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Article: Characterization of ventilatory responses to hypoxia in neonatal rats

TitleCharacterization of ventilatory responses to hypoxia in neonatal rats
Authors
KeywordsControl of breathing, hypoxic response
Development, neonatal rat
Hypoxia, ventilatory response
Mammals, rat
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol
Citation
Respiration Physiology, 1996, v. 103 n. 1, p. 57-66 How to Cite?
AbstractNewborn animals exhibit a biphasic response to hypoxia, with ventilation increasing and then declining. Our purpose was to define if this response could be supported by the pontile and medullary respiratory centers. Spontaneously breathing and paralyzed and ventilated decerebrate or anesthetized, vagotomized rats were studied from birth to 13 days thereafter. Peak integrated phrenic activity, or tidal volume, and frequency initially increased and then declined after inspired oxygen was reduced from hyperoxic to hypoxic levels; most animals became apneic in hypoxia. Apnea occurred in a greater proportion of animals and more quickly with more severe hypoxia. Following sectioning of the carotid sinus nerves, ventilatory activity declined with a change from hyperoxia to normoxia. We conclude that the biphasic ventilatory response to hypoxia represents a balance between synaptically-induced augmentations and reductions of brainstem neuronal activities. The carotid chemoreceptors play a fundamental role in the augmentations, and reductions appear dependent upon actions of hypoxia upon brainstem mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/81169
ISSN
2001 Impact Factor: 2.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_HK
dc.contributor.authorWang, Wen_HK
dc.contributor.authorDarnall, RAen_HK
dc.contributor.authorSt John, WMen_HK
dc.date.accessioned2010-09-06T08:14:37Z-
dc.date.available2010-09-06T08:14:37Z-
dc.date.issued1996en_HK
dc.identifier.citationRespiration Physiology, 1996, v. 103 n. 1, p. 57-66en_HK
dc.identifier.issn0034-5687en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81169-
dc.description.abstractNewborn animals exhibit a biphasic response to hypoxia, with ventilation increasing and then declining. Our purpose was to define if this response could be supported by the pontile and medullary respiratory centers. Spontaneously breathing and paralyzed and ventilated decerebrate or anesthetized, vagotomized rats were studied from birth to 13 days thereafter. Peak integrated phrenic activity, or tidal volume, and frequency initially increased and then declined after inspired oxygen was reduced from hyperoxic to hypoxic levels; most animals became apneic in hypoxia. Apnea occurred in a greater proportion of animals and more quickly with more severe hypoxia. Following sectioning of the carotid sinus nerves, ventilatory activity declined with a change from hyperoxia to normoxia. We conclude that the biphasic ventilatory response to hypoxia represents a balance between synaptically-induced augmentations and reductions of brainstem neuronal activities. The carotid chemoreceptors play a fundamental role in the augmentations, and reductions appear dependent upon actions of hypoxia upon brainstem mechanisms.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiolen_HK
dc.relation.ispartofRespiration Physiologyen_HK
dc.rightsRespiratory Physiology. Copyright © Elsevier BV.en_HK
dc.subjectControl of breathing, hypoxic responseen_HK
dc.subjectDevelopment, neonatal raten_HK
dc.subjectHypoxia, ventilatory responseen_HK
dc.subjectMammals, raten_HK
dc.titleCharacterization of ventilatory responses to hypoxia in neonatal ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0034-5687&volume=103&spage=57&epage=66&date=1996&atitle=Characterization+of+ventilatory+responses+to+hypoxia+in+neonatal+ratsen_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0034-5687(95)00077-1en_HK
dc.identifier.pmid8822223-
dc.identifier.scopuseid_2-s2.0-0030044167en_HK
dc.identifier.hkuros26244en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030044167&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue1en_HK
dc.identifier.spage57en_HK
dc.identifier.epage66en_HK
dc.identifier.isiWOS:A1996TU27800006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridFung, ML=7101955092en_HK
dc.identifier.scopusauthoridWang, W=7501756233en_HK
dc.identifier.scopusauthoridDarnall, RA=7003629071en_HK
dc.identifier.scopusauthoridSt John, WM=36831054200en_HK

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