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Article: Regional and diurnal studies of melatonin and melatonin binding sites in the duck gastro-intestinal tract

TitleRegional and diurnal studies of melatonin and melatonin binding sites in the duck gastro-intestinal tract
Authors
KeywordsCaecum
Colon
Diurnal rhythm
Duodenum
Ileum
Jejunum
Melatonin
Melatonin receptors
Oesophagus
Regional distribution
Issue Date1995
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals, 1995, v. 4 n. 4, p. 212-224 How to Cite?
AbstractSince melatonin and putative melatonin receptors can be detected in a variety of peripheral tissues, direct endocrine and paracrine actions of melatonin on the physiological functions of different organ systems in response to internal and external stimuli probably exist. As an extension of our earlier work on the pharmacological characterization of 2-[125I]iodomelatonin binding sites in the duck jejunum, the regional and diurnal variations of melatonin and putative melatonin receptors of different segments of the duck gastro-intestinal tract were studied in an attempt to understand the role of melatonin in the physiology of the digestive system. Although no significant effects of diurnal variation and pinealectomy on the regional distribution of melatonin were observed, significant regional variations of melatonin levels were detected with decreasing levels as follows: colon > oesophagus, caecum > duodenum, jejunum > ileum. The densities of melatonin binding sites showed a significant variation between different intestinal regions at either mid-light or mid-dark, with the following descending order: ileum, jejunum > duodenum, colon > caecum > oesophagus. Analysis of the distribution of melatonin binding sites in the wall of the intestine revealed maximal binding in the mucosa and minimal binding in the muscular layers of the jejunum. Similar results were obtained for other intestinal regions as revealed by autoradiography. No significant changes in the affinities of melatonin binding sites were detected between different regions and tissue layers of the alimentary canal. Moreover, the densities and affinities of melatonin binding sites among different regions of the gut exhibited no significant diurnal variations. The demonstration of regional variations in melatonin levels and the density of melatonin binding sites along the gastro-intestinal tract, with a concentration of the putative melatonin receptors in the mucosal layer, suggests a possible direct action of melatonin in the regulation of fluid/electrolyte transport and nutrient absorption in the gut.
Persistent Identifierhttp://hdl.handle.net/10722/81139
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, PPNen_HK
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorChow, PHen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2010-09-06T08:14:16Z-
dc.date.available2010-09-06T08:14:16Z-
dc.date.issued1995en_HK
dc.identifier.citationBiological Signals, 1995, v. 4 n. 4, p. 212-224en_HK
dc.identifier.issn1016-0922en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81139-
dc.description.abstractSince melatonin and putative melatonin receptors can be detected in a variety of peripheral tissues, direct endocrine and paracrine actions of melatonin on the physiological functions of different organ systems in response to internal and external stimuli probably exist. As an extension of our earlier work on the pharmacological characterization of 2-[125I]iodomelatonin binding sites in the duck jejunum, the regional and diurnal variations of melatonin and putative melatonin receptors of different segments of the duck gastro-intestinal tract were studied in an attempt to understand the role of melatonin in the physiology of the digestive system. Although no significant effects of diurnal variation and pinealectomy on the regional distribution of melatonin were observed, significant regional variations of melatonin levels were detected with decreasing levels as follows: colon > oesophagus, caecum > duodenum, jejunum > ileum. The densities of melatonin binding sites showed a significant variation between different intestinal regions at either mid-light or mid-dark, with the following descending order: ileum, jejunum > duodenum, colon > caecum > oesophagus. Analysis of the distribution of melatonin binding sites in the wall of the intestine revealed maximal binding in the mucosa and minimal binding in the muscular layers of the jejunum. Similar results were obtained for other intestinal regions as revealed by autoradiography. No significant changes in the affinities of melatonin binding sites were detected between different regions and tissue layers of the alimentary canal. Moreover, the densities and affinities of melatonin binding sites among different regions of the gut exhibited no significant diurnal variations. The demonstration of regional variations in melatonin levels and the density of melatonin binding sites along the gastro-intestinal tract, with a concentration of the putative melatonin receptors in the mucosal layer, suggests a possible direct action of melatonin in the regulation of fluid/electrolyte transport and nutrient absorption in the gut.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofBiological Signalsen_HK
dc.rightsBiological Signals. Copyright © S Karger AG.en_HK
dc.subjectCaecumen_HK
dc.subjectColonen_HK
dc.subjectDiurnal rhythmen_HK
dc.subjectDuodenumen_HK
dc.subjectIleumen_HK
dc.subjectJejunumen_HK
dc.subjectMelatoninen_HK
dc.subjectMelatonin receptorsen_HK
dc.subjectOesophagusen_HK
dc.subjectRegional distributionen_HK
dc.titleRegional and diurnal studies of melatonin and melatonin binding sites in the duck gastro-intestinal tracten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1016-0922&volume=4&spage=212&epage=224&date=1995&atitle=Regional+and+diurnal+studies+of+melatonin+and+melatonin+binding+sites+in+the+duck+gastro-intestinal+tracten_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8720688en_HK
dc.identifier.scopuseid_2-s2.0-0029622305en_HK
dc.identifier.hkuros9974en_HK
dc.identifier.volume4en_HK
dc.identifier.issue4en_HK
dc.identifier.spage212en_HK
dc.identifier.epage224en_HK
dc.identifier.isiWOS:A1995TR94200003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLee, PPN=7406119629en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridChow, PH=7202656919en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK

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