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Article: Role of dorsal motor nucleus of vagus in gastric function and mucosal damage induced by ethanol in rats

TitleRole of dorsal motor nucleus of vagus in gastric function and mucosal damage induced by ethanol in rats
Authors
KeywordsDorsal motor nucleus of vagus
Ethanol
Gastric acid secretion
Gastric damage
Gastric mucosal blood flow
Issue Date1995
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1995, v. 40 n. 11, p. 2312-2316 How to Cite?
AbstractExperimental evidence indicates that the autonomic nervous system, especially the cholinergic pathway, modulates the mucosal defensive mechanism and affects mucosal damage in the stomach. The present study investigated the role of the dorsal motor nucleus of vagus (DMV) in gastric function and its influences on ethanol-induced mucosal damage in pentobarbitone-anesthetized rats. Electrolytic lesion of the DMV as compared with sham operation and lesions of other brain areas, eg, nucleus reticular gigantocellularis and cuneate nucleus, reduced the basal gastric mucosal blood flow (GMBF) and also the blood flow after ethanol administration. The same operation did not affect the acid secretion either in the basal state or during the ethanol treatment period. Lesions at the caudal half of the DMV produced a bigger depression of GMBF when compared with lesion at the rostral half. In the sham-operated rats, ethanol induced severe hemorrhagic lesions in the gastric glandular mucosa, and this was significantly potentiated by lesions at the DMV, especially in the caudal half. The present findings indicate that acute DMV damage at the caudal half markedly affects the GMBF but not the acid secretion. The action on GMBF may contribute to the aggravation of ethanol-induced gastric damage in rats. These data reinforce the idea that the central vagal pathway, especially the caudal half of the DMV, plays a significant role in the modulation of GMBF, which in turn affects the integrity of gastric mucosal barrier.
Persistent Identifierhttp://hdl.handle.net/10722/81146
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, YSen_HK
dc.contributor.authorKo, JKSen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:14:21Z-
dc.date.available2010-09-06T08:14:21Z-
dc.date.issued1995en_HK
dc.identifier.citationDigestive Diseases And Sciences, 1995, v. 40 n. 11, p. 2312-2316en_HK
dc.identifier.issn0163-2116en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81146-
dc.description.abstractExperimental evidence indicates that the autonomic nervous system, especially the cholinergic pathway, modulates the mucosal defensive mechanism and affects mucosal damage in the stomach. The present study investigated the role of the dorsal motor nucleus of vagus (DMV) in gastric function and its influences on ethanol-induced mucosal damage in pentobarbitone-anesthetized rats. Electrolytic lesion of the DMV as compared with sham operation and lesions of other brain areas, eg, nucleus reticular gigantocellularis and cuneate nucleus, reduced the basal gastric mucosal blood flow (GMBF) and also the blood flow after ethanol administration. The same operation did not affect the acid secretion either in the basal state or during the ethanol treatment period. Lesions at the caudal half of the DMV produced a bigger depression of GMBF when compared with lesion at the rostral half. In the sham-operated rats, ethanol induced severe hemorrhagic lesions in the gastric glandular mucosa, and this was significantly potentiated by lesions at the DMV, especially in the caudal half. The present findings indicate that acute DMV damage at the caudal half markedly affects the GMBF but not the acid secretion. The action on GMBF may contribute to the aggravation of ethanol-induced gastric damage in rats. These data reinforce the idea that the central vagal pathway, especially the caudal half of the DMV, plays a significant role in the modulation of GMBF, which in turn affects the integrity of gastric mucosal barrier.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_HK
dc.relation.ispartofDigestive Diseases and Sciencesen_HK
dc.subjectDorsal motor nucleus of vagusen_HK
dc.subjectEthanolen_HK
dc.subjectGastric acid secretionen_HK
dc.subjectGastric damageen_HK
dc.subjectGastric mucosal blood flowen_HK
dc.titleRole of dorsal motor nucleus of vagus in gastric function and mucosal damage induced by ethanol in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-2116&volume=40&spage=2312&epage=2316&date=1995&atitle=Role+of+dorsal+motor+nucleus+of+vagus+in+gastric+function+and+mucosal+damage+induced+by+ethanol+in+ratsen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF02063230en_HK
dc.identifier.pmid7587807-
dc.identifier.scopuseid_2-s2.0-0028867766en_HK
dc.identifier.hkuros9285en_HK
dc.identifier.volume40en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2312en_HK
dc.identifier.epage2316en_HK
dc.identifier.isiWOS:A1995TH16300004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridKo, JKS=7402678571en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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