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Article: Streptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: A study by solution-hybridization-RNase protection assay

TitleStreptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: A study by solution-hybridization-RNase protection assay
Authors
KeywordsAtrial natriuretic peptide
Rat
Solution-hybridization-RNase protection assay
Streptozotocin
Issue Date1998
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
Citation
Diabetologia, 1998, v. 41 n. 6, p. 660-665 How to Cite?
AbstractIn rats with streptozotocin (STZ)-diabetes for 2 or 4 weeks, the atrial natriuretic peptide (ANP) concentrations in the atria decreased whilst that of ANP in the plasma and ventricles increased. ANP concentrations in the hypothalamus and in the brainstem did not change in either 2- or 4-week diabetic rats. Atrial ANP content was partly restored by insulin replacement in 4-week diabetic rats. Plasma ANP concentrations and ventricular ANP contents were reversed to normal by insulin treatment in both 2- and 4-week diabetic rats. Solution-hybridization-RNase-protection assay showed a significant increase in the preproANP mRNA expression in the ventricles but not in the atria. These results indicated that the STZ-diabetes increased the synthesis of ANP in the ventricles and consequently its release from the ventricles. The synthesis of ANP in the atria did not change as judged from the preproANP mRNA expression but the release of ANP from the atria might also be increased for ANP content decreased in the atria. The reason for the difference in the response of atrial and ventricular preproANP concentrations to STZ-diabetes is not known.
Persistent Identifierhttp://hdl.handle.net/10722/81186
ISSN
2015 Impact Factor: 6.206
2015 SCImago Journal Rankings: 3.528
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, SQen_HK
dc.contributor.authorKwan, CYen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T08:14:48Z-
dc.date.available2010-09-06T08:14:48Z-
dc.date.issued1998en_HK
dc.identifier.citationDiabetologia, 1998, v. 41 n. 6, p. 660-665en_HK
dc.identifier.issn0012-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/81186-
dc.description.abstractIn rats with streptozotocin (STZ)-diabetes for 2 or 4 weeks, the atrial natriuretic peptide (ANP) concentrations in the atria decreased whilst that of ANP in the plasma and ventricles increased. ANP concentrations in the hypothalamus and in the brainstem did not change in either 2- or 4-week diabetic rats. Atrial ANP content was partly restored by insulin replacement in 4-week diabetic rats. Plasma ANP concentrations and ventricular ANP contents were reversed to normal by insulin treatment in both 2- and 4-week diabetic rats. Solution-hybridization-RNase-protection assay showed a significant increase in the preproANP mRNA expression in the ventricles but not in the atria. These results indicated that the STZ-diabetes increased the synthesis of ANP in the ventricles and consequently its release from the ventricles. The synthesis of ANP in the atria did not change as judged from the preproANP mRNA expression but the release of ANP from the atria might also be increased for ANP content decreased in the atria. The reason for the difference in the response of atrial and ventricular preproANP concentrations to STZ-diabetes is not known.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htmen_HK
dc.relation.ispartofDiabetologiaen_HK
dc.subjectAtrial natriuretic peptideen_HK
dc.subjectRaten_HK
dc.subjectSolution-hybridization-RNase protection assayen_HK
dc.subjectStreptozotocinen_HK
dc.titleStreptozotocin-induced diabetes has differential effects on atrial natriuretic peptide synthesis in the rat atrium and ventricle: A study by solution-hybridization-RNase protection assayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-186X&volume=41&spage=660&epage=665&date=1998&atitle=Streptozotocin-induced+diabetes+has+differential+effects+on+atrial+natriuretic+peptide+synthesis+in+the+rat+atrium+and+ventricle:+a+study++by+solution-hybridization+RNase+protection+assayen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s001250050965en_HK
dc.identifier.pmid9662047-
dc.identifier.scopuseid_2-s2.0-0031812694en_HK
dc.identifier.hkuros36682en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031812694&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue6en_HK
dc.identifier.spage660en_HK
dc.identifier.epage665en_HK
dc.identifier.isiWOS:000074102000008-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWu, SQ=7407180073en_HK
dc.identifier.scopusauthoridKwan, CY=7201421224en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

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