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Article: Reactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson's disease

TitleReactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson's disease
Authors
KeywordsCell replacement therapy
Neuroprotection
Parkinson's disease
Reactive astrocytes
Issue Date2005
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdt/index.htm
Citation
Current Drug Targets, 2005, v. 6 n. 7, p. 821-833 How to Cite?
AbstractParkinson' disease (PD) is a most common and debilitating degenerative disease resulted from massive loss of dopamine neurons in the substantia nigra pars compacta, which is characterized by severe motor symptoms of tremor, bradykinesia, rigidity and postural instability. Protection of nigral dopamine neurons from progressive degenerative death and cell replacement of novel dopamine neurons are hopeful strategies against PD in humans. The reactive astrocytes or functional activation of astrocytes abundantly occurred in brain insults including trauma, ischemia, and 6-OHDA or MPTP-treated PD animal models. Although they were traditionally assumed to impede neuronal regeneration by forming glial scars, growing evidence has indicated that reactive astrocytes do offer crucial benefits in functional recovery of brain injuries. The reactive astrocytes can produce various neurotrophic factors for neuron survival, synthesize extracellular substrates for axonal outgrowth and synaptogenesis, act as scavengers for free radical and excess glutamate, and promote neurogenesis of neural progenitor cells in the adult brains. We thereafter hypothesize that reactive astrocytes may also play important roles in the protection of nigral dopamine neurons or transplanted dopamine cells through their neurotrophic functions and active interaction with dopamine neurons or neural progenitor cells. Future approaches deserve to target on neurotrophic functions of reactive astrocytes in the basal ganglia and interventions to facilitate survival and axonal regeneration of dopamine neurons or differentiation of dopamine progenitor cells. Novel pharmaceutical and cell replacement strategies will hopefully be developed by potential manipulation of reactive astrocytes in the basal ganglia in prevention and treatment of Parkinson's disease. © 2005 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/81113
ISSN
2015 Impact Factor: 3.029
2015 SCImago Journal Rankings: 1.211
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LWen_HK
dc.contributor.authorYung, KLen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-06T08:13:59Z-
dc.date.available2010-09-06T08:13:59Z-
dc.date.issued2005en_HK
dc.identifier.citationCurrent Drug Targets, 2005, v. 6 n. 7, p. 821-833en_HK
dc.identifier.issn1389-4501en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81113-
dc.description.abstractParkinson' disease (PD) is a most common and debilitating degenerative disease resulted from massive loss of dopamine neurons in the substantia nigra pars compacta, which is characterized by severe motor symptoms of tremor, bradykinesia, rigidity and postural instability. Protection of nigral dopamine neurons from progressive degenerative death and cell replacement of novel dopamine neurons are hopeful strategies against PD in humans. The reactive astrocytes or functional activation of astrocytes abundantly occurred in brain insults including trauma, ischemia, and 6-OHDA or MPTP-treated PD animal models. Although they were traditionally assumed to impede neuronal regeneration by forming glial scars, growing evidence has indicated that reactive astrocytes do offer crucial benefits in functional recovery of brain injuries. The reactive astrocytes can produce various neurotrophic factors for neuron survival, synthesize extracellular substrates for axonal outgrowth and synaptogenesis, act as scavengers for free radical and excess glutamate, and promote neurogenesis of neural progenitor cells in the adult brains. We thereafter hypothesize that reactive astrocytes may also play important roles in the protection of nigral dopamine neurons or transplanted dopamine cells through their neurotrophic functions and active interaction with dopamine neurons or neural progenitor cells. Future approaches deserve to target on neurotrophic functions of reactive astrocytes in the basal ganglia and interventions to facilitate survival and axonal regeneration of dopamine neurons or differentiation of dopamine progenitor cells. Novel pharmaceutical and cell replacement strategies will hopefully be developed by potential manipulation of reactive astrocytes in the basal ganglia in prevention and treatment of Parkinson's disease. © 2005 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdt/index.htmen_HK
dc.relation.ispartofCurrent Drug Targetsen_HK
dc.subjectCell replacement therapyen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectParkinson's diseaseen_HK
dc.subjectReactive astrocytesen_HK
dc.titleReactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1389-4501&volume=6&issue=7&spage=821&epage=833&date=2005&atitle=Reactive+astrocytes+as+potential+manipulation+targets+in+novel+cell+replacement+therapy+of+Parkinson’s+diseaseen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/138945005774574506en_HK
dc.identifier.pmid16305461-
dc.identifier.scopuseid_2-s2.0-26944461180en_HK
dc.identifier.hkuros121695en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26944461180&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue7en_HK
dc.identifier.spage821en_HK
dc.identifier.epage833en_HK
dc.identifier.isiWOS:000232478300014-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChen, LW=7409444941en_HK
dc.identifier.scopusauthoridYung, KL=36840202100en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.citeulike368859-

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