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Article: The effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: Measurement by solution-hybridization RNase protection assay

TitleThe effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: Measurement by solution-hybridization RNase protection assay
Authors
KeywordsAging
Dopamine receptors
Haloperidol
Preproenkephalin mRNA
Preprotachykinin mRNA
Protection assay
Solution hybridization-RNase
Striatum
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1998, v. 246 n. 1, p. 33-36 How to Cite?
AbstractThe preproenkephalin (PPeK) and preprotachykinin (PPT) mRNA contents in 3-, 10- and 23-month-old rats in the striatum were measured by solution hybridization-RNase protection assay after 3 weeks of haloperidol injection. Haloperidol increased striatal PPek mRNA. There was no age-related difference in the response of striatal PPeK mRNA to chronic haloperidol treatment. The PPT mRNA decreased by 21% after the haloperidol treatment in young rats only. Meanwhile, age decreased the PPT mRNA by 27 and 24% in 10- and 23-month-old rats, respectively. It is concluded that there is a difference in the effects of aging on the response of PPek and PPT mRNA contents to haloperidol and that the loss of PPT mRNA response in 10- and 23-month-old rats might be due to the change of dopamine system of the striatum in these rats.
Persistent Identifierhttp://hdl.handle.net/10722/81105
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, SMen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-06T08:13:53Z-
dc.date.available2010-09-06T08:13:53Z-
dc.date.issued1998en_HK
dc.identifier.citationNeuroscience Letters, 1998, v. 246 n. 1, p. 33-36en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81105-
dc.description.abstractThe preproenkephalin (PPeK) and preprotachykinin (PPT) mRNA contents in 3-, 10- and 23-month-old rats in the striatum were measured by solution hybridization-RNase protection assay after 3 weeks of haloperidol injection. Haloperidol increased striatal PPek mRNA. There was no age-related difference in the response of striatal PPeK mRNA to chronic haloperidol treatment. The PPT mRNA decreased by 21% after the haloperidol treatment in young rats only. Meanwhile, age decreased the PPT mRNA by 27 and 24% in 10- and 23-month-old rats, respectively. It is concluded that there is a difference in the effects of aging on the response of PPek and PPT mRNA contents to haloperidol and that the loss of PPT mRNA response in 10- and 23-month-old rats might be due to the change of dopamine system of the striatum in these rats.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAgingen_HK
dc.subjectDopamine receptorsen_HK
dc.subjectHaloperidolen_HK
dc.subjectPreproenkephalin mRNAen_HK
dc.subjectPreprotachykinin mRNAen_HK
dc.subjectProtection assayen_HK
dc.subjectSolution hybridization-RNaseen_HK
dc.subjectStriatumen_HK
dc.titleThe effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: Measurement by solution-hybridization RNase protection assayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=246&spage=33&epage=36&date=1998&atitle=The+effect+of+aging+on+the+response+of+striatal+preproenkephalin+and+preprotachykinin+mRNA+contents+to+chronic+haloperidol+treatment+in+rats:+measurement+by+solution-hybridization+RNase+protection+assayen_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3940(98)00202-Xen_HK
dc.identifier.pmid9622201-
dc.identifier.scopuseid_2-s2.0-0032540477en_HK
dc.identifier.hkuros36673en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032540477&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume246en_HK
dc.identifier.issue1en_HK
dc.identifier.spage33en_HK
dc.identifier.epage36en_HK
dc.identifier.isiWOS:000073389700009-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLau, SM=16740565000en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

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