File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Differential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells

TitleDifferential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells
Authors
KeywordsC-myc
Cancer cells
Cell proliferation
Cigarette smoking
Issue Date2003
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp
Citation
Cancer Investigation, 2003, v. 21 n. 2, p. 200-207 How to Cite?
AbstractSubstantial evidence show a higher incidence of gastric cancer in smokers than nonsmokers and that cigarette smoking is highly associated with colon cancer. The present study was designed to examine the effect of cigarette smoke extracts on gastric and colon cancer cell proliferation, which is important for tumor growth. Two different cell lines were used. One was gastric cancer cell line AGS, and the other was colon cancer cell line HT-29. It was found that cigarette smoke extracts stimulated cell proliferation and c-myc expression in AGS cells. Furthermore, this proliferative action was partially blocked by the c-myc antisense. However, the extracts significantly inhibited HT-29 cell proliferation and suppressed c-myc expression. In conclusion, cigarette smoke extracts stimulated AGS cell proliferation, while inhibiting HT-29 proliferation, which were partially mediated by a c-myc-related pathway. The former action may play a contributory role in the carcinogenic action of cigarette smoking in the stomach.
Persistent Identifierhttp://hdl.handle.net/10722/80319
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShin, VYen_HK
dc.contributor.authorWang, HYen_HK
dc.contributor.authorLiu, ESLen_HK
dc.contributor.authorKoo, MWLen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:05:00Z-
dc.date.available2010-09-06T08:05:00Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer Investigation, 2003, v. 21 n. 2, p. 200-207en_HK
dc.identifier.issn0735-7907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80319-
dc.description.abstractSubstantial evidence show a higher incidence of gastric cancer in smokers than nonsmokers and that cigarette smoking is highly associated with colon cancer. The present study was designed to examine the effect of cigarette smoke extracts on gastric and colon cancer cell proliferation, which is important for tumor growth. Two different cell lines were used. One was gastric cancer cell line AGS, and the other was colon cancer cell line HT-29. It was found that cigarette smoke extracts stimulated cell proliferation and c-myc expression in AGS cells. Furthermore, this proliferative action was partially blocked by the c-myc antisense. However, the extracts significantly inhibited HT-29 cell proliferation and suppressed c-myc expression. In conclusion, cigarette smoke extracts stimulated AGS cell proliferation, while inhibiting HT-29 proliferation, which were partially mediated by a c-myc-related pathway. The former action may play a contributory role in the carcinogenic action of cigarette smoking in the stomach.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.aspen_HK
dc.relation.ispartofCancer Investigationen_HK
dc.rightsCancer Investigation. Copyright © Informa Healthcare.en_HK
dc.subjectC-mycen_HK
dc.subjectCancer cellsen_HK
dc.subjectCell proliferationen_HK
dc.subjectCigarette smokingen_HK
dc.titleDifferential effects of cigarette smoke extracts on cell proliferation in gastric and colon cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0735-7907&volume=21 No 2&spage=200&epage=207&date=2003&atitle=Differential+effects+of+cigarette+smoke+extracts+on+cell+proliferation+in+gastric+and+colon+cellsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1081/CNV-120016416en_HK
dc.identifier.pmid12743985-
dc.identifier.scopuseid_2-s2.0-0038417035en_HK
dc.identifier.hkuros76720en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038417035&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue2en_HK
dc.identifier.spage200en_HK
dc.identifier.epage207en_HK
dc.identifier.isiWOS:000182665200005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShin, VY=7003491170en_HK
dc.identifier.scopusauthoridWang, HY=7501733456en_HK
dc.identifier.scopusauthoridLiu, ESL=7202240071en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats