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Article: Heparin increases human gastric carcinoma cell growth

TitleHeparin increases human gastric carcinoma cell growth
Authors
Keywordsc-Myc
Cyclooxygenase
Epidermal growth factor receptor
Gastric cancer
Heparin
Issue Date2006
PublisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/
Citation
Anticancer Research, 2006, v. 26 n. 1 A, p. 439-443 How to Cite?
AbstractBackground: Heparin has been widely used to prevent cancer-associated thromboembolism in cancer patients. Recent evidence reveals that heparin could modulate cell proliferation in the stomach. The effect of heparin on gastric cancer growth, however, is unknown. The effect of heparin on the proliferation of a human gastric adenocarcinoma cell line, BGC-823, was investigated. Materials and Methods: Cell proliferation was assessed by [3H]- thymidine incorporation. The expressions of several growth-related genes were determined by RT-PCR and Western blot. Results: Heparin significantly increased cell proliferation in BGC-823 cancer cells by 15.5% at the dose of 0.2 μg/ml. Heparin also up-regulated c-Myc protein expression by 14.4%. In contrast, mRNA and protein levels of epidermal growth factor receptor (EGFR) were, respectively, down-regulated by 12.7% and 8.2% with no effect on cyclooxygenase-2 mRNA or protein expression. Conclusion: Our results suggest that heparin can promote the proliferation and up-regulation of c-Myc protein expression in gastric cancer cells.
Persistent Identifierhttp://hdl.handle.net/10722/80329
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorYe, YNen_HK
dc.contributor.authorWong, HPSen_HK
dc.contributor.authorHuang, FYen_HK
dc.contributor.authorHui, MKCen_HK
dc.contributor.authorLam, EKYen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:05:06Z-
dc.date.available2010-09-06T08:05:06Z-
dc.date.issued2006en_HK
dc.identifier.citationAnticancer Research, 2006, v. 26 n. 1 A, p. 439-443en_HK
dc.identifier.issn0250-7005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80329-
dc.description.abstractBackground: Heparin has been widely used to prevent cancer-associated thromboembolism in cancer patients. Recent evidence reveals that heparin could modulate cell proliferation in the stomach. The effect of heparin on gastric cancer growth, however, is unknown. The effect of heparin on the proliferation of a human gastric adenocarcinoma cell line, BGC-823, was investigated. Materials and Methods: Cell proliferation was assessed by [3H]- thymidine incorporation. The expressions of several growth-related genes were determined by RT-PCR and Western blot. Results: Heparin significantly increased cell proliferation in BGC-823 cancer cells by 15.5% at the dose of 0.2 μg/ml. Heparin also up-regulated c-Myc protein expression by 14.4%. In contrast, mRNA and protein levels of epidermal growth factor receptor (EGFR) were, respectively, down-regulated by 12.7% and 8.2% with no effect on cyclooxygenase-2 mRNA or protein expression. Conclusion: Our results suggest that heparin can promote the proliferation and up-regulation of c-Myc protein expression in gastric cancer cells.en_HK
dc.languageengen_HK
dc.publisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/en_HK
dc.relation.ispartofAnticancer Researchen_HK
dc.subjectc-Mycen_HK
dc.subjectCyclooxygenaseen_HK
dc.subjectEpidermal growth factor receptoren_HK
dc.subjectGastric canceren_HK
dc.subjectHeparinen_HK
dc.titleHeparin increases human gastric carcinoma cell growthen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0250-7005&volume=26&spage=439&epage=443&date=2006&atitle=Heparin+increases+human+gastric+carcinoma+cell+growthen_HK
dc.identifier.emailWong, HPS:hpswong@hkusua.hku.hken_HK
dc.identifier.authorityWong, HPS=rp00808en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16475731en_HK
dc.identifier.scopuseid_2-s2.0-32144440130en_HK
dc.identifier.hkuros157310en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32144440130&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue1 Aen_HK
dc.identifier.spage439en_HK
dc.identifier.epage443en_HK
dc.identifier.isiWOS:000235103800060-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridWu, WKK=8507784700en_HK
dc.identifier.scopusauthoridShin, VY=7003491170en_HK
dc.identifier.scopusauthoridYe, YN=7401627402en_HK
dc.identifier.scopusauthoridWong, HPS=8644138100en_HK
dc.identifier.scopusauthoridHuang, FY=8644138400en_HK
dc.identifier.scopusauthoridHui, MKC=8644138500en_HK
dc.identifier.scopusauthoridLam, EKY=8644138600en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK

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