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Article: Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG

TitleEnhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG
Authors
Lam, EKYTai, EKKKoo, MWLWong, HPSWu, WKKYu, LSo, WHLWoo, PCYCho, CH
KeywordsGastric lesion
Mucus layer
Prostaglandin E2
Transmucosal resistance
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2007, v. 80 n. 23, p. 2128-2136 How to Cite?
DOI: http://dx.doi.org/10.1016/j.lfs.2007.03.018
AbstractThe gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa from acute damage induced by intragastric administration of ethanol. Pre-treatment of rats with LGG at 109 cfu/ml twice daily for three consecutive days markedly reduced ethanol-induced mucosal lesion area by 45%. LGG pre-treatment also significantly increased the basal mucosal prostaglandin E2 (PGE2) level. In addition, LGG attenuated the suppressive actions of ethanol on mucus-secreting layer and transmucosal resistance and reduced cellular apoptosis in the gastric mucosa. It is suggested that the protective action of LGG on ethanol-induced gastric mucosal lesions is likely attributed to the up-regulation of PGE2, which could stimulate the mucus secretion and increase the transmucosal resistance in the gastric mucosa. All these would protect mucosal cells from apoptosis in the stomach. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80318
ISSN
0024-3205
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 1.257
ISI Accession Number ID
WOS:000247124000004
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLam, EKYen_HK
dc.contributor.authorTai, EKKen_HK
dc.contributor.authorKoo, MWLen_HK
dc.contributor.authorWong, HPSen_HK
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorYu, Len_HK
dc.contributor.authorSo, WHLen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:04:59Z-
dc.date.available2010-09-06T08:04:59Z-
dc.date.issued2007en_HK
dc.identifier.citationLife Sciences, 2007, v. 80 n. 23, p. 2128-2136en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80318-
dc.description.abstractThe gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa from acute damage induced by intragastric administration of ethanol. Pre-treatment of rats with LGG at 109 cfu/ml twice daily for three consecutive days markedly reduced ethanol-induced mucosal lesion area by 45%. LGG pre-treatment also significantly increased the basal mucosal prostaglandin E2 (PGE2) level. In addition, LGG attenuated the suppressive actions of ethanol on mucus-secreting layer and transmucosal resistance and reduced cellular apoptosis in the gastric mucosa. It is suggested that the protective action of LGG on ethanol-induced gastric mucosal lesions is likely attributed to the up-regulation of PGE2, which could stimulate the mucus secretion and increase the transmucosal resistance in the gastric mucosa. All these would protect mucosal cells from apoptosis in the stomach. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectGastric lesionen_HK
dc.subjectMucus layeren_HK
dc.subjectProstaglandin E2en_HK
dc.subjectTransmucosal resistanceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshDinoprostone - metabolismen_HK
dc.subject.meshEthanol - chemistry - pharmacologyen_HK
dc.subject.meshGastric Mucosa - metabolism - pathologyen_HK
dc.subject.meshLactobacillus rhamnosus - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMucin-6en_HK
dc.subject.meshMucins - biosynthesisen_HK
dc.subject.meshMucous Membrane - metabolismen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshUp-Regulationen_HK
dc.titleEnhancement of gastric mucosal integrity by Lactobacillus rhamnosus GGen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=80&spage=2128&epage=2136&date=2007&atitle=Enhancement+of+gastric+mucosal+integrity+by+Lactobacillus+rhamnosus+GGen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.emailWong, HPS: hpswong@hkusua.hku.hken_HK
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.identifier.authorityWong, HPS=rp00808en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2007.03.018en_HK
dc.identifier.pmid17499310-
dc.identifier.scopuseid_2-s2.0-34248674394en_HK
dc.identifier.hkuros157306en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248674394&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue23en_HK
dc.identifier.spage2128en_HK
dc.identifier.epage2136en_HK
dc.identifier.isiWOS:000247124000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, EKY=8644138600en_HK
dc.identifier.scopusauthoridTai, EKK=9842278900en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.scopusauthoridWong, HPS=8644138100en_HK
dc.identifier.scopusauthoridWu, WKK=18345422600en_HK
dc.identifier.scopusauthoridYu, L=16314581700en_HK
dc.identifier.scopusauthoridSo, WHL=7004974020en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK
dc.identifier.issnl0024-3205-

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