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Article: Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery

TitleHydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery
Authors
KeywordsEndothelium
Endothelium-derived hyperpolarizing factor
Hydrogen peroxide
Membrane potential
Smooth muscle
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2005, v. 513 n. 3, p. 219-224 How to Cite?
AbstractThis study was designed to determine whether or not endothelium-dependent hyperpolarizations evoked by acetylcholine in the isolated guinea-pig carotid artery involve hydrogen peroxide. Membrane potential was recorded in the vascular smooth muscle cells of that artery. Under control conditions, acetylcholine induced endothelium-dependent hyperpolarization of the vascular smooth muscle cells which was not affected by the presence of catalase, superoxide dismutase or their combination. Neither the superoxide dismutase mimetic, tiron nor the thiol-reducing agent N-acetyl-l-cysteine modified the hyperpolarization evoked by 0.1 μM acetylcholine but each produced a partial and significant inhibition of the hyperpolarization induced by 1 μM acetylcholine. Neither 10 nor 100 μM hydrogen peroxide influenced the resting membrane potential of the smooth muscle cells and the higher concentration did not significantly influence the hyperpolarization elicited by acetylcholine. These data indicate that, in the guinea-pig isolated carotid artery, hydrogen peroxide is unlikely to contribute to the endothelium-dependent hyperpolarization evoked by acetylcholine. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80330
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGluais, Pen_HK
dc.contributor.authorEdwards, Gen_HK
dc.contributor.authorWeston, AHen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorFélétou, Men_HK
dc.date.accessioned2010-09-06T08:05:07Z-
dc.date.available2010-09-06T08:05:07Z-
dc.date.issued2005en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2005, v. 513 n. 3, p. 219-224en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80330-
dc.description.abstractThis study was designed to determine whether or not endothelium-dependent hyperpolarizations evoked by acetylcholine in the isolated guinea-pig carotid artery involve hydrogen peroxide. Membrane potential was recorded in the vascular smooth muscle cells of that artery. Under control conditions, acetylcholine induced endothelium-dependent hyperpolarization of the vascular smooth muscle cells which was not affected by the presence of catalase, superoxide dismutase or their combination. Neither the superoxide dismutase mimetic, tiron nor the thiol-reducing agent N-acetyl-l-cysteine modified the hyperpolarization evoked by 0.1 μM acetylcholine but each produced a partial and significant inhibition of the hyperpolarization induced by 1 μM acetylcholine. Neither 10 nor 100 μM hydrogen peroxide influenced the resting membrane potential of the smooth muscle cells and the higher concentration did not significantly influence the hyperpolarization elicited by acetylcholine. These data indicate that, in the guinea-pig isolated carotid artery, hydrogen peroxide is unlikely to contribute to the endothelium-dependent hyperpolarization evoked by acetylcholine. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectEndotheliumen_HK
dc.subjectEndothelium-derived hyperpolarizing factoren_HK
dc.subjectHydrogen peroxideen_HK
dc.subjectMembrane potentialen_HK
dc.subjectSmooth muscleen_HK
dc.titleHydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid arteryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=513&spage=219&epage=224&date=2005&atitle=Hydrogen+peroxide+and+endothelium-dependent+hyperpolarization+in+the+guinea-pig+carotid+arteryen_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2005.02.042en_HK
dc.identifier.pmid15862803-
dc.identifier.scopuseid_2-s2.0-18144415479en_HK
dc.identifier.hkuros98397en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18144415479&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume513en_HK
dc.identifier.issue3en_HK
dc.identifier.spage219en_HK
dc.identifier.epage224en_HK
dc.identifier.isiWOS:000229588500005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridGluais, P=6602456462en_HK
dc.identifier.scopusauthoridEdwards, G=7402317535en_HK
dc.identifier.scopusauthoridWeston, AH=7102913361en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridFélétou, M=7006461826en_HK

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