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Article: Acute impairment of relaxation by low levels of testosterone in porcine coronary arteries

TitleAcute impairment of relaxation by low levels of testosterone in porcine coronary arteries
Authors
KeywordsArteries
Coronary circulation
Hormones
Receptors
Vasodilation
Issue Date2000
PublisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org
Citation
Cardiovascular Research, 2000, v. 45 n. 4, p. 1010-1018 How to Cite?
AbstractObjectives: While there are many suggested reasons for the marked gender bias in cardiovascular events, much of the available data indicate that circulating estrogens are cardioprotective. The possibility that endogenous androgens may be detrimental to the cardiovascular system has received relatively less attention. We investigated the short-term modulatory effects of various concentrations of testosterone on vascular function in isolated porcine coronary artery rings. Results: The higher concentrations (>1 μM) of testosterone relaxed U46619-contracted coronary artery rings in an endothelium-independent manner. This direct effect was insensitive to the testosterone receptor antagonists, flutamide and cyproterone acetate. Short- term exposure (20 min) to low levels of testosterone (1-100 nM), which were ineffective on their own on vascular function, significantly diminished relaxation to bradykinin and calcium ionophore A23187 but not those produced by levcromakalim and sodium nitroprusside. The inhibitory effect observed with 1 nM testosterone was only partially reversed by flutamide and cyproterone acetate and unaltered in the presence of actinomycin D and cycloheximide. Conclusions: These results demonstrate that acute treatment with testosterone, at concentrations that have no effect on their own, reduces vasorelaxation. Furthermore, they suggest that this modulatory action may be in part independent of the classical testosterone receptor since it was not completely sensitive to the anti-androgens and was not inhibited by the transcriptional and translational inhibitors. These findings support the postulation that testosterone may have unfavorable influences on vascular function. (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/80321
ISSN
2015 Impact Factor: 5.465
2015 SCImago Journal Rankings: 2.897
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTeoh, Hen_HK
dc.contributor.authorQuan, Aen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:05:01Z-
dc.date.available2010-09-06T08:05:01Z-
dc.date.issued2000en_HK
dc.identifier.citationCardiovascular Research, 2000, v. 45 n. 4, p. 1010-1018en_HK
dc.identifier.issn0008-6363en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80321-
dc.description.abstractObjectives: While there are many suggested reasons for the marked gender bias in cardiovascular events, much of the available data indicate that circulating estrogens are cardioprotective. The possibility that endogenous androgens may be detrimental to the cardiovascular system has received relatively less attention. We investigated the short-term modulatory effects of various concentrations of testosterone on vascular function in isolated porcine coronary artery rings. Results: The higher concentrations (>1 μM) of testosterone relaxed U46619-contracted coronary artery rings in an endothelium-independent manner. This direct effect was insensitive to the testosterone receptor antagonists, flutamide and cyproterone acetate. Short- term exposure (20 min) to low levels of testosterone (1-100 nM), which were ineffective on their own on vascular function, significantly diminished relaxation to bradykinin and calcium ionophore A23187 but not those produced by levcromakalim and sodium nitroprusside. The inhibitory effect observed with 1 nM testosterone was only partially reversed by flutamide and cyproterone acetate and unaltered in the presence of actinomycin D and cycloheximide. Conclusions: These results demonstrate that acute treatment with testosterone, at concentrations that have no effect on their own, reduces vasorelaxation. Furthermore, they suggest that this modulatory action may be in part independent of the classical testosterone receptor since it was not completely sensitive to the anti-androgens and was not inhibited by the transcriptional and translational inhibitors. These findings support the postulation that testosterone may have unfavorable influences on vascular function. (C) 2000 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.orgen_HK
dc.relation.ispartofCardiovascular Researchen_HK
dc.rightsCardiovascular Research. Copyright © Elsevier BV.en_HK
dc.subjectArteriesen_HK
dc.subjectCoronary circulationen_HK
dc.subjectHormonesen_HK
dc.subjectReceptorsen_HK
dc.subjectVasodilationen_HK
dc.titleAcute impairment of relaxation by low levels of testosterone in porcine coronary arteriesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-6363&volume=45&spage=1010&epage=1018&date=2000&atitle=Acute+impairment+of+relaxation+by+low+levels+of+testosterone+in+porcine+coronary+arteriesen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S0008-6363(99)00398-3en_HK
dc.identifier.pmid10728427en_HK
dc.identifier.scopuseid_2-s2.0-0033965819en_HK
dc.identifier.hkuros50194en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033965819&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1010en_HK
dc.identifier.epage1018en_HK
dc.identifier.isiWOS:000085566800024-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTeoh, H=7003816542en_HK
dc.identifier.scopusauthoridQuan, A=7006871453en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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