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Article: Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro

TitleExcitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro
Authors
KeywordsGlobus pallidus
Histamine
Histamine receptors
Hypothalamic histaminergic projections
Motor control
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
Neuroscience Research, 2005, v. 53 n. 3, p. 288-297 How to Cite?
AbstractPrevious studies have revealed distribution of histaminergic fibers and presence of histamine receptors in globus pallidus (GP). In this study, the brain slice preparation of adult rats was used to examine the effect of histamine on the spontaneous unitary discharge of GP neurons and the underlying receptor mechanism. Ninety-five GP neurons were extracellularly recorded from 42 slices containing the GP, of which 87 (91.6%) were excited by the stimulation of histamine. The histamine-induced excitation was concentration-dependent and persisted in low Ca2+/high Mg2+ medium (n = 9), demonstrating that the action of histamine on the GP neurons was postsynaptic. The excitatory effect of histamine on the GP neurons was not blocked by selective histamine H1 receptor antagonist triprolidine (n = 16) or chlorpheniramine (n = 6), but was effectively suppressed by ranitidine, a highly selective histamine H2 receptor antagonist (n = 21). On the other hand, highly selective histamine H2 receptor agonist dimaprit mimicked the excitatory effect of histamine on the GP neurons (n = 23), while histamine H1 receptor agonists, including 2-pyridylethylamine (n = 22), 2-thiazolyethylamine (n = 9) and betahistine (n = 9), did not cause GP neurons any response. The dimaprit-induced GP neuronal excitation was effectively antagonized by selective histamine H2 receptor antagonist ranitidine (n = 14) but not influenced by selective histamine H1 receptor antagonist triprolidine (n = 12). Moreover, adenylate cyclase (AC) activator forskolin (n = 7) was observed to evoke GP neurons an excitatory response, whereas the histamine-induced excitation was effectively reduced by H-89 (n = 9), a selective and potent inhibitor of protein kinase A (PK A). Finally, it was noted that neurons of both subdivisions of the GP, the internal (GPi, n = 35) and external (GPe, n = 60) segment, showed no differences in their responses to stimulations of the tested histaminergic reagents. These results demonstrated that histamine excited GP (including GPi and GPe) neurons via histamine H2 receptors and H2 receptors linked intracellular G-protein-AC-PKA signaling pathway, suggesting that the hypothalamic histaminergic afferent fibers innervating GP may play an important modulatory role in motor control through its excitatory effect on GP neurons. © 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/81115
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Ken_HK
dc.contributor.authorWang, JJen_HK
dc.contributor.authorWing, HYen_HK
dc.contributor.authorYing, SCen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T08:14:00Z-
dc.date.available2010-09-06T08:14:00Z-
dc.date.issued2005en_HK
dc.identifier.citationNeuroscience Research, 2005, v. 53 n. 3, p. 288-297en_HK
dc.identifier.issn0168-0102en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81115-
dc.description.abstractPrevious studies have revealed distribution of histaminergic fibers and presence of histamine receptors in globus pallidus (GP). In this study, the brain slice preparation of adult rats was used to examine the effect of histamine on the spontaneous unitary discharge of GP neurons and the underlying receptor mechanism. Ninety-five GP neurons were extracellularly recorded from 42 slices containing the GP, of which 87 (91.6%) were excited by the stimulation of histamine. The histamine-induced excitation was concentration-dependent and persisted in low Ca2+/high Mg2+ medium (n = 9), demonstrating that the action of histamine on the GP neurons was postsynaptic. The excitatory effect of histamine on the GP neurons was not blocked by selective histamine H1 receptor antagonist triprolidine (n = 16) or chlorpheniramine (n = 6), but was effectively suppressed by ranitidine, a highly selective histamine H2 receptor antagonist (n = 21). On the other hand, highly selective histamine H2 receptor agonist dimaprit mimicked the excitatory effect of histamine on the GP neurons (n = 23), while histamine H1 receptor agonists, including 2-pyridylethylamine (n = 22), 2-thiazolyethylamine (n = 9) and betahistine (n = 9), did not cause GP neurons any response. The dimaprit-induced GP neuronal excitation was effectively antagonized by selective histamine H2 receptor antagonist ranitidine (n = 14) but not influenced by selective histamine H1 receptor antagonist triprolidine (n = 12). Moreover, adenylate cyclase (AC) activator forskolin (n = 7) was observed to evoke GP neurons an excitatory response, whereas the histamine-induced excitation was effectively reduced by H-89 (n = 9), a selective and potent inhibitor of protein kinase A (PK A). Finally, it was noted that neurons of both subdivisions of the GP, the internal (GPi, n = 35) and external (GPe, n = 60) segment, showed no differences in their responses to stimulations of the tested histaminergic reagents. These results demonstrated that histamine excited GP (including GPi and GPe) neurons via histamine H2 receptors and H2 receptors linked intracellular G-protein-AC-PKA signaling pathway, suggesting that the hypothalamic histaminergic afferent fibers innervating GP may play an important modulatory role in motor control through its excitatory effect on GP neurons. © 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuresen_HK
dc.relation.ispartofNeuroscience Researchen_HK
dc.rightsNeuroscience Research . Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectGlobus pallidusen_HK
dc.subjectHistamineen_HK
dc.subjectHistamine receptorsen_HK
dc.subjectHypothalamic histaminergic projectionsen_HK
dc.subjectMotor controlen_HK
dc.titleExcitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitroen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-0102&volume=53&spage=288&epage=297&date=2005&atitle=Excitatory+effect+of+histamine+on+neuronal+activity+of+rat+globus+pallidus+by+activation+of+H2+receptors+in+vitroen_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2005.07.008en_HK
dc.identifier.pmid16143415en_HK
dc.identifier.scopuseid_2-s2.0-26844445530en_HK
dc.identifier.hkuros115212en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26844445530&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage288en_HK
dc.identifier.epage297en_HK
dc.identifier.isiWOS:000233217100009-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChen, K=24342980800en_HK
dc.identifier.scopusauthoridWang, JJ=9841895000en_HK
dc.identifier.scopusauthoridWing, HY=23471334300en_HK
dc.identifier.scopusauthoridYing, SC=8906075000en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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