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Article: The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats

TitleThe healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats
Authors
KeywordsAngiogenesis
Asiaticoside
Cell proliferation
Centella water extract
Gastric ulcer
Myeloperoxidase
Rat
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2004, v. 74 n. 18, p. 2237-2249 How to Cite?
AbstractIn this study, the healing effects of Centella asiatica water extract (CE) and asiaticoside (AC), an active constituent of CE, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined. CE was prepared from Centella asiatica dry plant and the concentration of AC in CE was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of CE and AC were orally administered to rats with kissing ulcers. They were found to reduce the size of the ulcers at day 3 and 7 in a dose-dependent manner, with a concomitant attenuation of myeloperoxidase activity at the ulcer tissues. Epithelial cell proliferation and angiogenesis were on the other hand promoted. The expression of basic fibroblast growth factor, an important angiogenic factor, was also upregulated in the ulcer tissues in rats treated with CE or AC. These results further suggest the potential use of Centella asiatica and its active ingredient as anti-gastric ulcers drugs. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80296
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, CLen_HK
dc.contributor.authorGuo, JSen_HK
dc.contributor.authorLuk, Jen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:44Z-
dc.date.available2010-09-06T08:04:44Z-
dc.date.issued2004en_HK
dc.identifier.citationLife Sciences, 2004, v. 74 n. 18, p. 2237-2249en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80296-
dc.description.abstractIn this study, the healing effects of Centella asiatica water extract (CE) and asiaticoside (AC), an active constituent of CE, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined. CE was prepared from Centella asiatica dry plant and the concentration of AC in CE was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of CE and AC were orally administered to rats with kissing ulcers. They were found to reduce the size of the ulcers at day 3 and 7 in a dose-dependent manner, with a concomitant attenuation of myeloperoxidase activity at the ulcer tissues. Epithelial cell proliferation and angiogenesis were on the other hand promoted. The expression of basic fibroblast growth factor, an important angiogenic factor, was also upregulated in the ulcer tissues in rats treated with CE or AC. These results further suggest the potential use of Centella asiatica and its active ingredient as anti-gastric ulcers drugs. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectAngiogenesisen_HK
dc.subjectAsiaticosideen_HK
dc.subjectCell proliferationen_HK
dc.subjectCentella water extracten_HK
dc.subjectGastric ulceren_HK
dc.subjectMyeloperoxidaseen_HK
dc.subjectRaten_HK
dc.titleThe healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=74&spage=2237&epage=2249&date=2004&atitle=The+healing+effects+of+Centella+extract+and+asiaticoside+on+acetic+acid+induced+gastric+ulcers+in+ratsen_HK
dc.identifier.emailLuk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityLuk, J=rp00349en_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2003.09.055en_HK
dc.identifier.pmid14987949-
dc.identifier.scopuseid_2-s2.0-1342281647en_HK
dc.identifier.hkuros85975en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342281647&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue18en_HK
dc.identifier.spage2237en_HK
dc.identifier.epage2249en_HK
dc.identifier.isiWOS:000220014900003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, CL=7404797794en_HK
dc.identifier.scopusauthoridGuo, JS=7404488815en_HK
dc.identifier.scopusauthoridLuk, J=7006777791en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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