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Article: Endothelium-dependent effect of bradykinin and ATP on rabbit ventricular myocytes

TitleEndothelium-dependent effect of bradykinin and ATP on rabbit ventricular myocytes
Authors
KeywordsATP
Bradykinin
Cardiac myocytes
Endothelial cells
Fura-2
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1999, v. 64 n. 24, p. PL291-PL296 How to Cite?
AbstractWe have investigated the effects of bradykinin (BK) and ATP on Ca2+ transient induced by electrical-field stimulation in freshly isolated rabbit ventricular myocytes, in the presence or absence of rabbit aortic endothelial cells. BK and ATP induced an increase in intracellular Ca2+ concentration ([Ca2+](i)) in the endothelial cells, but had no significant effect on Ca2+ transient in electrical-field stimulated ventricular myocytes. In the presence of cultured endothelial cells, the amplitude of Ca2+ transient induced by electrical stimulation in ventricular myocytes was decreased. BK and ATP further reduced the amplitude of Ca2+ transient induced by electrical stimulation in ventricular myocytes. These data show that BK and ATP have endothelium-dependent depressing effects on ventricular myocytes and indicate that substances released from endothelial cells in response to BK and ATP stimulation can modulate ventricular myocytes excitation-contraction coupling. However, identification of the cardioactive mediators produced by the endothelial cells requires further study.
Persistent Identifierhttp://hdl.handle.net/10722/81202
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOu, YJen_HK
dc.contributor.authorShan, QXen_HK
dc.contributor.authorBourreau, JPen_HK
dc.date.accessioned2010-09-06T08:14:59Z-
dc.date.available2010-09-06T08:14:59Z-
dc.date.issued1999en_HK
dc.identifier.citationLife Sciences, 1999, v. 64 n. 24, p. PL291-PL296en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81202-
dc.description.abstractWe have investigated the effects of bradykinin (BK) and ATP on Ca2+ transient induced by electrical-field stimulation in freshly isolated rabbit ventricular myocytes, in the presence or absence of rabbit aortic endothelial cells. BK and ATP induced an increase in intracellular Ca2+ concentration ([Ca2+](i)) in the endothelial cells, but had no significant effect on Ca2+ transient in electrical-field stimulated ventricular myocytes. In the presence of cultured endothelial cells, the amplitude of Ca2+ transient induced by electrical stimulation in ventricular myocytes was decreased. BK and ATP further reduced the amplitude of Ca2+ transient induced by electrical stimulation in ventricular myocytes. These data show that BK and ATP have endothelium-dependent depressing effects on ventricular myocytes and indicate that substances released from endothelial cells in response to BK and ATP stimulation can modulate ventricular myocytes excitation-contraction coupling. However, identification of the cardioactive mediators produced by the endothelial cells requires further study.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectATPen_HK
dc.subjectBradykininen_HK
dc.subjectCardiac myocytesen_HK
dc.subjectEndothelial cellsen_HK
dc.subjectFura-2en_HK
dc.titleEndothelium-dependent effect of bradykinin and ATP on rabbit ventricular myocytesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=64&issue=24&spage=291&epage=296&date=1999&atitle=Endothelium-dependent+effect+of+bradykinin+and+ATP+on+rabbit+ventricular+myocytesen_HK
dc.identifier.emailBourreau, JP: bourreau@hkucc.hku.hken_HK
dc.identifier.authorityBourreau, JP=rp00389en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(99)00182-4en_HK
dc.identifier.pmid10374921-
dc.identifier.scopuseid_2-s2.0-0033532371en_HK
dc.identifier.hkuros44390en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033532371&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue24en_HK
dc.identifier.spagePL291en_HK
dc.identifier.epagePL296en_HK
dc.identifier.isiWOS:000080323000015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOu, YJ=7102690345en_HK
dc.identifier.scopusauthoridShan, QX=7007145043en_HK
dc.identifier.scopusauthoridBourreau, JP=7003927886en_HK

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