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Article: Autoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymis

TitleAutoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymis
Authors
Keywordsautoradiography
constant light
corpus epididymidis
melatonin receptor
rhythm
testosterone
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1996, v. 59 n. 14, p. 1165-1174 How to Cite?
AbstractAutoradiographic study was conducted to localize 2-[ 125I]iodomelatonin binding in the rat epididymis. In the peripubertal (6 weeks old), postpubertal (8 weeks old) and adult (3 months old) rats, intense specific 2-[ 125I]iodomelatonin labelling of the corpus epididymidis was observed. The intensity of 2-[ 125I]iodomelatonin binding in the distal epididymal segment was significantly decreased in orchidectomized rats but the effect could be reversed with testosterone replacement. The intensity of 2-[ 125I]iodomelatonin binding in the distal rat epididymal segment did not show any diurnal rhythmicity when mid-light period and mid-dark period levels were compared, and was unaffected by constant lighting. Our data suggest androgen-dependent expression of 2-[ 125I]iodomelatonin binding sites, independent of light-induced changes in circulating melatonin, in the rat corpus epididymidis. A novel role of melatonin and its receptor in the regulation of the functions of rat corpus epididymidis is strongly implicated.
Persistent Identifierhttp://hdl.handle.net/10722/81100
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShiu, SYWen_HK
dc.contributor.authorChow, PHen_HK
dc.contributor.authorYu, ZHen_HK
dc.contributor.authorTang, Fen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2010-09-06T08:13:49Z-
dc.date.available2010-09-06T08:13:49Z-
dc.date.issued1996en_HK
dc.identifier.citationLife Sciences, 1996, v. 59 n. 14, p. 1165-1174en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/81100-
dc.description.abstractAutoradiographic study was conducted to localize 2-[ 125I]iodomelatonin binding in the rat epididymis. In the peripubertal (6 weeks old), postpubertal (8 weeks old) and adult (3 months old) rats, intense specific 2-[ 125I]iodomelatonin labelling of the corpus epididymidis was observed. The intensity of 2-[ 125I]iodomelatonin binding in the distal epididymal segment was significantly decreased in orchidectomized rats but the effect could be reversed with testosterone replacement. The intensity of 2-[ 125I]iodomelatonin binding in the distal rat epididymal segment did not show any diurnal rhythmicity when mid-light period and mid-dark period levels were compared, and was unaffected by constant lighting. Our data suggest androgen-dependent expression of 2-[ 125I]iodomelatonin binding sites, independent of light-induced changes in circulating melatonin, in the rat corpus epididymidis. A novel role of melatonin and its receptor in the regulation of the functions of rat corpus epididymidis is strongly implicated.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectautoradiographyen_HK
dc.subjectconstant lighten_HK
dc.subjectcorpus epididymidisen_HK
dc.subjectmelatonin receptoren_HK
dc.subjectrhythmen_HK
dc.subjecttestosteroneen_HK
dc.titleAutoradiographic distribution and physiological regulation of 2-[125I]iodomelatonin binding in rat epididymisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=59&spage=1165&epage=1174&date=1996&atitle=Autoradiographic+distribution+and+physiological+regulation+of+2-[125I]iodomelatonin+binding+in+rat+epididymisen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0024-3205(96)00434-1en_HK
dc.identifier.pmid8831804-
dc.identifier.scopuseid_2-s2.0-0030606799en_HK
dc.identifier.hkuros20910en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030606799&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue14en_HK
dc.identifier.spage1165en_HK
dc.identifier.epage1174en_HK
dc.identifier.isiWOS:A1996VE89900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK
dc.identifier.scopusauthoridChow, PH=7202656919en_HK
dc.identifier.scopusauthoridYu, ZH=7404346841en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK

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