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Article: A molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypes

TitleA molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypes
Authors
KeywordsAmino acid homology
Chicken
Human
Melatonin receptor
Phylogenetic analysis
Sequence alignment
Xenopus
Issue Date1996
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPI
Citation
Journal Of Pineal Research, 1996, v. 20 n. 4, p. 198-204 How to Cite?
AbstractSuccessful cloning of melatonin receptors from various target tissues in the past few years has increased our understanding of the molecular signal transduction mechanisms of G-protein coupled melatonin receptors, of which three subtypes (MEL-1A, MEL-1B, and MEL-1C) have been reported in different vertebrates. Based upon melatonin receptor sequences available in the Genbank database, we have performed phylogenetic analyses of the nucleotide and encoded amino acid sequences of G-protein-coupled melatonin receptors, and determined the range of amino acid identities between melatonin receptors of the same and different subtypes. Besides the three well-known subtypes, a potential novel subtype of MEL-1D, as exemplified by unique separation of Xenopus X2.0 sequence (Genbank accession No. U31826) from the others in the protein phylogenetic tree, possibly exists. In addition, one of the chicken brain melatonin receptor sequences has been identified as belonging to the MEL-1B subtype. Our analyses showed that melatonin receptors of the same subtype and different subtypes are likely to share ≥75% and <65% amino acid identities, respectively. Phylogenetic analysis based on amino acid comparisons will be needed to determine the subtype status of any pair of melatonin receptor sequences that exhibit ≥65% to <75% amino acid identity. Despite the usefulness of genetic relatedness in the subtype classification of G-protein-coupled melatonin receptors, functional correlation of molecular structure may ultimately prove the most comprehensive approach in melatonin receptor classification. © Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/81162
ISSN
2015 Impact Factor: 9.314
2015 SCImago Journal Rankings: 2.655
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorNg, Nen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2010-09-06T08:14:32Z-
dc.date.available2010-09-06T08:14:32Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Pineal Research, 1996, v. 20 n. 4, p. 198-204en_HK
dc.identifier.issn0742-3098en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81162-
dc.description.abstractSuccessful cloning of melatonin receptors from various target tissues in the past few years has increased our understanding of the molecular signal transduction mechanisms of G-protein coupled melatonin receptors, of which three subtypes (MEL-1A, MEL-1B, and MEL-1C) have been reported in different vertebrates. Based upon melatonin receptor sequences available in the Genbank database, we have performed phylogenetic analyses of the nucleotide and encoded amino acid sequences of G-protein-coupled melatonin receptors, and determined the range of amino acid identities between melatonin receptors of the same and different subtypes. Besides the three well-known subtypes, a potential novel subtype of MEL-1D, as exemplified by unique separation of Xenopus X2.0 sequence (Genbank accession No. U31826) from the others in the protein phylogenetic tree, possibly exists. In addition, one of the chicken brain melatonin receptor sequences has been identified as belonging to the MEL-1B subtype. Our analyses showed that melatonin receptors of the same subtype and different subtypes are likely to share ≥75% and <65% amino acid identities, respectively. Phylogenetic analysis based on amino acid comparisons will be needed to determine the subtype status of any pair of melatonin receptor sequences that exhibit ≥65% to <75% amino acid identity. Despite the usefulness of genetic relatedness in the subtype classification of G-protein-coupled melatonin receptors, functional correlation of molecular structure may ultimately prove the most comprehensive approach in melatonin receptor classification. © Munksgaard.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPIen_HK
dc.relation.ispartofJournal of Pineal Researchen_HK
dc.subjectAmino acid homologyen_HK
dc.subjectChickenen_HK
dc.subjectHumanen_HK
dc.subjectMelatonin receptoren_HK
dc.subjectPhylogenetic analysisen_HK
dc.subjectSequence alignmenten_HK
dc.subjectXenopusen_HK
dc.titleA molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0742-3098&volume=20&spage=198&epage=204&date=1996&atitle=A+molecular+perspective+of+the+genetic+relationships+of+G-protein+coupled+melatonin+receptor+subtypesen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-079X.1996.tb00259.x-
dc.identifier.pmid8836953-
dc.identifier.scopuseid_2-s2.0-0030135754en_HK
dc.identifier.hkuros24621en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030135754&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue4en_HK
dc.identifier.spage198en_HK
dc.identifier.epage204en_HK
dc.identifier.isiWOS:A1996UW86300004-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridNg, N=36641702700en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK

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