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Article: Adenosine output from dog gracilis muscle during systemic hypercapnia and/or amiloride-SITS infusion

TitleAdenosine output from dog gracilis muscle during systemic hypercapnia and/or amiloride-SITS infusion
Authors
Keywordsacidosis
carbon dioxide
intracellular pH
regulation of adenosine formation
Issue Date1994
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1994, v. 267 n. 4 36-4, p. H1243-H1249 How to Cite?
AbstractThe influence of acidosis on adenosine output from the isolated constant- flow-perfused gracilis muscle was studied in anesthetized dogs. Depression of intracellular pH (pH(i)) by supplementation of the inspired air with 10% CO2-90% O2 increased arterial PCO2 from 34.2 ± 1.0 to 53.5 ± 1.9 mmHg, arterial PO2 from 138.3 ± 3.9 to 256.6 ± 17.6 mmHg, and venoarterial adenosine concentration from 14 ± 15 to 47 ± 19 nM. Twitch contractions of the muscle at 2 Hz increased venoarterial adenosine concentration to 165 ± 63 and 204 ± 62 nM in normocapnia and hypercapnia, respectively. Venoarterial lactate concentration increased from 0.42 ± 0.07 to 0.90 ± 0.15 mM during normocapnic contractions but remained unchanged during hypercapnic contractions (0.42 ± 0.11 mM). Depression of pH(i) by infusion of amiloride and 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid increased venoarterial adenosine concentration from -2 ± 27 to 124 ± 48 nM in normocapnia and from 16 ± 24 to 236 ± 119 nM in hypercapnia. These results indicate that adenosine output from red oxidative skeletal muscle was stimulated by procedures that depress pH(i).
Persistent Identifierhttp://hdl.handle.net/10722/81184
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823

 

DC FieldValueLanguage
dc.contributor.authorMo, FMen_HK
dc.contributor.authorBallard, HJen_HK
dc.date.accessioned2010-09-06T08:14:47Z-
dc.date.available2010-09-06T08:14:47Z-
dc.date.issued1994en_HK
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1994, v. 267 n. 4 36-4, p. H1243-H1249en_HK
dc.identifier.issn0363-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81184-
dc.description.abstractThe influence of acidosis on adenosine output from the isolated constant- flow-perfused gracilis muscle was studied in anesthetized dogs. Depression of intracellular pH (pH(i)) by supplementation of the inspired air with 10% CO2-90% O2 increased arterial PCO2 from 34.2 ± 1.0 to 53.5 ± 1.9 mmHg, arterial PO2 from 138.3 ± 3.9 to 256.6 ± 17.6 mmHg, and venoarterial adenosine concentration from 14 ± 15 to 47 ± 19 nM. Twitch contractions of the muscle at 2 Hz increased venoarterial adenosine concentration to 165 ± 63 and 204 ± 62 nM in normocapnia and hypercapnia, respectively. Venoarterial lactate concentration increased from 0.42 ± 0.07 to 0.90 ± 0.15 mM during normocapnic contractions but remained unchanged during hypercapnic contractions (0.42 ± 0.11 mM). Depression of pH(i) by infusion of amiloride and 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid increased venoarterial adenosine concentration from -2 ± 27 to 124 ± 48 nM in normocapnia and from 16 ± 24 to 236 ± 119 nM in hypercapnia. These results indicate that adenosine output from red oxidative skeletal muscle was stimulated by procedures that depress pH(i).en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_HK
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_HK
dc.subjectacidosisen_HK
dc.subjectcarbon dioxideen_HK
dc.subjectintracellular pHen_HK
dc.subjectregulation of adenosine formationen_HK
dc.titleAdenosine output from dog gracilis muscle during systemic hypercapnia and/or amiloride-SITS infusionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9513&volume=267 &issue=Heart Circ Physiol 36&spage=H1243&epage=H1249&date=1994&atitle=Adenosine+output+from+dog+gracilis+muscle+during+systemic+hypercapnia+and/or+amiloride/SITS+infusionen_HK
dc.identifier.emailBallard, HJ: ballard@hkucc.hku.hken_HK
dc.identifier.authorityBallard, HJ=rp00367en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7943367-
dc.identifier.scopuseid_2-s2.0-0027943045en_HK
dc.identifier.hkuros38362en_HK
dc.identifier.hkuros3014-
dc.identifier.volume267en_HK
dc.identifier.issue4 36-4en_HK
dc.identifier.spageH1243en_HK
dc.identifier.epageH1249en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMo, FM=7005059536en_HK
dc.identifier.scopusauthoridBallard, HJ=7005286310en_HK

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