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Article: The role of intracellular pH in the control of adenosine output from red skeletal muscle

TitleThe role of intracellular pH in the control of adenosine output from red skeletal muscle
Authors
KeywordsAdenosine
Hypoxia
Oxygen supply-to-demand ratio
pH
Issue Date1995
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals, 1995, v. 4 n. 3, p. 168-173 How to Cite?
AbstractMore than 30 years ago, it was proposed that adenosine was released from skeletal muscle in response to a decrease in the oxygen supply-to-demand ratio. It has subsequently been confirmed that adenosine is released from red muscles in proportion to the contraction frequency, but the mechanism that controls its release remains controversial. There is no direct evidence for the involvement of oxygen insufficiency in the process, and there is some indirect evidence that it is not involved. On the other hand, there is direct evidence that a decrease in pH, with no change in oxygen supply-to-demand ratio, can stimulate adenosine release, and the amounts of adenosine released are well correlated with the pH change in all situations tested. A direct analysis of the role of hypoxia in adenosine release is therefore urgently needed.
Persistent Identifierhttp://hdl.handle.net/10722/81143
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBallard, HJen_HK
dc.date.accessioned2010-09-06T08:14:19Z-
dc.date.available2010-09-06T08:14:19Z-
dc.date.issued1995en_HK
dc.identifier.citationBiological Signals, 1995, v. 4 n. 3, p. 168-173en_HK
dc.identifier.issn1016-0922en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81143-
dc.description.abstractMore than 30 years ago, it was proposed that adenosine was released from skeletal muscle in response to a decrease in the oxygen supply-to-demand ratio. It has subsequently been confirmed that adenosine is released from red muscles in proportion to the contraction frequency, but the mechanism that controls its release remains controversial. There is no direct evidence for the involvement of oxygen insufficiency in the process, and there is some indirect evidence that it is not involved. On the other hand, there is direct evidence that a decrease in pH, with no change in oxygen supply-to-demand ratio, can stimulate adenosine release, and the amounts of adenosine released are well correlated with the pH change in all situations tested. A direct analysis of the role of hypoxia in adenosine release is therefore urgently needed.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofBiological Signalsen_HK
dc.rightsBiological Signals. Copyright © S Karger AG.en_HK
dc.subjectAdenosineen_HK
dc.subjectHypoxiaen_HK
dc.subjectOxygen supply-to-demand ratioen_HK
dc.subjectpHen_HK
dc.titleThe role of intracellular pH in the control of adenosine output from red skeletal muscleen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1016-0922&volume=4&spage=168&epage=173&date=1995&atitle=The+role+of+intracellular+pH+in+the+control+of+adenosine+output+from+red+skeletal+muscleen_HK
dc.identifier.emailBallard, HJ: ballard@hkucc.hku.hken_HK
dc.identifier.authorityBallard, HJ=rp00367en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8750943-
dc.identifier.scopuseid_2-s2.0-0029563609en_HK
dc.identifier.hkuros11126en_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage168en_HK
dc.identifier.epage173en_HK
dc.identifier.isiWOS:A1995TN13500008-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridBallard, HJ=7005286310en_HK

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