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Article: Contents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza)

TitleContents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza)
Authors
KeywordsHigh pressure liquid chromatography
Magnesium tanshinoate B (MTB)
Salvia miltiorrhiza
Issue Date2002
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2002, v. 23 n. 12, p. 1163-1168 How to Cite?
AbstractAIM: To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations. METHODS: Commercially available danshen crude drugs from different sources, as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected. The composition of these danshen samples was analyzed using HPLC. Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone II A, and cryptotanshinone were determined. In some of these samples, the content of MTB was further confirmed by liquid chromatography- tandem mass spectrometer (LC-MS)/MS method. RESULTS: There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study. The amount of MTB was the highest among the four components measured in the crude drugs. However, the amounts of MTB in all danshen preparations were much lower than those in crude drugs. The 2 lipophilic components, isotanshinone II A and cryptotanshinone, were very low or not detectable in both injection and oral preparations. CONCLUSION: MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources. In view of the variation in the amounts of MTB and other components, improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions.
Persistent Identifierhttp://hdl.handle.net/10722/80320
ISSN
2015 Impact Factor: 3.166
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorYu, Cen_HK
dc.contributor.authorJia, JYen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorSiow, YLen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorZhu, DYen_HK
dc.date.accessioned2010-09-06T08:05:00Z-
dc.date.available2010-09-06T08:05:00Z-
dc.date.issued2002en_HK
dc.identifier.citationActa Pharmacologica Sinica, 2002, v. 23 n. 12, p. 1163-1168en_HK
dc.identifier.issn1671-4083en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80320-
dc.description.abstractAIM: To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations. METHODS: Commercially available danshen crude drugs from different sources, as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected. The composition of these danshen samples was analyzed using HPLC. Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone II A, and cryptotanshinone were determined. In some of these samples, the content of MTB was further confirmed by liquid chromatography- tandem mass spectrometer (LC-MS)/MS method. RESULTS: There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study. The amount of MTB was the highest among the four components measured in the crude drugs. However, the amounts of MTB in all danshen preparations were much lower than those in crude drugs. The 2 lipophilic components, isotanshinone II A and cryptotanshinone, were very low or not detectable in both injection and oral preparations. CONCLUSION: MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources. In view of the variation in the amounts of MTB and other components, improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.htmlen_HK
dc.relation.ispartofActa Pharmacologica Sinicaen_HK
dc.subjectHigh pressure liquid chromatographyen_HK
dc.subjectMagnesium tanshinoate B (MTB)en_HK
dc.subjectSalvia miltiorrhizaen_HK
dc.titleContents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1671-4083&volume=23&issue=12&spage=1163&epage=1168&date=2002&atitle=Contents+of+four+active+components+in+different+commercial+crude+drugs+and+preparations+of+Danshen+(Salvia+miltiorrhiza)en_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid12466055-
dc.identifier.scopuseid_2-s2.0-0036902502en_HK
dc.identifier.hkuros76645en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036902502&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1163en_HK
dc.identifier.epage1168en_HK
dc.identifier.isiWOS:000179779100016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, H=36077401700en_HK
dc.identifier.scopusauthoridYu, C=11840158500en_HK
dc.identifier.scopusauthoridJia, JY=7202343588en_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridSiow, YL=7003336463en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.scopusauthoridZhu, DY=7403598969en_HK

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