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Article: Detrimental vascular effects of lysophosphatidyl-choline is limited by other phospholipid components of low-density lipoprotein

TitleDetrimental vascular effects of lysophosphatidyl-choline is limited by other phospholipid components of low-density lipoprotein
Authors
KeywordsLysophosphatidylcholine
Phosphatidylcholine
Porcine coronary artery
Sphingomyelin
Vascular relaxation
Issue Date2003
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2003, v. 250 n. 1-2, p. 159-166 How to Cite?
AbstractCurrent consensus suggests that lysophosphatidylcholine is the major detrimental factor in oxidized low-density lipoprotein that may contribute to the alterations of vasomotor responses associated with atherosclerosis. This study investigated the influences of lysophosphatidylcholine and major lipid components in oxidized low-density lipoprotein on vascular relaxation. We also determine if there was any interaction between these phospholipid components on relaxation. Porcine coronary artery rings were incubated with lysophosphatidylcholine, phosphatidylcholine or sphingomyelin. After contraction by the thromboxane A 2 mimetic U46619, rings were relaxed with bradykinin and calcium ionophore A23187. Lysophosphatidylcholine with a higher proportion of stearoyl-lysophosphatidylcholine to palmitoyl-lysophosphatidylcholine ratio caused greater reduction of relaxational responses. While phosphatidylcholine and sphingomyelin had no effect on vascular relaxation, they reduced the ability of lysophosphatidylcholine to impair vascular relaxation. Our results thus suggested that the effectiveness of oxidized low-density lipoprotein at inhibiting vasodilatory responses may be determined by the relative proportion of different types of lysophosphatidylcholine as well as the amount of other phospholipid components: phosphatidylcholine and sphingomyelin.
Persistent Identifierhttp://hdl.handle.net/10722/80327
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorHuang, Men_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:05:05Z-
dc.date.available2010-09-06T08:05:05Z-
dc.date.issued2003en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2003, v. 250 n. 1-2, p. 159-166en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80327-
dc.description.abstractCurrent consensus suggests that lysophosphatidylcholine is the major detrimental factor in oxidized low-density lipoprotein that may contribute to the alterations of vasomotor responses associated with atherosclerosis. This study investigated the influences of lysophosphatidylcholine and major lipid components in oxidized low-density lipoprotein on vascular relaxation. We also determine if there was any interaction between these phospholipid components on relaxation. Porcine coronary artery rings were incubated with lysophosphatidylcholine, phosphatidylcholine or sphingomyelin. After contraction by the thromboxane A 2 mimetic U46619, rings were relaxed with bradykinin and calcium ionophore A23187. Lysophosphatidylcholine with a higher proportion of stearoyl-lysophosphatidylcholine to palmitoyl-lysophosphatidylcholine ratio caused greater reduction of relaxational responses. While phosphatidylcholine and sphingomyelin had no effect on vascular relaxation, they reduced the ability of lysophosphatidylcholine to impair vascular relaxation. Our results thus suggested that the effectiveness of oxidized low-density lipoprotein at inhibiting vasodilatory responses may be determined by the relative proportion of different types of lysophosphatidylcholine as well as the amount of other phospholipid components: phosphatidylcholine and sphingomyelin.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and Cellular Biochemistryen_HK
dc.subjectLysophosphatidylcholineen_HK
dc.subjectPhosphatidylcholineen_HK
dc.subjectPorcine coronary arteryen_HK
dc.subjectSphingomyelinen_HK
dc.subjectVascular relaxationen_HK
dc.titleDetrimental vascular effects of lysophosphatidyl-choline is limited by other phospholipid components of low-density lipoproteinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8177&volume=250&spage=159&epage=166&date=2003&atitle=Detrimental+vascular+effects+of+lysophosphatidyl-choline+is+limited+by+other+phospholipid+components+of+low-density+lipoproteinen_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1024913721398en_HK
dc.identifier.pmid12962154-
dc.identifier.scopuseid_2-s2.0-0041383923en_HK
dc.identifier.hkuros80446en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041383923&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume250en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage159en_HK
dc.identifier.epage166en_HK
dc.identifier.isiWOS:000184420500018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridHuang, M=55198346200en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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