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Article: Spontaneous activity and barosensitivity of the barosensitive neurons in the rostral ventrolateral medulla of hypertensive rats induced by transection of aortic depressor nerves

TitleSpontaneous activity and barosensitivity of the barosensitive neurons in the rostral ventrolateral medulla of hypertensive rats induced by transection of aortic depressor nerves
Authors
KeywordsAortic depressor nerve
Barosensitive neuron
Barosensitivity
Coefficient of variation
Firing rate
Neurogenic hypertension
Rostral ventrolateral medulla
Skewness
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1998, v. 813 n. 2, p. 262-267 How to Cite?
AbstractIn order to determine the role of the rostral ventrolateral medulla (RVLM) in the development of neurogenic hypertension, the aortic depressor nerves of rats were transected (tADN) to produce neurogenic hypertension. The rate and pattern of firing of the barosensitive RVLM neurons of the treated rats were studied. In neurogenic hypertensive rats, the RVLM barosensitive neurons exhibited a faster firing rate and a shorter interspike interval (ISI) than the corresponding values of the control and sham groups, indicating an enhanced spontaneous activity of these neurons in the hypertensive rats. The coefficient of variation (cv) and skewness (sk) of the ISI histogram, parameters reflecting the regularity of neuronal firing, were smaller in neurogenic hypertensive than in the control and sham-operated rats. Following tADN, the responsiveness of these neurons to blood pressure changes was attenuated, suggesting a reduced intrinsic barosensitivity of neurons and/or a reduced baroreceptor input. The increase in spontaneous activity and firing regularity of RVLM barosensitive neurons imply an enhancement in the efficacy of outflow from these neurons. The increased efficacy of the outflow from the RVLM barosensitive neurons and the resetting of the baroreflex may contribute to the genesis of neurogenic hypertension.
Persistent Identifierhttp://hdl.handle.net/10722/81111
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHan, YMYen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorLo, KSen_HK
dc.contributor.authorWong, TMen_HK
dc.date.accessioned2010-09-06T08:13:57Z-
dc.date.available2010-09-06T08:13:57Z-
dc.date.issued1998en_HK
dc.identifier.citationBrain Research, 1998, v. 813 n. 2, p. 262-267en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81111-
dc.description.abstractIn order to determine the role of the rostral ventrolateral medulla (RVLM) in the development of neurogenic hypertension, the aortic depressor nerves of rats were transected (tADN) to produce neurogenic hypertension. The rate and pattern of firing of the barosensitive RVLM neurons of the treated rats were studied. In neurogenic hypertensive rats, the RVLM barosensitive neurons exhibited a faster firing rate and a shorter interspike interval (ISI) than the corresponding values of the control and sham groups, indicating an enhanced spontaneous activity of these neurons in the hypertensive rats. The coefficient of variation (cv) and skewness (sk) of the ISI histogram, parameters reflecting the regularity of neuronal firing, were smaller in neurogenic hypertensive than in the control and sham-operated rats. Following tADN, the responsiveness of these neurons to blood pressure changes was attenuated, suggesting a reduced intrinsic barosensitivity of neurons and/or a reduced baroreceptor input. The increase in spontaneous activity and firing regularity of RVLM barosensitive neurons imply an enhancement in the efficacy of outflow from these neurons. The increased efficacy of the outflow from the RVLM barosensitive neurons and the resetting of the baroreflex may contribute to the genesis of neurogenic hypertension.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subjectAortic depressor nerveen_HK
dc.subjectBarosensitive neuronen_HK
dc.subjectBarosensitivityen_HK
dc.subjectCoefficient of variationen_HK
dc.subjectFiring rateen_HK
dc.subjectNeurogenic hypertensionen_HK
dc.subjectRostral ventrolateral medullaen_HK
dc.subjectSkewnessen_HK
dc.titleSpontaneous activity and barosensitivity of the barosensitive neurons in the rostral ventrolateral medulla of hypertensive rats induced by transection of aortic depressor nervesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=813&issue=2&spage=262&epage=267&date=1998&atitle=Spontaneous+activity+and+barosensitivity+of+the+barosensitive+neurons+in+the+rostral+ventrolateral+medulla+of+hypertensive+rats+induced+by+transection+of+aortic+depressor+nervesen_HK
dc.identifier.emailChan, YS: yschan@hku.hken_HK
dc.identifier.emailLo, KS: kingslo@hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityLo, KS=rp00270en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0006-8993(98)00963-9en_HK
dc.identifier.pmid9838155-
dc.identifier.scopuseid_2-s2.0-0032495202en_HK
dc.identifier.hkuros44351en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032495202&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume813en_HK
dc.identifier.issue2en_HK
dc.identifier.spage262en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:000077234900004-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHan, YMY=55489288500en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridLo, KS=20135001700en_HK
dc.identifier.scopusauthoridWong, TM=7403531434en_HK

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