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Article: Frequency tuning and firing pattern properties of auditory thalamic neurons: An in vivo intracellular recording from the guinea pig

TitleFrequency tuning and firing pattern properties of auditory thalamic neurons: An in vivo intracellular recording from the guinea pig
Authors
Keywordsexcitatory postsynaptic potential
firing pattern
frequency tuning
inhibitory postsynaptic potential
medial geniculate body
resting membrane potential
single-units
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2008, v. 151 n. 1, p. 293-302 How to Cite?
AbstractWe investigated the firing pattern and frequency tuning properties of medial geniculate body (MGB) neurons, through in vivo intracellular recordings in anesthetized guinea pigs. Twenty-two of the 25 physiological characterized neurons were anatomically identified. Ten neurons were located in the ventral division of the medial geniculate body (MGv) (seven in pars ovoidea (OV) and three in the pars lateralis (LV)). Eight were located in the dorsal division (MGd), and four in the medial division (MGm). OV neurons showed a uniform, phasic ON response with high frequency selectivity. Functionally, they are interpreted as relaying spectral information with high reliability. LV neurons exhibited various patterns: phasic, tonic and excitatory postsynaptic potentials (EPSP) with a spike train. These high magnitude EPSPs are proposed to convey temporal information of the auditory signals with more encoding power. MGd neurons had relatively low best frequencies while MGm neurons had high intensity threshold, broader frequency selectivity, and a tonic response pattern. Tonic firing is likely to impose a strong impact onto wide cortical area and amygdala. When hyperpolarized with current injection, MGB neurons evoked low-threshold calcium spikes. Distinct change in these spike numbers was observed among MGv and MGd neurons as compared with MGm neurons, implying their differential roles. MGm neurons are more modulatory in nature, while the long lasting bursts of low-threshold calcium spikes observed in MGv and MGd neurons probably participate in propagating the sleep oscillations. © 2008 IBRO.
Persistent Identifierhttp://hdl.handle.net/10722/81104
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorYu, YQen_HK
dc.contributor.authorLiu, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-09-06T08:13:52Z-
dc.date.available2010-09-06T08:13:52Z-
dc.date.issued2008en_HK
dc.identifier.citationNeuroscience, 2008, v. 151 n. 1, p. 293-302en_HK
dc.identifier.issn0306-4522en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81104-
dc.description.abstractWe investigated the firing pattern and frequency tuning properties of medial geniculate body (MGB) neurons, through in vivo intracellular recordings in anesthetized guinea pigs. Twenty-two of the 25 physiological characterized neurons were anatomically identified. Ten neurons were located in the ventral division of the medial geniculate body (MGv) (seven in pars ovoidea (OV) and three in the pars lateralis (LV)). Eight were located in the dorsal division (MGd), and four in the medial division (MGm). OV neurons showed a uniform, phasic ON response with high frequency selectivity. Functionally, they are interpreted as relaying spectral information with high reliability. LV neurons exhibited various patterns: phasic, tonic and excitatory postsynaptic potentials (EPSP) with a spike train. These high magnitude EPSPs are proposed to convey temporal information of the auditory signals with more encoding power. MGd neurons had relatively low best frequencies while MGm neurons had high intensity threshold, broader frequency selectivity, and a tonic response pattern. Tonic firing is likely to impose a strong impact onto wide cortical area and amygdala. When hyperpolarized with current injection, MGB neurons evoked low-threshold calcium spikes. Distinct change in these spike numbers was observed among MGv and MGd neurons as compared with MGm neurons, implying their differential roles. MGm neurons are more modulatory in nature, while the long lasting bursts of low-threshold calcium spikes observed in MGv and MGd neurons probably participate in propagating the sleep oscillations. © 2008 IBRO.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_HK
dc.relation.ispartofNeuroscienceen_HK
dc.rightsNeuroscience. Copyright © Elsevier BV.en_HK
dc.subjectexcitatory postsynaptic potentialen_HK
dc.subjectfiring patternen_HK
dc.subjectfrequency tuningen_HK
dc.subjectinhibitory postsynaptic potentialen_HK
dc.subjectmedial geniculate bodyen_HK
dc.subjectresting membrane potentialen_HK
dc.subjectsingle-unitsen_HK
dc.titleFrequency tuning and firing pattern properties of auditory thalamic neurons: An in vivo intracellular recording from the guinea pigen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-4522&volume=151&spage=293&epage=302&date=2008&atitle=Frequency+tuning+and+firing+pattern+properties+of+auditory+thalamic+neurons:+An+in+vivo+intracellular+recording+from+the+guinea+pig.en_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroscience.2007.09.082en_HK
dc.identifier.pmid18082967en_HK
dc.identifier.scopuseid_2-s2.0-38049044076en_HK
dc.identifier.hkuros149581en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38049044076&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume151en_HK
dc.identifier.issue1en_HK
dc.identifier.spage293en_HK
dc.identifier.epage302en_HK
dc.identifier.isiWOS:000252608800027-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhang, Z=23053543300en_HK
dc.identifier.scopusauthoridYu, YQ=7406253532en_HK
dc.identifier.scopusauthoridLiu, CH=54970584700en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

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