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Article: Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats

TitleInhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats
Authors
KeywordsApiaceae
Asiaticoside
Centella asiatica
Gastric ulcer
Inducible nitric oxide synthase
Issue Date2004
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html
Citation
Planta Medica, 2004, v. 70 n. 12, p. 1150-1154 How to Cite?
AbstractIn this study, the effects of Centella asiatica water extract (CE) and its active constituent, asiaticoside (AC), on the expression and activity of inducible nitric oxide synthase (iNOS) during gastric ulcer healing in rats were investigated. CE was prepared from Centella asiatica dry plant and the concentration of AC in CE was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of CE (0.10 g/kg and 0.25 g/kg) and AC (5 mg/kg and 10 mg/kg) were orally administered to rats with acetic acid-induced gastric ulcers. They were found to reduce the size of the ulcers at days 1, 3 and 7 after ulcer induction in a dose-dependent manner, with a concomitant attenuation of iNOS activity and protein expression at the ulcer tissues. The levels of nitrite and nitrate (NOX -), the stable end-products of nitric oxide (NO), in the gastric ulcer tissues were also decreased. N-[3-(aminomethyl)benzyl]acetamidine (1400W), a highly selective inhibitor of iNOS, was found to produce similar but more potent inhibition on iNOS activity at a dose of 0.1 mg/kg. These findings indicate that CE and AC have an anti-inflammatory property that is brought about by inhibition of NO synthesis and thus facilitates ulcer healing.
Persistent Identifierhttp://hdl.handle.net/10722/80297
ISSN
2015 Impact Factor: 1.99
2015 SCImago Journal Rankings: 0.702
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, SGen_HK
dc.contributor.authorChuen, LCen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:45Z-
dc.date.available2010-09-06T08:04:45Z-
dc.date.issued2004en_HK
dc.identifier.citationPlanta Medica, 2004, v. 70 n. 12, p. 1150-1154en_HK
dc.identifier.issn0032-0943en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80297-
dc.description.abstractIn this study, the effects of Centella asiatica water extract (CE) and its active constituent, asiaticoside (AC), on the expression and activity of inducible nitric oxide synthase (iNOS) during gastric ulcer healing in rats were investigated. CE was prepared from Centella asiatica dry plant and the concentration of AC in CE was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of CE (0.10 g/kg and 0.25 g/kg) and AC (5 mg/kg and 10 mg/kg) were orally administered to rats with acetic acid-induced gastric ulcers. They were found to reduce the size of the ulcers at days 1, 3 and 7 after ulcer induction in a dose-dependent manner, with a concomitant attenuation of iNOS activity and protein expression at the ulcer tissues. The levels of nitrite and nitrate (NOX -), the stable end-products of nitric oxide (NO), in the gastric ulcer tissues were also decreased. N-[3-(aminomethyl)benzyl]acetamidine (1400W), a highly selective inhibitor of iNOS, was found to produce similar but more potent inhibition on iNOS activity at a dose of 0.1 mg/kg. These findings indicate that CE and AC have an anti-inflammatory property that is brought about by inhibition of NO synthesis and thus facilitates ulcer healing.en_HK
dc.languageengen_HK
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.htmlen_HK
dc.relation.ispartofPlanta Medicaen_HK
dc.rightsPlanta Medica. Copyright © Georg Thieme Verlag.en_HK
dc.subjectApiaceaeen_HK
dc.subjectAsiaticosideen_HK
dc.subjectCentella asiaticaen_HK
dc.subjectGastric ulceren_HK
dc.subjectInducible nitric oxide synthaseen_HK
dc.titleInhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0032-0943&volume=70&spage=1150&epage=1154&date=2004&atitle=Inhibitory+Effects+of+Centella+asiatica+Water+Extract+and+Asiaticoside+on+Inducible+Nitric+Oxide+Synthase+During+Gastric+Ulcer+Healing+in+Ratsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1055/s-2004-835843en_HK
dc.identifier.pmid15643549-
dc.identifier.scopuseid_2-s2.0-11944255357en_HK
dc.identifier.hkuros97744en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-11944255357&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1150en_HK
dc.identifier.epage1154en_HK
dc.identifier.isiWOS:000226292900009-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridJin, SG=8415019300en_HK
dc.identifier.scopusauthoridChuen, LC=6507664932en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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