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Article: Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease

TitleChinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease
Authors
KeywordsChinese herbs
Dopamine neurons
Neuroprotection
Parkinson's disease
Pharmaceutical therapy
Issue Date2007
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnd
Citation
Cns And Neurological Disorders - Drug Targets, 2007, v. 6 n. 4, p. 273-281 How to Cite?
AbstractParkinson's disease (PD) is a common and debilitating degenerative disease resulting from massive degenerative loss of dopamine neurons, particularly in the substantia nigra. The most classic therapy for PD is levodopa administration, but the efficacy of levodopa treatment declines as the disease progresses. The neuroprotective strategies to rescue nigral dopamine neurons from progressive death are currently being explored, and among them, the Chinese herbs and herbal extracts have shown potential clinical benefit in attenuating the progression of PD in human beings. Growing studies have indicated that a range of Chinese herbs or herbal extracts such as green tea polyphenols or catechins, panax ginseng and ginsenoside, ginkgo biloba and EGb 761, polygonum, triptolide from tripterygium wilfordii hook, polysaccharides from the flowers of nerium indicum, oil from ganoderma lucidum spores, huperzine and stepholidine are able 10 attenuate degeneration of dopamine neurons and sympotoms caused by the neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) in vitro and in vivo conditions. In addition, accumulating data have suggested that Chinese herbs or herbal extracts may promote neuronal survival and neurite growth, and facilitate functional recovery of brain injures by invoking distinct mechanisms that are related to their neuroprotective roles as the antioxidants, dopamine transporter inhibitor, monoamine oxidase inhibitor, free radical scavengers, chelators of harmful metal ions, modulating cell survival genes and signaling, anti-apoptosis activity, and even improving brain blood circulation. New pharmaceutical strategies against PD will hopefully be discovered by understanding the various active entities and valuable combinations that contribute to the biological effects of Chinese herbs and herbal extracts. © 2007 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/81118
ISSN
2015 Impact Factor: 2.188
2015 SCImago Journal Rankings: 0.883
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LWen_HK
dc.contributor.authorWang, YQen_HK
dc.contributor.authorWei, LCen_HK
dc.contributor.authorShi, Men_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-06T08:14:02Z-
dc.date.available2010-09-06T08:14:02Z-
dc.date.issued2007en_HK
dc.identifier.citationCns And Neurological Disorders - Drug Targets, 2007, v. 6 n. 4, p. 273-281en_HK
dc.identifier.issn1871-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81118-
dc.description.abstractParkinson's disease (PD) is a common and debilitating degenerative disease resulting from massive degenerative loss of dopamine neurons, particularly in the substantia nigra. The most classic therapy for PD is levodopa administration, but the efficacy of levodopa treatment declines as the disease progresses. The neuroprotective strategies to rescue nigral dopamine neurons from progressive death are currently being explored, and among them, the Chinese herbs and herbal extracts have shown potential clinical benefit in attenuating the progression of PD in human beings. Growing studies have indicated that a range of Chinese herbs or herbal extracts such as green tea polyphenols or catechins, panax ginseng and ginsenoside, ginkgo biloba and EGb 761, polygonum, triptolide from tripterygium wilfordii hook, polysaccharides from the flowers of nerium indicum, oil from ganoderma lucidum spores, huperzine and stepholidine are able 10 attenuate degeneration of dopamine neurons and sympotoms caused by the neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) in vitro and in vivo conditions. In addition, accumulating data have suggested that Chinese herbs or herbal extracts may promote neuronal survival and neurite growth, and facilitate functional recovery of brain injures by invoking distinct mechanisms that are related to their neuroprotective roles as the antioxidants, dopamine transporter inhibitor, monoamine oxidase inhibitor, free radical scavengers, chelators of harmful metal ions, modulating cell survival genes and signaling, anti-apoptosis activity, and even improving brain blood circulation. New pharmaceutical strategies against PD will hopefully be discovered by understanding the various active entities and valuable combinations that contribute to the biological effects of Chinese herbs and herbal extracts. © 2007 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnden_HK
dc.relation.ispartofCNS and Neurological Disorders - Drug Targetsen_HK
dc.subjectChinese herbsen_HK
dc.subjectDopamine neuronsen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectParkinson's diseaseen_HK
dc.subjectPharmaceutical therapyen_HK
dc.titleChinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/187152707781387288en_HK
dc.identifier.pmid17691984-
dc.identifier.scopuseid_2-s2.0-34547762666en_HK
dc.identifier.hkuros149578en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547762666&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spage273en_HK
dc.identifier.epage281en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChen, LW=15821717100en_HK
dc.identifier.scopusauthoridWang, YQ=13409472800en_HK
dc.identifier.scopusauthoridWei, LC=7402951429en_HK
dc.identifier.scopusauthoridShi, M=36115245300en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

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