epididymal epithelial cells by melatonin was observed at 1x10 -9 M 5α-dihydrotestosterone in medium, while lower or higher concentrations of androgen attenuated the stimulatory effect of melatonin. Interestingly, a nuclear melatonin receptor agonist (1-[3-allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemi-carbazone, CGP 52608) induced opposite effect on epithelial cell proliferation to that produced by melatonin. Our data suggest that melatonin-induced stimulation of rat epididymal epithelial cell proliferation is not likely to be mediated by nuclear receptor. Furthermore, sequential changes of cell cycle distribution with melatonin treatment also supports a stimulatory action of melatonin on epididymal epithelial cell proliferation.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subject5α-dihydrotestosteroneen_HK
dc.subjectCell cycle distributionen_HK
dc.subjectCell proliferationen_HK
dc.subjectCGP 52608en_HK
dc.subjectMelatoninen_HK
dc.titleMelatonin-induced stimulation of rat corpus epididymal epithelial cell proliferationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=65&spage=1067&epage=1076&date=1999&atitle=Melatonin-induced+stimulation+of+rat+corpus+epididymal+epithelial+cell+proliferation.en_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.emailPang, SF: hrmypsf@hkucc.hku.hk-
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(99)00337-9en_HK
dc.identifier.pmid10499874-
dc.identifier.scopuseid_2-s2.0-0033618494en_HK
dc.identifier.hkuros51400en_HK
dc.identifier.hkuros46317-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033618494&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1067en_HK
dc.identifier.epage1076en_HK
dc.identifier.isiWOS:000081876100010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, L=36986014500en_HK
dc.identifier.scopusauthoridWong, JTY=24467064200en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK

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